CN103214489A - 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法 - Google Patents

一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法 Download PDF

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CN103214489A
CN103214489A CN2013100603199A CN201310060319A CN103214489A CN 103214489 A CN103214489 A CN 103214489A CN 2013100603199 A CN2013100603199 A CN 2013100603199A CN 201310060319 A CN201310060319 A CN 201310060319A CN 103214489 A CN103214489 A CN 103214489A
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phenyl
group
amine
base
pyrimidine
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CN103214489B (zh
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周有骏
周峰
李唯
刘嘉
陈莎娜
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Second Military Medical University SMMU
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CN201310060319.9A 2013-02-25 2013-02-25 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法 Expired - Fee Related CN103214489B (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104788484A (zh) * 2015-04-30 2015-07-22 杭州拜善晟生物科技有限公司 一种2-硝基苯基硼酸的合成方法

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WO2003050090A1 (en) * 2001-11-27 2003-06-19 Wyeth Holdings Corporation 3-cyanoquinolines as inhibitors of egf-r and her2 kinases
CN101631464A (zh) * 2006-12-05 2010-01-20 拜耳先灵医药股份有限公司 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN102906094A (zh) * 2010-11-11 2013-01-30 拜耳知识产权有限责任公司 用于治疗过度增殖性病症和与血管发生相关的疾病的氨基醇取代的2,3-二氢咪唑并[1,2-c]喹唑啉衍生物

Patent Citations (5)

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CN1198743A (zh) * 1995-10-02 1998-11-11 弗·哈夫曼-拉罗切有限公司 作为5HT2c－受体拮抗剂的嘧啶衍生物
WO2003050090A1 (en) * 2001-11-27 2003-06-19 Wyeth Holdings Corporation 3-cyanoquinolines as inhibitors of egf-r and her2 kinases
CN101631464A (zh) * 2006-12-05 2010-01-20 拜耳先灵医药股份有限公司 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
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Title
MIZUHARA, TSUKASA 等: "Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles", 《ORGANIC & BIOMOLECULAR CHEMISTRY》, vol. 10, no. 33, 22 June 2012 (2012-06-22) *
PING YIN 等: "Synthesis of 2,4-Diaminoquinazolines and Tricyclic Quinazolines by Cascade Reductive Cyclization of Methyl N-Cyano-2-nitrobenzimidates", 《THE JOURNAL OF ORGANIC CHEMISTRY》, vol. 77, no. 6, 27 January 2012 (2012-01-27) *
RENZHONG FU 等: "Rapid Access to Pyrimido[5,4-c]isoquinolines via a Sulfur Monoxide Extrusion Reaction", 《ORGANIC LETTERS》, vol. 9, no. 4, 20 January 2007 (2007-01-20) *
周峰 等: "具新生血管抑制及血管阻断双重作用的肿瘤血管靶向药物研究进展", 《药学进展》, vol. 37, no. 1, 15 January 2013 (2013-01-15) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104788484A (zh) * 2015-04-30 2015-07-22 杭州拜善晟生物科技有限公司 一种2-硝基苯基硼酸的合成方法
CN104788484B (zh) * 2015-04-30 2017-01-11 杭州拜善晟生物科技有限公司 一种2-硝基苯基硼酸的合成方法

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