DE602004019049D1 - Stabile feste medizinische zusammensetzung für die orale verabreichung von ramosetron - Google Patents
Stabile feste medizinische zusammensetzung für die orale verabreichung von ramosetronInfo
- Publication number
- DE602004019049D1 DE602004019049D1 DE602004019049T DE602004019049T DE602004019049D1 DE 602004019049 D1 DE602004019049 D1 DE 602004019049D1 DE 602004019049 T DE602004019049 T DE 602004019049T DE 602004019049 T DE602004019049 T DE 602004019049T DE 602004019049 D1 DE602004019049 D1 DE 602004019049D1
- Authority
- DE
- Germany
- Prior art keywords
- ramosetron
- ester
- pharmaceutically acceptable
- acid
- oral administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NTHPAPBPFQJABD-LLVKDONJSA-N ramosetron Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)[C@H]1CC(NC=N2)=C2CC1 NTHPAPBPFQJABD-LLVKDONJSA-N 0.000 title abstract 5
- 229950001588 ramosetron Drugs 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- -1 aromatic carboxyl compound Chemical class 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003023500 | 2003-01-31 | ||
| PCT/JP2004/000896 WO2004066998A1 (ja) | 2003-01-31 | 2004-01-30 | 安定な経口用固形医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004019049D1 true DE602004019049D1 (de) | 2009-03-05 |
Family
ID=32820728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004019049T Expired - Lifetime DE602004019049D1 (de) | 2003-01-31 | 2004-01-30 | Stabile feste medizinische zusammensetzung für die orale verabreichung von ramosetron |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7794748B2 (de) |
| EP (1) | EP1588707B1 (de) |
| JP (1) | JP3689104B2 (de) |
| KR (1) | KR100633836B1 (de) |
| CN (1) | CN100379416C (de) |
| AT (1) | ATE420638T1 (de) |
| AU (1) | AU2004208617B2 (de) |
| BR (1) | BRPI0405221A (de) |
| CA (1) | CA2488422C (de) |
| DE (1) | DE602004019049D1 (de) |
| DK (1) | DK1588707T3 (de) |
| ES (1) | ES2319292T3 (de) |
| HK (1) | HK1084582A1 (de) |
| IL (1) | IL165371A (de) |
| MX (1) | MXPA04012462A (de) |
| NO (1) | NO20045153L (de) |
| NZ (1) | NZ537448A (de) |
| PL (1) | PL375181A1 (de) |
| PT (1) | PT1588707E (de) |
| RU (1) | RU2284819C2 (de) |
| WO (1) | WO2004066998A1 (de) |
| ZA (2) | ZA200409537B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| US7358270B2 (en) * | 2004-01-30 | 2008-04-15 | Astellas Pharma Inc. | Treating agent for irritable bowel syndrome |
| MX2009001429A (es) * | 2006-08-10 | 2009-02-17 | Takeda Pharmaceutical | Composicion farmaceutica. |
| CN101516367A (zh) * | 2006-09-15 | 2009-08-26 | 安斯泰来制药有限公司 | 对光稳定的雷莫司琼的固态医药组合物 |
| CN103601792B (zh) | 2007-06-04 | 2016-06-29 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (de) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
| CN102811770B (zh) * | 2010-04-09 | 2014-07-09 | 荷兰联合利华有限公司 | 口腔护理组合物 |
| WO2012083138A2 (en) | 2010-12-16 | 2012-06-21 | Board Of Regents, The University Of Texas System | Azole pharmaceutical formulations for parenteral administration and methods for preparing and using the same as treatment of diseases sensitive to azole compounds |
| ES2640572T3 (es) | 2011-04-28 | 2017-11-03 | Platform Brightworks Two, Ltd. | Formulaciones parenterales mejoradas de agentes farmacéuticos lipófilos y procedimientos de preparación y uso de las mismas |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| EP3513788B1 (de) * | 2015-03-19 | 2020-07-29 | Daiichi Sankyo Company, Limited | Feststoffpräparat mit farbstoff |
| WO2016148263A1 (ja) | 2015-03-19 | 2016-09-22 | 第一三共株式会社 | 抗酸化剤を含有する固形製剤 |
| CN106937946B (zh) * | 2016-01-05 | 2020-05-12 | 山东诚创医药技术开发有限公司 | 盐酸雷莫司琼泡腾片及其制备方法 |
| CN107224430A (zh) * | 2016-03-25 | 2017-10-03 | 江苏奥赛康药业股份有限公司 | 一种含盐酸雷莫司琼的药物组合物 |
