DE69519788D1 - Verfahren zur Herstellung eines Tetrazolderivates in zwei kristallinen Formen und eine neue Kristallform dieses Derivates - Google Patents

Verfahren zur Herstellung eines Tetrazolderivates in zwei kristallinen Formen und eine neue Kristallform dieses Derivates

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Publication number
DE69519788D1
DE69519788D1 DE69519788T DE69519788T DE69519788D1 DE 69519788 D1 DE69519788 D1 DE 69519788D1 DE 69519788 T DE69519788 T DE 69519788T DE 69519788 T DE69519788 T DE 69519788T DE 69519788 D1 DE69519788 D1 DE 69519788D1
Authority
DE
Germany
Prior art keywords
derivative
water
ray diffraction
diffraction pattern
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69519788T
Other languages
English (en)
Other versions
DE69519788T2 (de
Inventor
Antoine Caron
Dominique Chantreux
Colette Bouloumie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of DE69519788D1 publication Critical patent/DE69519788D1/de
Publication of DE69519788T2 publication Critical patent/DE69519788T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
DE69519788T 1994-10-19 1995-10-18 Verfahren zur Herstellung eines Tetrazolderivates in zwei kristallinen Formen und eine neue Kristallform dieses Derivates Expired - Lifetime DE69519788T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9412459A FR2725987B1 (fr) 1994-10-19 1994-10-19 Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive

Publications (2)

Publication Number Publication Date
DE69519788D1 true DE69519788D1 (de) 2001-02-08
DE69519788T2 DE69519788T2 (de) 2001-08-30

Family

ID=9467986

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69519788T Expired - Lifetime DE69519788T2 (de) 1994-10-19 1995-10-18 Verfahren zur Herstellung eines Tetrazolderivates in zwei kristallinen Formen und eine neue Kristallform dieses Derivates

Country Status (27)

Country Link
US (1) US5629331A (de)
EP (1) EP0708103B1 (de)
JP (1) JP3366786B2 (de)
KR (1) KR100251222B1 (de)
CN (1) CN1061656C (de)
AT (1) ATE198478T1 (de)
AU (1) AU698041B2 (de)
CA (1) CA2160725C (de)
CY (1) CY2277B1 (de)
CZ (2) CZ288629B6 (de)
DE (1) DE69519788T2 (de)
DK (1) DK0708103T3 (de)
ES (1) ES2155115T3 (de)
FI (1) FI114156B (de)
FR (1) FR2725987B1 (de)
GR (1) GR3035503T3 (de)
HK (1) HK1005135A1 (de)
HU (1) HU226461B1 (de)
IL (1) IL115688A (de)
NO (1) NO307516B1 (de)
NZ (1) NZ280293A (de)
PL (1) PL184193B1 (de)
PT (1) PT708103E (de)
RU (1) RU2144536C1 (de)
SI (1) SI0708103T1 (de)
TW (1) TW357147B (de)
ZA (1) ZA958850B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994348A (en) * 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
TW442301B (en) * 1995-06-07 2001-06-23 Sanofi Synthelabo Pharmaceutical compositions containing irbesartan
FR2780403B3 (fr) * 1998-06-24 2000-07-21 Sanofi Sa Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
CA2336714A1 (en) 1998-07-06 2000-01-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2003050110A1 (en) * 2001-12-10 2003-06-19 Dr. Reddy's Laboratories Ltd. Amorphous form of 2-n-butyl-3-( (2-(1h-tetrazol-5-yl) (1,1'-biphenyl)-4-yl) methyl) -1,3-diazaspiro (4,4') non-1-en-4-one
ATE340793T1 (de) * 2002-07-16 2006-10-15 Teva Pharma Neue synthese von irbesartan
SI1509517T1 (sl) * 2003-01-16 2008-10-31 Teva Pharma Nova sinteza irbesartana
WO2004072064A1 (en) * 2003-02-05 2004-08-26 Teva Pharmaceutical Industries Ltd. Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol[4,4]-non-ene-4-one
WO2004089938A1 (en) * 2003-04-07 2004-10-21 Hetero Drugs Limited A novel crystalline form of irbesartan
WO2005051943A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Processes for the preparation of highly pure irbesartan
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
WO2006001026A1 (en) * 2004-06-23 2006-01-05 Hetero Drugs Limited Irbesartan polymorphs
SI21849A (sl) * 2004-07-29 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Priprava hidrokloridnih soli tetrazolskega derivata
TWI346108B (en) * 2004-08-23 2011-08-01 Bristol Myers Squibb Co A method for preparing irbesartan and intermediates thereof
GB2419592A (en) * 2004-10-26 2006-05-03 Cipla Ltd Process for the preparation of irbesartan hydrochloride
ES2454197T3 (es) * 2004-11-11 2014-04-09 Lek Pharmaceuticals D.D. Formas polimórficas de Irbesartán
ES2259909B1 (es) * 2005-02-28 2007-06-16 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de su intermedio de sintesis.
EP1951714A1 (de) 2005-07-27 2008-08-06 Jubilant Organosys Limited Verfahren zur herstellung von 2-(n-butyl)-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-on
ES2340701T3 (es) 2006-01-09 2010-06-08 Krka, D.D., Novo Mesto Composicion farmaceutica solida que comprende irbesartan.
WO2008041957A1 (en) * 2006-10-03 2008-04-10 Ulkar Kimya Sanayi Ve Ticaret As Method for producing pure crystalline form of 2-n-butyl-3-((2-(1h-tetrazole-5-yl) (1,1'-biphenyl)-4-methyl)-1,3-diazapspiro (4,4') non -1- en-4-one
EP1918288A1 (de) 2006-11-02 2008-05-07 Cadila Pharmaceuticals Limited Neues und verbessertes Verfahren für die Zubereitung von Irbesartan, einem Angiotensin-II Rezeptorantagonisten für die Behandlung von Bluthochdruck
DE602007007968D1 (de) * 2007-11-28 2010-09-02 Lesvi Laboratorios Sl Pharmazeutische Formulierungen mit Irbesartan
US20100234614A1 (en) * 2007-12-07 2010-09-16 Hetero Drugs Limited Process for pure irbesartan
KR101009383B1 (ko) * 2008-04-30 2011-01-19 켐젠주식회사 고순도의2-부틸-3-[[2'-(1에이취-테트라졸-5-일)[1,1'-비페닐]-4-일]메틸]-1,3-디아자스피로[4.4]논-1-엔-4-온 화합물의제조방법
US8609859B2 (en) * 2009-04-08 2013-12-17 Ctx Life Sciences Pvt. Ltd. One pot process for preparing 2-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro [4, 4] non-1-en-4-one (irbesartan)
AR078107A1 (es) * 2009-08-31 2011-10-12 Sanofi Aventis Uso de irbesartan para la preparacion de un medicamento para la prevencion de la hospitalizacion por insuficiencia cardiaca
US8080670B2 (en) 2010-05-04 2011-12-20 Divi's Laboratories, Ltd. Process for the preparation of irbesartan
FR2977253B1 (fr) 2011-06-30 2013-08-09 Centre Nat Rech Scient Reactif organostannique alcoxyle supporte, preparation et utilisation pour la synthese de tetrazoles en phase heterogene
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US11655220B2 (en) 2020-10-22 2023-05-23 Hetero Labs Limited Process for the preparation of angiotensin II receptor blockers
WO2023052309A1 (en) 2021-10-01 2023-04-06 Sanofi Process for preparing sartan active compounds having a tetrazole ring

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
JP2697919B2 (ja) * 1989-09-29 1998-01-19 キヤノン株式会社 信号内挿回路及び該回路を備えた変位測定装置
IL99372A0 (en) * 1990-09-10 1992-08-18 Ciba Geigy Ag Azacyclic compounds

Also Published As

Publication number Publication date
TW357147B (en) 1999-05-01
GR3035503T3 (en) 2001-06-29
AU698041B2 (en) 1998-10-22
CZ288624B6 (cs) 2001-08-15
CZ288629B6 (cs) 2001-08-15
FR2725987B1 (fr) 1997-01-10
NO954154D0 (no) 1995-10-18
FI954992A0 (fi) 1995-10-19
DE69519788T2 (de) 2001-08-30
ES2155115T3 (es) 2001-05-01
HU9503016D0 (en) 1995-12-28
JPH08208642A (ja) 1996-08-13
DK0708103T3 (da) 2001-04-23
NO307516B1 (no) 2000-04-17
KR100251222B1 (ko) 2000-05-01
CN1128261A (zh) 1996-08-07
HK1005135A1 (en) 1998-12-24
SI0708103T1 (en) 2001-04-30
NO954154L (no) 1996-04-22
NZ280293A (en) 1997-10-24
CA2160725A1 (en) 1996-04-20
AU3433595A (en) 1996-05-02
CZ271095A3 (en) 1996-05-15
CA2160725C (en) 2001-12-18
FR2725987A1 (fr) 1996-04-26
PT708103E (pt) 2001-06-29
CY2277B1 (en) 2003-07-04
US5629331A (en) 1997-05-13
HU226461B1 (en) 2008-12-29
PL184193B1 (pl) 2002-09-30
EP0708103A1 (de) 1996-04-24
KR960014122A (ko) 1996-05-22
JP3366786B2 (ja) 2003-01-14
FI954992A (fi) 1996-04-20
IL115688A0 (en) 1996-01-19
ATE198478T1 (de) 2001-01-15
FI114156B (fi) 2004-08-31
CN1061656C (zh) 2001-02-07
IL115688A (en) 1999-09-22
RU2144536C1 (ru) 2000-01-20
ZA958850B (en) 1996-05-27
EP0708103B1 (de) 2001-01-03
PL311012A1 (en) 1996-04-29
HUT73179A (en) 1996-06-28

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