DE69928610D1 - Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen - Google Patents

Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen

Info

Publication number
DE69928610D1
DE69928610D1 DE69928610T DE69928610T DE69928610D1 DE 69928610 D1 DE69928610 D1 DE 69928610D1 DE 69928610 T DE69928610 T DE 69928610T DE 69928610 T DE69928610 T DE 69928610T DE 69928610 D1 DE69928610 D1 DE 69928610D1
Authority
DE
Germany
Prior art keywords
preparation
pyridines
carbamoyl
carbamoylation
concerned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928610T
Other languages
English (en)
Other versions
DE69928610T2 (de
Inventor
Uwe Klinkhammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69928610D1 publication Critical patent/DE69928610D1/de
Application granted granted Critical
Publication of DE69928610T2 publication Critical patent/DE69928610T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
DE69928610T 1998-08-10 1999-07-30 Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen Expired - Lifetime DE69928610T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98114978 1998-08-10
EP98114978 1998-08-10

Publications (2)

Publication Number Publication Date
DE69928610D1 true DE69928610D1 (de) 2006-01-05
DE69928610T2 DE69928610T2 (de) 2006-08-10

Family

ID=8232437

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928610T Expired - Lifetime DE69928610T2 (de) 1998-08-10 1999-07-30 Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen

Country Status (10)

Country Link
US (1) US6103902A (de)
EP (1) EP0979822B1 (de)
JP (1) JP3344972B2 (de)
KR (1) KR100362081B1 (de)
CN (1) CN1117746C (de)
AT (1) ATE311382T1 (de)
CA (1) CA2279796C (de)
DE (1) DE69928610T2 (de)
DK (1) DK0979822T3 (de)
ES (1) ES2252894T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
CN105669542A (zh) * 2016-03-08 2016-06-15 南京师范大学 一种直接催化氧化法合成吡啶伯酰胺化合物的方法
WO2022096549A1 (en) 2020-11-05 2022-05-12 Idorsia Pharmaceuticals Ltd A stable crystalline hydrate of clazosentan disodium salt
WO2023111299A1 (en) 2021-12-17 2023-06-22 Idorsia Pharmaceuticals Ltd Clazosentan disodium salt, its preparation and pharmaceutical compositions comprising the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW313568B (de) * 1994-12-20 1997-08-21 Hoffmann La Roche

Also Published As

Publication number Publication date
CN1117746C (zh) 2003-08-13
US6103902A (en) 2000-08-15
KR100362081B1 (ko) 2002-11-23
CA2279796A1 (en) 2000-02-10
CN1245803A (zh) 2000-03-01
JP3344972B2 (ja) 2002-11-18
CA2279796C (en) 2003-09-30
ATE311382T1 (de) 2005-12-15
EP0979822B1 (de) 2005-11-30
JP2000063377A (ja) 2000-02-29
DE69928610T2 (de) 2006-08-10
ES2252894T3 (es) 2006-05-16
DK0979822T3 (da) 2006-03-27
KR20000017194A (ko) 2000-03-25
EP0979822A1 (de) 2000-02-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition