DE3367774D1 - 5,6,7-trinor-4, 8-inter-m-phenylene prostaglandin i2 derivatives - Google Patents
5,6,7-trinor-4, 8-inter-m-phenylene prostaglandin i2 derivativesInfo
- Publication number
- DE3367774D1 DE3367774D1 DE8383100449T DE3367774T DE3367774D1 DE 3367774 D1 DE3367774 D1 DE 3367774D1 DE 8383100449 T DE8383100449 T DE 8383100449T DE 3367774 T DE3367774 T DE 3367774T DE 3367774 D1 DE3367774 D1 DE 3367774D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- hydrogen
- trinor
- inter
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
- C07C29/124—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids of halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57006150A JPS58124778A (ja) | 1982-01-20 | 1982-01-20 | ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3367774D1 true DE3367774D1 (de) | 1987-01-08 |
Family
ID=11630492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8383100449T Expired DE3367774D1 (de) | 1982-01-20 | 1983-01-19 | 5,6,7-trinor-4, 8-inter-m-phenylene prostaglandin i2 derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4474802A (de) |
| EP (1) | EP0084856B2 (de) |
| JP (1) | JPS58124778A (de) |
| AT (1) | ATE23716T1 (de) |
| AU (1) | AU556348B2 (de) |
| CA (1) | CA1226280A (de) |
| DE (1) | DE3367774D1 (de) |
| ZA (1) | ZA83328B (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775692A (en) * | 1986-01-24 | 1988-10-04 | Toray Industries, Inc. | 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives |
| US4880939A (en) * | 1986-12-11 | 1989-11-14 | Toray Industries | 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives |
| EP0463162B1 (de) * | 1989-02-27 | 1994-05-11 | Toray Industries, Inc. | VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen |
| ES2060944T3 (es) * | 1989-03-14 | 1994-12-01 | Toray Industries | Derivados de 2,5,6,7-tetranor-4,8-inter-m-fenileno de pgi2 (prostaglandina i2). |
| JP2608135B2 (ja) * | 1989-03-31 | 1997-05-07 | 科研製薬株式会社 | 糖尿病性神経障害治療剤 |
| DE4104607A1 (de) * | 1991-02-12 | 1992-08-13 | Schering Ag | Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen |
| JP3230246B2 (ja) * | 1991-04-11 | 2001-11-19 | 東レ株式会社 | 悪性腫瘍転移抑制剤 |
| US5496850A (en) * | 1991-04-11 | 1996-03-05 | Toray Industries, Inc. | Antimetastasis agent of malignant tumors |
| US5233059A (en) * | 1991-07-25 | 1993-08-03 | Iowa State University Research Foundation, Inc. | Synthesis of benzoprostacyclins using palladium catalysis |
| US5169959A (en) * | 1991-09-23 | 1992-12-08 | Iowa State University Research Foundation, Inc. | Free radical-catalyzed synthesis of benzoprostacyclins |
| WO1993007876A1 (fr) * | 1991-10-25 | 1993-04-29 | Toray Industries, Inc. | Remede contre les maladies hepatiques |
| JP3102141B2 (ja) * | 1992-05-29 | 2000-10-23 | 東レ株式会社 | 養毛育毛剤 |
| ATE149838T1 (de) * | 1992-08-07 | 1997-03-15 | Schering Ag | Verwendung von prostanderivaten zur herstellung eines arzneimittels zur behandlung der chronischen polyarthritis |
| EP0621273B1 (de) * | 1992-09-18 | 1998-12-09 | Toray Industries, Inc. | Sulfonsäure derivat und deren pharmazeutische verwendung |
| JPH07126161A (ja) * | 1993-10-29 | 1995-05-16 | Toray Ind Inc | 心不全治療剤 |
| JP3541417B2 (ja) * | 1994-02-24 | 2004-07-14 | 日産化学工業株式会社 | フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法 |
| PT742011E (pt) * | 1994-11-17 | 2002-10-31 | Toray Industries | Preparacao que pode ser absorvida por via percutanea |
| JP4062743B2 (ja) * | 1995-02-27 | 2008-03-19 | 東レ株式会社 | 「肺性心治療剤」 |
| CZ168896A3 (en) * | 1995-06-27 | 1997-01-15 | Egyt Gyogyszervegyeszeti Gyar | Oxaindene derivatives and process for preparing thereof |
| DE19530884C2 (de) * | 1995-08-11 | 1997-07-31 | Schering Ag | Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis |
| EP0842663A4 (de) | 1996-05-07 | 2003-06-18 | Toray Industries | Ophtalmika |
