CN102906094A - 用于治疗过度增殖性病症和与血管发生相关的疾病的氨基醇取代的2,3-二氢咪唑并[1,2-c]喹唑啉衍生物 - Google Patents

用于治疗过度增殖性病症和与血管发生相关的疾病的氨基醇取代的2,3-二氢咪唑并[1,2-c]喹唑啉衍生物 Download PDF

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Publication number: CN102906094A
Authority: CN; China
Prior art keywords: alkyl; quinazoline; glyoxalidine; methoxyl group; hydroxyl
Prior art date: 2010-11-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CN2011800231227A

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English (en)

Chinese (zh)

Other versions

CN102906094B (zh

Inventor

W·斯科特

刘宁姝

M·默维斯

A·哈格巴尔特

U·门宁

U·伯默

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Intellectual Property GmbH

Original Assignee

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-11-11

Filing date

2011-11-08

Publication date

2013-01-30

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2011-11-08 Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG

2013-01-30 Publication of CN102906094A publication Critical patent/CN102906094A/zh

2016-06-22 Application granted granted Critical

2016-06-22 Publication of CN102906094B publication Critical patent/CN102906094B/zh

Status Active legal-status Critical Current

2031-11-08 Anticipated expiration legal-status Critical

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Classifications

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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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CN201180023122.7A 2010-11-11 2011-11-08 用于治疗过度增殖性病症和与血管发生相关的疾病的氨基醇取代的2,3-二氢咪唑并[1,2-c]喹唑啉衍生物 Active CN102906094B (zh)

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US41255610P	2010-11-11	2010-11-11
US61/412,556		2010-11-11
PCT/EP2011/069637 WO2012062748A1 (en)	2010-11-11	2011-11-08	Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

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US (2)	US8895549B2 (und)
EP (1)	EP2638045B1 (und)
JP (1)	JP6196156B2 (und)
KR (1)	KR20140003436A (und)
CN (1)	CN102906094B (und)
AP (1)	AP3337A (und)
AR (1)	AR083842A1 (und)
AU (1)	AU2011328192B2 (und)
BR (1)	BR112013011634A2 (und)
CA (1)	CA2817317C (und)
CL (1)	CL2013001295A1 (und)
CO (1)	CO6761350A2 (und)
CR (1)	CR20130213A (und)
CU (1)	CU20130069A7 (und)
DO (1)	DOP2013000105A (und)
EA (1)	EA024406B1 (und)
EC (1)	ECSP13012618A (und)
GT (1)	GT201300121A (und)
HK (1)	HK1180685A1 (und)
IL (1)	IL226066A0 (und)
MA (1)	MA34655B1 (und)
MX (1)	MX2013005305A (und)
MY (1)	MY164730A (und)
NZ (1)	NZ610018A (und)
PE (1)	PE20140411A1 (und)
SG (1)	SG190100A1 (und)
TW (1)	TW201305170A (und)
UA (1)	UA113280C2 (und)
UY (1)	UY33719A (und)
WO (1)	WO2012062748A1 (und)
ZA (1)	ZA201304244B (und)

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CN105263497A (zh) *	2013-04-08	2016-01-20	拜耳制药股份公司	取代的2,3-二氢咪唑并[1,2-c]喹唑啉治疗淋巴瘤的用途
CN108383849A (zh) *	2018-04-26	2018-08-10	浙江大学	咪唑并喹唑啉衍生物及其在抗肿瘤抗炎中的应用
CN113518775A (zh) *	2019-03-07	2021-10-19	生物技术公司	用于制备经取代的咪唑并喹啉的方法
CN113512040A (zh) *	2021-08-25	2021-10-19	河南牧业经济学院	一种新型血根碱仿生类似物及其制备方法

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CN105263497B (zh) *	2013-04-08	2019-04-30	拜耳制药股份公司	取代的2,3-二氢咪唑并[1,2-c]喹唑啉治疗淋巴瘤的用途
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