| KR102349971B1 (ko) * | 2016-04-27 | 2022-01-12 | 주식회사 엘지생활건강 | 폴리다틴 또는 이의 약학적으로 허용 가능한 염의 광 안정화용 조성물 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB759081A (en) * | 1954-04-15 | 1956-10-10 | John Holroyd And Company Ltd | Improvements relating to machines for the production of coated tablets and the like |
| US4067974A (en) * | 1976-01-21 | 1978-01-10 | The Purdue Frederick Company | Stabilized solid form choline salicylate compositions |
| GB8629567D0 (en) | 1986-12-10 | 1987-01-21 | Boots Co Plc | Therapeutic agents |
| US5223508A (en) | 1988-12-27 | 1993-06-29 | Kirin Beer Kabushiki Kaisha | Pyridyl carboximidamide compounds useful in treating blood pressure |
| US5344927A (en) | 1989-02-02 | 1994-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same |
| US5107887A (en) | 1990-12-03 | 1992-04-28 | The Aro Corporation | High pressure fluid regulator |
| JPH0565226A (ja) * | 1991-09-10 | 1993-03-19 | Taisho Pharmaceut Co Ltd | アミノアルキルピリジルオキシ誘導体の安定化組成物 |
| EP0948965B1 (de) | 1997-07-11 | 2004-06-02 | Toray Industries, Inc. | Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten |
| GB9721139D0 (en) | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
| US6297244B1 (en) * | 1997-10-20 | 2001-10-02 | Dainippon Pharmaceutical Co., Ltd. | Stable drug composition |
| PT1205190E (pt) * | 1999-08-04 | 2006-09-29 | Astellas Pharma Inc | Composicoes medicinais estaveis para uso oral utilizando oxidos de ferro |
| AU6280900A (en) | 1999-08-09 | 2001-03-05 | Pharmacia & Upjohn S.P.A. | Formulations for parenteral use of estramustine phosphate and albumin |
| DE19941997A1 (de) * | 1999-09-02 | 2001-03-08 | Gunther Meinhardt Voss | Verfahren und Vorrichtung zur Herstellung einer Tablette o. dgl. |
| MXPA03000520A (es) | 2000-07-17 | 2003-10-06 | Yamanouchi Pharma Co Ltd | Composicion farmaceutica mejorada en absorbabilidad peroral.. |
| US6566369B2 (en) | 2000-07-26 | 2003-05-20 | Solvay Pharmaceuticals Gmbh | Medicament containing cilansetron for the treatment of non-obstipative male irritable bowel syndrome patients |
| JP4019374B2 (ja) * | 2001-07-27 | 2007-12-12 | アステラス製薬株式会社 | 口腔内速崩壊錠用徐放性微粒子含有組成物およびその製造法 |
| GB0119012D0 (en) * | 2001-08-03 | 2001-09-26 | Strakan Group Plc | Transdermal delivery of drugs |
| US20030143548A1 (en) | 2002-01-28 | 2003-07-31 | Camilleri Michael L. | Predicting patient responsiveness to serotonergic therapy |
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| US7358270B2 (en) | 2004-01-30 | 2008-04-15 | Astellas Pharma Inc. | Treating agent for irritable bowel syndrome |
-
2004
- 2004-01-01 ZA ZA200409537A patent/ZA200409537B/en unknown
- 2004-01-30 NZ NZ537448A patent/NZ537448A/en not_active IP Right Cessation
- 2004-01-30 ES ES04706797T patent/ES2319292T3/es not_active Expired - Lifetime
- 2004-01-30 PT PT04706797T patent/PT1588707E/pt unknown
- 2004-01-30 CA CA002488422A patent/CA2488422C/en not_active Expired - Fee Related
- 2004-01-30 RU RU2004136181/15A patent/RU2284819C2/ru not_active IP Right Cessation
- 2004-01-30 WO PCT/JP2004/000896 patent/WO2004066998A1/ja active Application Filing
- 2004-01-30 CN CNB2004800003517A patent/CN100379416C/zh not_active Expired - Fee Related
- 2004-01-30 BR BR0405221-8A patent/BRPI0405221A/pt not_active IP Right Cessation
- 2004-01-30 MX MXPA04012462A patent/MXPA04012462A/es active IP Right Grant
- 2004-01-30 AU AU2004208617A patent/AU2004208617B2/en not_active Ceased
- 2004-01-30 KR KR1020047020096A patent/KR100633836B1/ko active Protection Beyond IP Right Term
- 2004-01-30 AT AT04706797T patent/ATE420638T1/de active
- 2004-01-30 EP EP04706797A patent/EP1588707B1/de not_active Expired - Lifetime
- 2004-01-30 PL PL04375181A patent/PL375181A1/xx unknown
- 2004-01-30 DK DK04706797T patent/DK1588707T3/da active
- 2004-01-30 JP JP2004564051A patent/JP3689104B2/ja not_active Expired - Lifetime
- 2004-01-30 DE DE602004019049T patent/DE602004019049D1/de not_active Expired - Lifetime
- 2004-08-27 US US10/928,464 patent/US7794748B2/en not_active Expired - Fee Related
- 2004-11-24 IL IL165371A patent/IL165371A/en not_active IP Right Cessation
- 2004-11-25 NO NO20045153A patent/NO20045153L/no not_active Application Discontinuation
-
2005
- 2005-08-15 ZA ZA200506503A patent/ZA200506503B/xx unknown
-
2006
- 2006-04-24 HK HK06104829A patent/HK1084582A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2004136181A (ru) | 2005-08-10 |
| MXPA04012462A (es) | 2005-02-24 |
| US20050026981A1 (en) | 2005-02-03 |
| AU2004208617B2 (en) | 2007-09-13 |
| CN1723021A (zh) | 2006-01-18 |
| DK1588707T3 (da) | 2009-03-09 |
| EP1588707A4 (de) | 2006-03-15 |
| CA2488422A1 (en) | 2004-08-12 |
| IL165371A (en) | 2009-08-03 |
| RU2284819C2 (ru) | 2006-10-10 |
| NZ537448A (en) | 2008-06-30 |
| ATE420638T1 (de) | 2009-01-15 |
| JPWO2004066998A1 (ja) | 2006-05-18 |
| ES2319292T3 (es) | 2009-05-06 |
| NO20045153L (no) | 2005-02-04 |
| BRPI0405221A (pt) | 2005-03-15 |
| PL375181A1 (en) | 2005-11-28 |
| PT1588707E (pt) | 2009-03-27 |
| IL165371A0 (en) | 2006-01-15 |
| KR100633836B1 (ko) | 2006-10-13 |
| KR20050044772A (ko) | 2005-05-12 |
| ZA200506503B (en) | 2006-12-27 |
| US7794748B2 (en) | 2010-09-14 |
| AU2004208617A1 (en) | 2004-08-12 |
| AU2004208617A2 (en) | 2004-08-12 |
| WO2004066998A1 (ja) | 2004-08-12 |
| EP1588707B1 (de) | 2009-01-14 |
| CN100379416C (zh) | 2008-04-09 |
| CA2488422C (en) | 2008-08-19 |
| ZA200409537B (en) | 2006-10-25 |
| EP1588707A1 (de) | 2005-10-26 |
| HK1084582A1 (en) | 2006-08-04 |
| JP3689104B2 (ja) | 2005-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1084582A1 (en) | Stable solid medicinal composition for oral administration | |
| EE200300403A (et) | N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina | |
| BR0315580A (pt) | Derivados de metileno uréia | |
| BG106439A (en) | Pharmaceutical composition of improved solubility and oral absorptivity, containing benzamide derivative | |
| YU75903A (sh) | Tiohidantoini i njihovo korišćenje u lečenju dijabetisa | |
| DE60131088D1 (de) | Gelierende wässrige pharmazeutische zusammensetzungen | |
| EE200200245A (et) | Farmatseutiline kompositsioon, mis sisaldab tolterodiini ja selle kasutamine | |
| BRPI0418074B8 (pt) | derivado de amida, composição farmacêutica, inibidor da tirosina cinase bcr-abl e agentes terapêuticos | |
| DE68914438D1 (de) | N-(3,4-dimethoxycinnamoyl)-Anthranilsäure enthaltende Arzneimittelzusammensetzungen. | |
| PE20060771A1 (es) | Profarmaco de amida de gemcitabina y composiciones que lo contienen | |
| SE9901573D0 (sv) | New compounds | |
| DE60035429D1 (de) | Verwendung von sulfodehydroabietinsäure zur behandlung entzündlicher darmerkrankungen | |
| ES2391812T3 (es) | Composiciones estables de rosuvastatina | |
| NO20083183L (no) | Fast farmasoytisk sammensetning inneholdende irbesartan | |
| NO912414D0 (no) | Forbindelse med mavesyreinhiberende effekt og fremgangsmaate for dens fremstilling. | |
| BR0013283A (pt) | Agente farmacêutico que compreende um derivado de benzamida como ingrediente ativo | |
| SE9901572D0 (sv) | New compounds | |
| NO20015666D0 (no) | Umiddelbar frigivelses medisinske sammensetninger for oral anvendelse | |
| NO323556B1 (no) | Forbindelser, farmasoytiske preparater som omfatter forbindelsene, og anvendelse av forbindelsene ved fremstilling av antibakterielle medikamenter. | |
| MXPA05008711A (es) | Uso de r-10-hidroxi-10,11-dihidro-carbamazepina en dolor neuropatico. | |
| PT97164A (pt) | Processo para a estabilizacao de uma preparacao que contenham o composto 4-etil-2-hidroxi-imino-5-nitro-3-hexenamida e de composicoes farmaceuticas que o contenham | |
| HRP20090592T1 (hr) | Izoksazolni derivat za ublažavanje neuropatskih bolova | |
| TH45966A3 (th) | แอนตี้ฮิสตามีน ไซรัปที่เสถียร |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |