Carbamazepine decreased the Cmax and AUClast of Sildenafil by 36% in non–cannulated mice and 61% and 58% in cannulated mice respectively, as compared to control ...
To evaluate the mice pharmacokinetics model as a drug- drug interaction model by using Sildena l in the presence of Carbamazepine (CYP3A4 inducer) and ...
Missing: IJAR - | Show results with:IJAR -
Jul 18, 2024 · ORAL PHARMACOKINETICS OF SILDENAFIL IN THE PRESENCE OF CYP3A4-INDUCER AND -INHIBITOR USING CANNULATED AND NON- CANNULATED MALE SWISS ALBINO MICE.
Missing: IJAR - | Show results with:IJAR -
To determine the absolute bioavailability, dose proportionality and the effects of food on the pharmacokinetics of single oral doses of sildenafil citrate.
Missing: Cyp3a4 inducer Cannulated cannulated Swiss Albino IJAR - Indian Applied
Data for male and female animals have been combined for mouse and dog since there is no evidence of a gender difference in pharmacokinetics. Safety ratios have ...
Missing: Swiss IJAR - Indian Applied
Oct 27, 2023 · Our study investigated the pharmacokinetic parameters of the sildenafil citrate ODT in rats after oral administration and compared the absorption.
Missing: Presence Cyp3a4 inducer Cannulated cannulated Swiss Albino IJAR -
Sildenafil citrate, a widely-used oral therapy for erectile dysfunction, is a cytochrome P3A4 (CYP3A4) enzyme substrate. Studies have reported that this ...
Missing: Presence IJAR - Indian
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... male and female albino mice. Catalepsy was induced with haloperidol (1 mg/kg ... We found a significant difference for presence of the CYP2C19*2 polymorphism ...
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