CN103608018A - 取代的2,3-二氢咪唑并[1,2-c]喹唑啉的用途 - Google Patents

取代的2,3-二氢咪唑并[1,2-c]喹唑啉的用途 Download PDF

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Publication number
CN103608018A
CN103608018A CN201280027514.5A CN201280027514A CN103608018A CN 103608018 A CN103608018 A CN 103608018A CN 201280027514 A CN201280027514 A CN 201280027514A CN 103608018 A CN103608018 A CN 103608018A
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glyoxalidine
quinazoline
methoxyl group
group
morpholine
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CN201280027514.5A
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Chinese (zh)
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CN103608018B (zh
Inventor
刘宁姝
C·施奈德
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Bayer Pharma AG
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Bayer Pharma AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
CN201280027514.5A 2011-04-05 2012-03-29 取代的2,3‑二氢咪唑并[1,2‑c]喹唑啉的用途 Expired - Fee Related CN103608018B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11161142 2011-04-05
EP11161142.2 2011-04-05
PCT/EP2012/055595 WO2012136549A1 (en) 2011-04-05 2012-03-29 Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines

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CN103608018A true CN103608018A (zh) 2014-02-26
CN103608018B CN103608018B (zh) 2017-06-30

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US (1) US10202385B2 (und)
EP (1) EP2694069A1 (und)
JP (1) JP6013446B2 (und)
KR (1) KR102006033B1 (und)
CN (1) CN103608018B (und)
AP (1) AP3751A (und)
AR (1) AR088730A1 (und)
AU (2) AU2012238887A1 (und)
BR (1) BR112013025517A2 (und)
CA (1) CA2832120C (und)
CL (1) CL2013002869A1 (und)
CU (1) CU24349B1 (und)
DO (1) DOP2013000224A (und)
EA (1) EA027670B1 (und)
EC (1) ECSP13013007A (und)
GT (1) GT201300235A (und)
IL (1) IL228435A0 (und)
JO (1) JO3733B1 (und)
MA (1) MA35015B1 (und)
MX (1) MX2013011582A (und)
MY (1) MY169532A (und)
PE (1) PE20140571A1 (und)
SG (1) SG193577A1 (und)
TN (1) TN2013000402A1 (und)
TW (1) TWI639599B (und)
UA (1) UA114177C2 (und)
UY (1) UY33984A (und)
WO (1) WO2012136549A1 (und)

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CU24349B1 (es) 2018-06-05
PE20140571A1 (es) 2014-05-19
US20140243295A1 (en) 2014-08-28
AU2017203474A1 (en) 2017-06-08
KR20140025427A (ko) 2014-03-04
MA35015B1 (fr) 2014-04-03
GT201300235A (es) 2014-08-27
DOP2013000224A (es) 2013-11-15
TN2013000402A1 (en) 2015-03-30
SG193577A1 (en) 2013-10-30
AP2013007147A0 (en) 2013-09-30
JO3733B1 (ar) 2021-01-31
UY33984A (es) 2012-10-31
UA114177C2 (uk) 2017-05-10
JP2014514297A (ja) 2014-06-19
TWI639599B (zh) 2018-11-01
ECSP13013007A (es) 2013-12-31
CA2832120C (en) 2020-10-27
AU2012238887A1 (en) 2013-10-10
MY169532A (en) 2019-04-22
CU20130134A7 (es) 2014-01-29
MX2013011582A (es) 2014-05-01
IL228435A0 (en) 2013-12-31
CN103608018B (zh) 2017-06-30
EA201301106A1 (ru) 2014-03-31
US10202385B2 (en) 2019-02-12
WO2012136549A1 (en) 2012-10-11
NZ615502A (en) 2016-03-31
CL2013002869A1 (es) 2014-07-18
KR102006033B1 (ko) 2019-07-31
EP2694069A1 (en) 2014-02-12
AU2017203474B2 (en) 2019-03-21
TW201245202A (en) 2012-11-16
AP3751A (en) 2016-07-31
BR112013025517A2 (pt) 2016-12-27
AR088730A1 (es) 2014-07-02
EA027670B1 (ru) 2017-08-31
CA2832120A1 (en) 2012-10-11
JP6013446B2 (ja) 2016-10-25

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