| EP0867185B1 (de) * | 1996-09-17 | 2002-06-12 | Toray Industries, Inc. | Verstärker der blutplättchenfunktionund verfahren zur behandlung der blut plättchenfunktionsstörung |
| CN1224354A (zh) * | 1997-02-27 | 1999-07-28 | 东丽株式会社 | 肺循环改善剂 |
| CA2254925A1 (en) * | 1997-03-13 | 1998-09-17 | Shigeyasu Annoh | Drugs for relieving diabetic vascular lesion |
| ATE433753T1 (de) * | 1997-03-14 | 2009-07-15 | Toray Industries | Zusammensetzung von prostaglandin-i-derivaten mit verzoegerter abgabe |
| US6653345B2 (en) | 1997-09-16 | 2003-11-25 | Toray Industries, Inc. | C-C chemokine synthesis inhibitor |
| CN1173742C (zh) | 1997-12-26 | 2004-11-03 | 山之内制药株式会社 | 缓释药物组合物 |
| JP4019481B2 (ja) | 1998-01-23 | 2007-12-12 | ソニー株式会社 | 情報処理装置および方法、情報処理システム、並びに提供媒体 |
| CA2306567A1 (en) * | 1998-08-12 | 2000-02-24 | Sho-Ichi Yamagishi | Plasminogen activator inhibitor-1 production inhibitor |
| WO2000009135A1 (fr) * | 1998-08-14 | 2000-02-24 | Toray Industries, Inc. | Agents de protection des cellules péridermiques |
| US20030092760A1 (en) * | 2001-03-12 | 2003-05-15 | Toray Industries, Inc. | Therapeutic agent for renal failure |
| HU227157B1 (en) * | 2001-07-30 | 2010-09-28 | Chinoin Gyogyszer Es Vegyeszet | Production of beraprost ester by selective oxidation |
| JP3340732B1 (ja) * | 2001-10-05 | 2002-11-05 | 日本医薬品工業株式会社 | シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物 |
| GB0215757D0 (en) * | 2002-07-08 | 2002-08-14 | Cascade Biochem Ltd | Benzoprostacyclin intermediates methods for their preparation and products derived therefrom |
| CA2529351C (en) | 2003-05-09 | 2012-04-17 | Toray Industries, Inc. | Use of prostaglandin i for enhancing the effect of a renin-angiotensin system inhibitor on a renal disease |
| JP4157889B2 (ja) * | 2003-06-25 | 2008-10-01 | 有限会社 循環器研究所 | 性交機能改善用外用製剤 |
| US9783518B2 (en) | 2005-07-08 | 2017-10-10 | Toray Industries, Inc. | Therapeutic agent and treatment method for ameliorating uremia |
| JP5424291B2 (ja) * | 2006-03-03 | 2014-02-26 | 独立行政法人国立循環器病研究センター | 骨髄細胞の動員剤および動員方法 |
| EP2094273B1 (de) * | 2006-11-16 | 2013-03-06 | Gemmus Pharma Inc. | EP2- und EP4-Agonisten als Mittel zur Behandlung von viraler Influenza A Infektion |
| CN102099026B (zh) | 2008-08-13 | 2012-08-29 | 埃科特莱茵药品有限公司 | 含美西特田的治疗组合物 |
| US20120190637A1 (en) | 2009-10-14 | 2012-07-26 | Gemmus Pharma, Inc. | Combination therapy treatment for viral infections |
| EP2500020B1 (de) | 2009-11-13 | 2014-09-10 | Toray Industries, Inc. | Therapeutischer oder prophylaktischer wirkstoff gegen diabetes |
| CA2839424C (en) | 2011-06-16 | 2020-04-07 | Lung LLC | Method of producing beraprost |
| CN103509044A (zh) * | 2012-06-21 | 2014-01-15 | 上海天伟生物制药有限公司 | 贝前列素钠中间体及其制备方法 |
| EP2875022B1 (de) * | 2012-07-19 | 2016-10-12 | Cayman Chemical Company, Incorporated | Difluorlactamverbindungen als ep4-rezeptorselektive agonisten zur verwendung bei der behandlung von ep4-vermittelten erkrankungen und zuständen |
| CN103242274B (zh) * | 2013-05-22 | 2014-11-05 | 孙威 | 一种贝前列素钠化合物及其制备方法 |
| CA2920856A1 (en) | 2013-08-09 | 2015-02-12 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| JP6440896B2 (ja) | 2015-08-12 | 2018-12-19 | ユナイテッド セラピューティクス コーポレイション | ベラプロストを作製するための方法 |
| KR101777632B1 (ko) | 2016-04-11 | 2017-09-12 | 연성정밀화학(주) | 베라프로스트 나트륨 결정형 및 이의 제조방법 |
| CN106632372B (zh) * | 2016-09-26 | 2019-04-02 | 上海北卡医药技术有限公司 | 一种中间体及其制备方法和用途 |
| US10912778B2 (en) | 2016-12-14 | 2021-02-09 | Respira Therapeutics, Inc. | Methods for treatment of pulmonary hypertension |
| CN107325122B (zh) * | 2017-01-06 | 2020-05-01 | 常州博海威医药科技股份有限公司 | 制备贝前列腺素的新中间体及其制备方法 |
| CA3070805A1 (en) | 2017-07-27 | 2019-01-31 | Allergan, Inc. | Prostacyclin receptor agonists for reduction of body fat |
| CN109305986B (zh) * | 2018-11-13 | 2021-02-19 | 济南康和医药科技有限公司 | 一种贝前列素钠中间体的合成方法 |
