CN103214489B - 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法 - Google Patents
一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法 Download PDFInfo
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CN103214489A CN103214489A (zh) | 2013-07-24 |
CN103214489B true CN103214489B (zh) | 2016-10-26 |
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Families Citing this family (1)
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CN104788484B (zh) * | 2015-04-30 | 2017-01-11 | 杭州拜善晟生物科技有限公司 | 一种2-硝基苯基硼酸的合成方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1198743A (zh) * | 1995-10-02 | 1998-11-11 | 弗·哈夫曼-拉罗切有限公司 | 作为5HT2c-受体拮抗剂的嘧啶衍生物 |
WO2003050090A1 (en) * | 2001-11-27 | 2003-06-19 | Wyeth Holdings Corporation | 3-cyanoquinolines as inhibitors of egf-r and her2 kinases |
CN101631464A (zh) * | 2006-12-05 | 2010-01-20 | 拜耳先灵医药股份有限公司 | 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物 |
CN102906094A (zh) * | 2010-11-11 | 2013-01-30 | 拜耳知识产权有限责任公司 | 用于治疗过度增殖性病症和与血管发生相关的疾病的氨基醇取代的2,3-二氢咪唑并[1,2-c]喹唑啉衍生物 |
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- 2013-02-25 CN CN201310060319.9A patent/CN103214489B/zh not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1198743A (zh) * | 1995-10-02 | 1998-11-11 | 弗·哈夫曼-拉罗切有限公司 | 作为5HT2c-受体拮抗剂的嘧啶衍生物 |
WO2003050090A1 (en) * | 2001-11-27 | 2003-06-19 | Wyeth Holdings Corporation | 3-cyanoquinolines as inhibitors of egf-r and her2 kinases |
CN101631464A (zh) * | 2006-12-05 | 2010-01-20 | 拜耳先灵医药股份有限公司 | 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物 |
CN102906094A (zh) * | 2010-11-11 | 2013-01-30 | 拜耳知识产权有限责任公司 | 用于治疗过度增殖性病症和与血管发生相关的疾病的氨基醇取代的2,3-二氢咪唑并[1,2-c]喹唑啉衍生物 |
Non-Patent Citations (4)
Title |
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Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles;Mizuhara, Tsukasa 等;《Organic & Biomolecular Chemistry》;20120622;第10卷(第33期);第2649-2658页 * |
Rapid Access to Pyrimido[5,4-c]isoquinolines via a Sulfur Monoxide Extrusion Reaction;Renzhong Fu 等;《ORGANIC LETTERS》;20070120;第9卷(第4期);第571-574页 * |
Synthesis of 2,4-Diaminoquinazolines and Tricyclic Quinazolines by Cascade Reductive Cyclization of Methyl N-Cyano-2-nitrobenzimidates;Ping Yin 等;《The Journal of Organic Chemistry》;20120127;第77卷(第6期);第6792-6802页 * |
具新生血管抑制及血管阻断双重作用的肿瘤血管靶向药物研究进展;周峰 等;《药学进展》;20130115;第37卷(第1期);第17-23页 * |
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CN103214489A (zh) | 2013-07-24 |
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