CN101631464A - 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物 - Google Patents

用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物 Download PDF

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CN101631464A
CN101631464A CN200780044849A CN200780044849A CN101631464A CN 101631464 A CN101631464 A CN 101631464A CN 200780044849 A CN200780044849 A CN 200780044849A CN 200780044849 A CN200780044849 A CN 200780044849A CN 101631464 A CN101631464 A CN 101631464A
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glyoxalidine
quinazoline
methoxyl group
group
morpholine
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Chinese (zh)
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CN101631464B (zh
Inventor
M·亨特曼
J·伍德
W·斯科特
M·米歇尔斯
A-M·坎贝尔
A-M·比利翁
R·B·罗利
A·雷德曼
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Bayer Intellectual Property GmbH
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Schering AG
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Priority to CN202211453281.7A priority Critical patent/CN115724847A/zh
Priority to CN201510632842.3A priority patent/CN105254634B/zh
Priority to CN201810535933.9A priority patent/CN108774232B/zh
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
CN200780044849.7A 2006-12-05 2007-12-05 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物 Active CN101631464B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202211453281.7A CN115724847A (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN201510632842.3A CN105254634B (zh) 2006-12-05 2007-12-05 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN201810535933.9A CN108774232B (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87309006P 2006-12-05 2006-12-05
US60/873,090 2006-12-05
PCT/US2007/024985 WO2008070150A1 (en) 2006-12-05 2007-12-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

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CN202211453281.7A Division CN115724847A (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN201810535933.9A Division CN108774232B (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN201510632842.3A Division CN105254634B (zh) 2006-12-05 2007-12-05 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物

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CN101631464A true CN101631464A (zh) 2010-01-20
CN101631464B CN101631464B (zh) 2022-12-06

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CN200780044849.7A Active CN101631464B (zh) 2006-12-05 2007-12-05 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN201510632842.3A Active CN105254634B (zh) 2006-12-05 2007-12-05 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN202211453281.7A Pending CN115724847A (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN201810535933.9A Active CN108774232B (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物

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CN201510632842.3A Active CN105254634B (zh) 2006-12-05 2007-12-05 用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN202211453281.7A Pending CN115724847A (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物
CN201810535933.9A Active CN108774232B (zh) 2006-12-05 2007-12-05 2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物

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JP (1) JP5326092B2 (und)
KR (1) KR101501785B1 (und)
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CN102906094A (zh) * 2010-11-11 2013-01-30 拜耳知识产权有限责任公司 用于治疗过度增殖性病症和与血管发生相关的疾病的氨基醇取代的2,3-二氢咪唑并[1,2-c]喹唑啉衍生物
CN103214489A (zh) * 2013-02-25 2013-07-24 中国人民解放军第二军医大学 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法
CN103339133A (zh) * 2010-11-11 2013-10-02 拜耳知识产权有限责任公司 烷氧基取代的2,3-二氢咪唑并[1,2-c]喹唑啉
CN103370320A (zh) * 2010-11-11 2013-10-23 拜耳知识产权有限责任公司 芳基氨基醇取代的2,3-二氢咪唑并[1,2-c]喹啉
CN103608018A (zh) * 2011-04-05 2014-02-26 拜耳知识产权有限责任公司 取代的2,3-二氢咪唑并[1,2-c]喹唑啉的用途
CN103649091A (zh) * 2011-04-05 2014-03-19 拜耳知识产权有限责任公司 取代的2,3-二氢咪唑并[1,2-c]喹唑啉盐
CN104582732A (zh) * 2012-06-15 2015-04-29 布里格姆及妇女医院股份有限公司 治疗癌症的组合物及其制造方法
CN104557955A (zh) * 2013-10-23 2015-04-29 上海汇伦生命科技有限公司 作为PI3K/mTOR抑制剂的三环类化合物,其制备方法和用途
CN105130998A (zh) * 2015-09-25 2015-12-09 苏州立新制药有限公司 库潘尼西的制备方法
CN105130997A (zh) * 2015-09-25 2015-12-09 苏州明锐医药科技有限公司 一种库潘尼西的制备方法
CN105263497A (zh) * 2013-04-08 2016-01-20 拜耳制药股份公司 取代的2,3-二氢咪唑并[1,2-c]喹唑啉治疗淋巴瘤的用途
CN105934256A (zh) * 2013-12-03 2016-09-07 拜耳制药股份公司 Pi3k-抑制剂的组合产品
CN106177918A (zh) * 2016-09-30 2016-12-07 广州赛莱拉干细胞科技股份有限公司 一种间充质干细胞注射液及其制备方法和应用
CN107074776A (zh) * 2014-11-07 2017-08-18 拜耳制药股份公司 Copanlisib及其二盐酸盐的合成
CN107278204A (zh) * 2014-11-07 2017-10-20 拜耳制药股份公司 Copanlisib及其二盐酸盐的合成
CN107864625A (zh) * 2015-03-09 2018-03-30 拜耳制药股份公司 含有取代的2,3‑二氢咪唑并[1,2‑c]喹唑啉的组合产品
CN108368117A (zh) * 2016-06-08 2018-08-03 深圳市塔吉瑞生物医药有限公司 一种取代的咪唑并喹唑啉化合物及其药物组合物
CN108383849A (zh) * 2018-04-26 2018-08-10 浙江大学 咪唑并喹唑啉衍生物及其在抗肿瘤抗炎中的应用
CN109516961A (zh) * 2018-12-25 2019-03-26 浙江大学 氨基喹唑啉酮和氨基异喹啉酮衍生物及其应用
CN110269941A (zh) * 2012-11-02 2019-09-24 Tg疗法有限公司 抗cd20抗体和pi3激酶选择性抑制剂的组合
CN112047960A (zh) * 2015-07-02 2020-12-08 豪夫迈·罗氏有限公司 苯并氧氮杂*噁唑烷酮化合物及其使用方法

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* Cited by examiner, † Cited by third party
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EP2244721A4 (en) * 2008-01-14 2017-01-18 Bayer Intellectual Property GmbH Sulfone substituted 2,3-dihydroimidazo ý1,2-c¨quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis
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