| US10577340B1 (en) * | 2018-11-26 | 2020-03-03 | Chirogate International Inc. | Beraprost-314d crystals and methods for preparation thereof |
| US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
| CN110746450A (zh) * | 2019-09-17 | 2020-02-04 | 济南康和医药科技有限公司 | 一种贝前列素钠关键中间体的合成方法 |
| CN112569181B (zh) * | 2019-09-27 | 2023-03-21 | 中国科学院上海高等研究院 | 一种快速增溶肾上腺素的方法 |
| TW202317089A (zh) | 2021-06-16 | 2023-05-01 | 日商東麗股份有限公司 | 罹患慢性腎臟病的貓的治療方法 |
| TW202317527A (zh) * | 2021-06-28 | 2023-05-01 | 日商大內新興化學工業股份有限公司 | 貝前列素或光學活性物之合成中間物及其製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2734791A1 (de) * | 1977-07-29 | 1979-02-15 | Schering Ag | Neue prostaglandin-i tief 2 -derivate und verfahren zu ihrer herstellung |
| JPS5931510B2 (ja) * | 1979-09-03 | 1984-08-02 | 東レ株式会社 | ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体 |
| JPS57144276A (en) * | 1981-03-03 | 1982-09-06 | Toray Ind Inc | 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative |
-
1982
- 1982-01-20 JP JP57006150A patent/JPS58124778A/ja active Granted
-
1983
- 1983-01-18 ZA ZA83328A patent/ZA83328B/xx unknown
- 1983-01-19 EP EP83100449A patent/EP0084856B2/de not_active Expired - Lifetime
- 1983-01-19 DE DE8383100449T patent/DE3367774D1/de not_active Expired
- 1983-01-19 AU AU10609/83A patent/AU556348B2/en not_active Expired
- 1983-01-19 US US06/459,226 patent/US4474802A/en not_active Expired - Lifetime
- 1983-01-19 AT AT83100449T patent/ATE23716T1/de not_active IP Right Cessation
- 1983-01-20 CA CA000419895A patent/CA1226280A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU1060983A (en) | 1983-07-28 |
| CA1226280A (en) | 1987-09-01 |
| ZA83328B (en) | 1983-10-26 |
| AU556348B2 (en) | 1986-10-30 |
| EP0084856A1 (de) | 1983-08-03 |
| US4474802A (en) | 1984-10-02 |
| JPH0153672B2 (de) | 1989-11-15 |
| EP0084856B2 (de) | 1994-05-04 |
| ATE23716T1 (de) | 1986-12-15 |
| JPS58124778A (ja) | 1983-07-25 |
| EP0084856B1 (de) | 1986-11-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3367774D1 (de) | 5,6,7-trinor-4, 8-inter-m-phenylene prostaglandin i2 derivatives | |
| ES8401754A1 (es) | "procedimiento de preparar derivados sulfonato". | |
| PT77410B (en) | Process for the preparation of a fungicidal composition containing substituted 1-hydroxymethyltriazolyl derivatives | |
| ES8503667A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina. | |
| ES8505518A1 (es) | Procedimiento para preparar derivados de aminoacidos | |
| JPS5750989A (en) | Imidazole compound | |
| MX9206127A (es) | Compuestos de acetileno | |
| AU550340B2 (en) | Dibenzazepine derivatives | |
| DE3266845D1 (en) | Hydrocortisone derivatives, their preparation and their utilization | |
| AU562253B2 (en) | Thiazolothienoazepine or pyridiue derivatives | |
| ZA84261B (en) | Bicyclo(4.2.0)1,3,5-octatriene derivatives,a process for their preparation and pharmaceutical compositions containing them | |
| ES8401008A1 (es) | Procedimiento para la preparacion de derivados de carbaciclina. | |
| ES8305758A1 (es) | "un procedimiento para la preparacion de 2-(1,4-benzodioxan-2-il-metil)-imidazolina". | |
| DE3264556D1 (en) | Sulfimines, their salts and their preparation, and pharmaceutical compositions containing them | |
| DE3363575D1 (en) | Furyloxazolylacetic acid derivatives, process for preparing same and pharmaceutical compositions containing same | |
| JPS52100470A (en) | Synthesis of hydantoin derivatives | |
| ES8705426A1 (es) | Un procedimiento para la preparacion de un derivado de piperazina. | |
| ES8607944A1 (es) | Procedimiento para la preparacion de nuevos derivados de 1- fenilimidazolidin-2-ona | |
| FI852465L (fi) | Selektiva, biologiskt aktiva 7-oxo- prostacyklin-derivat samt framstaellningsfoerfarande foer dessa samt dessa innehaollande farmaceutiska kompositioner. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings |