WO2007146900A3 - Antihypertensive therapy method - Google Patents

Antihypertensive therapy method Download PDF

Info

Publication number
WO2007146900A3
WO2007146900A3 PCT/US2007/070933 US2007070933W WO2007146900A3 WO 2007146900 A3 WO2007146900 A3 WO 2007146900A3 US 2007070933 W US2007070933 W US 2007070933W WO 2007146900 A3 WO2007146900 A3 WO 2007146900A3
Authority
WO
WIPO (PCT)
Prior art keywords
antihypertensive
diuretic
compound
formula
invention comprises
Prior art date
Application number
PCT/US2007/070933
Other languages
French (fr)
Other versions
WO2007146900A2 (en
Inventor
Richard J Gorczynski
Original Assignee
Gilead Colorado Inc
Richard J Gorczynski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Colorado Inc, Richard J Gorczynski filed Critical Gilead Colorado Inc
Priority to CA002655144A priority Critical patent/CA2655144A1/en
Priority to EP07798406A priority patent/EP2029137A2/en
Publication of WO2007146900A2 publication Critical patent/WO2007146900A2/en
Publication of WO2007146900A3 publication Critical patent/WO2007146900A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Methods and therapeutic combinations are provided for lowering blood pressure in a subject exhibiting resistance to a baseline antihypertensive therapy with one or more drugs, or a subject having diabetes and/or chronic kidney disease. A method of the invention comprises administering, in some embodiments adjunctively with a modified baseline therapy, a compound of formula (I) as defined herein. A therapeutic combination of the invention comprises a compound of formula (I); at least one diuretic; and at least one antihypertensive drug selected from ACE inhibitors, angiotensin II receptor blockers, beta-adrenergic receptor blockers and calcium channel blockers; wherein the at least one diuretic and/or the at least one antihypertensive drug are present at substantially less than a full dose.
PCT/US2007/070933 2006-06-15 2007-06-12 Antihypertensive therapy method WO2007146900A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002655144A CA2655144A1 (en) 2006-06-15 2007-06-12 Antihypertensive therapy method
EP07798406A EP2029137A2 (en) 2006-06-15 2007-06-12 Antihypertensive therapy method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81396606P 2006-06-15 2006-06-15
US60/813,966 2006-06-15

Publications (2)

Publication Number Publication Date
WO2007146900A2 WO2007146900A2 (en) 2007-12-21
WO2007146900A3 true WO2007146900A3 (en) 2008-02-28

Family

ID=38617518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/070933 WO2007146900A2 (en) 2006-06-15 2007-06-12 Antihypertensive therapy method

Country Status (4)

Country Link
US (1) US20070293552A1 (en)
EP (1) EP2029137A2 (en)
CA (1) CA2655144A1 (en)
WO (1) WO2007146900A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090090384A (en) * 2006-12-15 2009-08-25 노파르티스 아게 Renin inhibitors for the prevention and treatmemt of hypertension in obese patients
US9572856B2 (en) 2009-12-16 2017-02-21 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
WO2013049697A1 (en) * 2011-09-29 2013-04-04 Mayo Foundation For Medical Education And Research Aromatic-cationic peptides and methods for using same
CN106061493A (en) 2013-12-18 2016-10-26 乔治华盛顿大学国会特许非营利公司 Angiotensin ii alone or in combination for the treatment of hypotension
TW201733610A (en) * 2016-01-07 2017-10-01 拉荷亞製藥公司 Methods for administering angiotensin II
US10369156B2 (en) * 2016-11-15 2019-08-06 The George Institute for Global Health Compositions for the treatment of hypertension
CN110545819A (en) 2017-01-25 2019-12-06 乔治全球健康研究院 Composition for treating hypertension
US11174247B2 (en) 2017-02-27 2021-11-16 Idorsia Pharmaceuticals Ltd Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases
AU2019309329A1 (en) * 2018-07-26 2021-03-11 The George Institute for Global Health Compositions for the treatment of hypertension
RU2700563C1 (en) * 2018-09-14 2019-09-17 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Method of correcting endothelial dysfunction with trimetazidine in an adma-like model of preeclampsia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186083A1 (en) * 2003-03-18 2004-09-23 Pharmacia Corporation Combination of an aldosterone receptor antagonist and an endothelin receptor antagonist and/or endothelin converting enzyme inhibitor
EP1533311A1 (en) * 1999-12-31 2005-05-25 Encysive Pharmaceuticals Inc. Sulfonamides and derivatives thereof that modulate the activity of endothelin
WO2006026395A1 (en) * 2004-08-26 2006-03-09 Encysive Pharmaceuticals Endothelin a receptor (eta) antagonists in combination with phosphodiesterase 5 inhibitors (pde5) and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1533311A1 (en) * 1999-12-31 2005-05-25 Encysive Pharmaceuticals Inc. Sulfonamides and derivatives thereof that modulate the activity of endothelin
US20040186083A1 (en) * 2003-03-18 2004-09-23 Pharmacia Corporation Combination of an aldosterone receptor antagonist and an endothelin receptor antagonist and/or endothelin converting enzyme inhibitor
WO2006026395A1 (en) * 2004-08-26 2006-03-09 Encysive Pharmaceuticals Endothelin a receptor (eta) antagonists in combination with phosphodiesterase 5 inhibitors (pde5) and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Encysive Pharmaceuticals Initiates Dose Ranging Study of TBC3711", 9 January 2006 (2006-01-09), XP002457354, Retrieved from the Internet <URL://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/01-09-2006/0004244924&EDATE=> [retrieved on 20071031] *

Also Published As

Publication number Publication date
WO2007146900A2 (en) 2007-12-21
CA2655144A1 (en) 2007-12-21
EP2029137A2 (en) 2009-03-04
US20070293552A1 (en) 2007-12-20

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