WO1992014438A3 - Prostacycline and carbacycline derivatives as agents for treating feverish complaints - Google Patents

Prostacycline and carbacycline derivatives as agents for treating feverish complaints Download PDF

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Publication number
WO1992014438A3
WO1992014438A3 PCT/DE1992/000100 DE9200100W WO9214438A3 WO 1992014438 A3 WO1992014438 A3 WO 1992014438A3 DE 9200100 W DE9200100 W DE 9200100W WO 9214438 A3 WO9214438 A3 WO 9214438A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostacycline
complaints
treating
feverish
agents
Prior art date
Application number
PCT/DE1992/000100
Other languages
German (de)
French (fr)
Other versions
WO1992014438A2 (en
Inventor
Eveline Blitstein-Willinger
Karl-Heinz Thierauch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to AU12433/92A priority Critical patent/AU660449B2/en
Priority to JP4504121A priority patent/JPH06507381A/en
Publication of WO1992014438A2 publication Critical patent/WO1992014438A2/en
Publication of WO1992014438A3 publication Critical patent/WO1992014438A3/en
Priority to KR1019930702386A priority patent/KR930702990A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

The present invention relates to the use of prostacycline and carbacycline derivatives for the production of an agent for treating complaints which begin with a fever or disseminated intravascular coagulopathy and may be accompanied by cerebral complications.
PCT/DE1992/000100 1991-02-12 1992-02-11 Prostacycline and carbacycline derivatives as agents for treating feverish complaints WO1992014438A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU12433/92A AU660449B2 (en) 1991-02-12 1992-02-11 Prostacycline and carbacycline derivatives as agents for treating feverish complaints
JP4504121A JPH06507381A (en) 1991-02-12 1992-02-11 Prostacyclin and carbacyclin derivatives as medicines for the treatment of febrile diseases
KR1019930702386A KR930702990A (en) 1991-02-12 1993-08-11 Prostacyclin- and carbacycline derivatives for the treatment of fibrotic diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4104607.2 1991-02-12
DE4104607A DE4104607A1 (en) 1991-02-12 1991-02-12 PROSTACYCLIN AND CARBACYCLINE DERIVATIVES AS A MEDIUM FOR TREATING FEVERED DISEASES

Publications (2)

Publication Number Publication Date
WO1992014438A2 WO1992014438A2 (en) 1992-09-03
WO1992014438A3 true WO1992014438A3 (en) 1993-01-07

Family

ID=6425075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1992/000100 WO1992014438A2 (en) 1991-02-12 1992-02-11 Prostacycline and carbacycline derivatives as agents for treating feverish complaints

Country Status (7)

Country Link
EP (1) EP0571462A1 (en)
JP (1) JPH06507381A (en)
KR (1) KR930702990A (en)
AU (1) AU660449B2 (en)
CA (1) CA2104024A1 (en)
DE (1) DE4104607A1 (en)
WO (1) WO1992014438A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3230246B2 (en) * 1991-04-11 2001-11-19 東レ株式会社 Malignant tumor metastasis inhibitor
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
DE4124695C2 (en) * 1991-07-22 1994-12-22 Blitstein Willinger Eveline Dr Use of carbacyclin derivatives for the treatment of psoriasis vulgaris
DE4124693A1 (en) * 1991-07-22 1993-01-28 Schering Ag Use of carbocycline derivs. - esp. iloprost, cicaprost, eptaloprost, beraprost or ciprostene, for treatment of vitiligo
DE4226615C1 (en) * 1992-08-07 1994-05-19 Schering Ag Use of prostane derivatives for the treatment of chronic polyarthritis
DE19530884C2 (en) * 1995-08-11 1997-07-31 Schering Ag Use of prostane derivatives and their combination with antibiotics for the treatment of bacterial meningitis
CN1224354A (en) * 1997-02-27 1999-07-28 东丽株式会社 Drugs for ameliorating pulmonary circulation
EP0947195A4 (en) * 1997-03-14 1999-12-01 Toray Industries Protective agents for cells constituting nervous system
JPH11228417A (en) * 1998-02-06 1999-08-24 Teijin Ltd Neuropathy remedy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0011591A1 (en) * 1978-10-19 1980-05-28 Schering Aktiengesellschaft Prostane derivatives, their production and pharmaceutical compositions containing them
EP0084856A1 (en) * 1982-01-20 1983-08-03 Toray Industries, Inc. 5,6,7-Trinor-4, 8-inter-m-phenylene prostaglandin I2 derivatives
EP0099538A1 (en) * 1982-07-13 1984-02-01 Schering Aktiengesellschaft Carbacyclines, process for their preparation and their use as medicines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256883A (en) * 1979-03-14 1981-03-17 Research Corporation Pyridoza prostacyclin analogues and N-oxides thereof
DE3740838A1 (en) * 1987-11-27 1989-06-08 Schering Ag CYCLODEXTRINCLATHRATE OF 5-CYANO-PROSTACYCLINE DERIVATIVES AND THEIR USE AS MEDICINAL PRODUCTS
DE68918726T2 (en) * 1988-02-23 1995-03-02 Teijin Ltd Antidiabetic agents containing isocarbacyclin derivatives.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0011591A1 (en) * 1978-10-19 1980-05-28 Schering Aktiengesellschaft Prostane derivatives, their production and pharmaceutical compositions containing them
EP0084856A1 (en) * 1982-01-20 1983-08-03 Toray Industries, Inc. 5,6,7-Trinor-4, 8-inter-m-phenylene prostaglandin I2 derivatives
EP0099538A1 (en) * 1982-07-13 1984-02-01 Schering Aktiengesellschaft Carbacyclines, process for their preparation and their use as medicines

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemical Pharmacology, Band 41, Nr. 8, 1991, Pergamon Press plc, (GB), M. KAINOH et al.: "Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level", Seiten 1135-1140, siehe Zusammenfassung; Seite 1137, Zeile 39 - Seite 1140, Zeile 4 *
Blood, Band 76, Nr. 10, Suppl. 1, 15. November 1990, D.J. CRUTCHLEY et al.: "The stable prostacyclin analog, iloprost, is a potent inhibitor of human monocyte procoagulant activity", Seite 503a, siehe das ganze Dokument *
Blood, Band 78, Nr. 2, 15. Juli 1991, D.J. CRUTCHLEY et al.: "The stable prostacyclin analog, iloprost, and prostaglandin E, inhibit monocyte procoagulant activity in vitro", Seiten 382-386, siehe das ganze Dokument *
Chimical Intensive Care, Band 3, Nr. 2 (Suppl.), 1992, A. JÖRRES et al.: "Specific downregulation of TNFalpha in endotoxin-stimulated mononuclear leukocytes by the prostacyclin analogue iloprost", Seite 21, siehe das ganze Dokument *
Chimical Intensive Care, Band 3, Nr. 2 (Suppl.), 1992, U. HÄHNLE et al.: "Protective effect of iloprost, a prostacyclin analogue, in experimental endotoxic shock", Seite 8, siehe das ganze Dokument *
Infection and Immunity, Band 59, Nr. 10, Oktober 1991, American Society for Microbiology, K. SLIWA et al.: "Prevention of murine cerebral malaria by a stable prostacyclin analog", Seiten 3846-3848, siehe das ganze Dokument *

Also Published As

Publication number Publication date
CA2104024A1 (en) 1992-08-13
AU1243392A (en) 1992-09-15
EP0571462A1 (en) 1993-12-01
AU660449B2 (en) 1995-06-29
KR930702990A (en) 1993-11-29
WO1992014438A2 (en) 1992-09-03
DE4104607A1 (en) 1992-08-13
JPH06507381A (en) 1994-08-25

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