WO2008058118A3 - Preparation of montelukast and its salts - Google Patents
Preparation of montelukast and its salts Download PDFInfo
- Publication number
- WO2008058118A3 WO2008058118A3 PCT/US2007/083756 US2007083756W WO2008058118A3 WO 2008058118 A3 WO2008058118 A3 WO 2008058118A3 US 2007083756 W US2007083756 W US 2007083756W WO 2008058118 A3 WO2008058118 A3 WO 2008058118A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- montelukast
- preparation
- salts
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Abstract
There is provided a process for the preparation of montelukast of the Formula (I).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07844907A EP2094665A4 (en) | 2006-11-06 | 2007-11-06 | Preparation of montelukast and its salts |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2042/CHE/2006 | 2006-11-06 | ||
IN2042CH2006 | 2006-11-06 | ||
IN142CH2007 | 2007-01-22 | ||
IN142/CHE/2007 | 2007-01-22 | ||
US89021507P | 2007-02-16 | 2007-02-16 | |
US60/890,215 | 2007-02-16 | ||
US91486207P | 2007-04-30 | 2007-04-30 | |
US60/914,862 | 2007-04-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008058118A2 WO2008058118A2 (en) | 2008-05-15 |
WO2008058118A3 true WO2008058118A3 (en) | 2008-07-10 |
Family
ID=39365306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/083756 WO2008058118A2 (en) | 2006-11-06 | 2007-11-06 | Preparation of montelukast and its salts |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2094665A4 (en) |
WO (1) | WO2008058118A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007005965A1 (en) | 2005-07-05 | 2007-01-11 | Teva Paharmaceutical Industries Ltd. | Purification of montelukast |
WO2008035379A2 (en) * | 2006-09-19 | 2008-03-27 | Aptuit Laurus Private Limited | Process for and intermediates of leukotriene antagonists |
WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
CN102702097A (en) * | 2012-05-16 | 2012-10-03 | 浙江大学 | Preparation method of montelukast sodium intermediate |
CN104109122B (en) * | 2013-04-16 | 2017-03-29 | 浙江奥翔药业股份有限公司 | For synthesizing midbody compound of montelukast and preparation method thereof |
CN103288695B (en) * | 2013-06-18 | 2016-01-13 | 成都迈斯克医药科技有限公司 | The preparation method of 1-thiopurine methyltransferase cyclopropaneacetic acid |
CN103554016B (en) * | 2013-08-23 | 2015-09-23 | 南通正达农化有限公司 | A kind of complete processing of non-hormone antiphlogiston intermediate |
CN103554017B (en) * | 2013-10-25 | 2014-12-17 | 河北序能生物技术有限公司 | Preparation method of montelukast chiral intermediate |
WO2015163978A1 (en) | 2014-04-25 | 2015-10-29 | R.P. Scherer Technologies, Llc | A stable montelukast solution |
CN104592110A (en) * | 2015-01-26 | 2015-05-06 | 中山奕安泰医药科技有限公司 | Synthesis process of 2-[[3-(S)-[3-[2-(7-chloro-2-quinolyl) ethenyl] phenyl]-3-hydroxypropyl] methyl benzoate |
CN109020830A (en) * | 2018-08-29 | 2018-12-18 | 广州康瑞泰药业有限公司 | A kind of methylol cyclopropyl acetonitrile derivative and its methods for making and using same |
CN114702416A (en) * | 2022-03-30 | 2022-07-05 | 法姆瑞斯医药科技(北京)有限公司 | Method for efficiently preparing montelukast sodium side chain intermediate |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565473A (en) * | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5614632A (en) * | 1993-12-28 | 1997-03-25 | Merck & Co., Inc. | Process for the preparation of leukotriene anatgonists |
US5869673A (en) * | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
US20010007040A1 (en) * | 1999-12-24 | 2001-07-05 | Andreas Harthun | Process for the preparation of 1,1-cyclopropanedicarboxylic diesters |
US20050234241A1 (en) * | 2004-04-15 | 2005-10-20 | Venkataraman Sundaram | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006021974A1 (en) * | 2004-08-23 | 2006-03-02 | Morepen Laboratories Limited | A process for synthesizing diol (viii)-an intermediate of montelukast sodium |
-
2007
- 2007-11-06 WO PCT/US2007/083756 patent/WO2008058118A2/en active Application Filing
- 2007-11-06 EP EP07844907A patent/EP2094665A4/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565473A (en) * | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5614632A (en) * | 1993-12-28 | 1997-03-25 | Merck & Co., Inc. | Process for the preparation of leukotriene anatgonists |
US5869673A (en) * | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
US20010007040A1 (en) * | 1999-12-24 | 2001-07-05 | Andreas Harthun | Process for the preparation of 1,1-cyclopropanedicarboxylic diesters |
US20050234241A1 (en) * | 2004-04-15 | 2005-10-20 | Venkataraman Sundaram | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts |
Non-Patent Citations (3)
Title |
---|
KUNDU ET AL.: "5-(Acetylthynyl)uracils, 5-(Acylethynyl)-2'-deoxyuridines and 5-(Acylethynyl)-1-(2-hydroxyethoxy)methyluracils. Their synthesis, antiviral and cytotoxic activities", EUR. J. MED. CHEM., vol. 34, 1999, pages 389 - 398, XP004180346 * |
SASSIAN ET AL.: "Solvation Effects in the Grignard Reacion with Carbonyl Compounds", HELVETICA CHIMICA ACTA, vol. 86, 2003, pages 82 - 90, XP008109226 * |
See also references of EP2094665A4 * |
Also Published As
Publication number | Publication date |
---|---|
EP2094665A4 (en) | 2010-11-24 |
EP2094665A2 (en) | 2009-09-02 |
WO2008058118A2 (en) | 2008-05-15 |
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