CA2671614A1 - Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis - Google Patents

Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis Download PDF

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Publication number
CA2671614A1
CA2671614A1 CA002671614A CA2671614A CA2671614A1 CA 2671614 A1 CA2671614 A1 CA 2671614A1 CA 002671614 A CA002671614 A CA 002671614A CA 2671614 A CA2671614 A CA 2671614A CA 2671614 A1 CA2671614 A1 CA 2671614A1
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Prior art keywords
methoxy
dihydroimidazo
quinazolin
morpholin
ylpropoxy
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CA002671614A
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English (en)
French (fr)
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CA2671614C (en
Inventor
Martin Hentemann
Jill Wood
William Scott
Martin Michels
Ann-Marie Campbell
Ann-Marie Bullion
R. Bruce ROWLEY
Aniko Redman
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Bayer Intellectual Property GmbH
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
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    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
CA2671614A 2006-12-05 2007-12-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis Active CA2671614C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87309006P 2006-12-05 2006-12-05
US60/873,090 2006-12-05
PCT/US2007/024985 WO2008070150A1 (en) 2006-12-05 2007-12-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Publications (2)

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CA2671614A1 true CA2671614A1 (en) 2008-06-12
CA2671614C CA2671614C (en) 2016-01-26

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CA2671614A Active CA2671614C (en) 2006-12-05 2007-12-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

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US (3) USRE46856E1 (und)
EP (1) EP2096919B1 (und)
JP (1) JP5326092B2 (und)
KR (1) KR101501785B1 (und)
CN (4) CN101631464B (und)
AR (1) AR064106A1 (und)
AU (1) AU2007328008B2 (und)
BR (1) BRPI0720178B8 (und)
CA (1) CA2671614C (und)
CL (1) CL2007003508A1 (und)
CO (1) CO6220908A2 (und)
CR (1) CR10838A (und)
CU (1) CU23796B7 (und)
DK (1) DK2096919T3 (und)
DO (1) DOP2009000135A (und)
EA (1) EA018839B1 (und)
EC (1) ECSP099387A (und)
ES (1) ES2572189T3 (und)
GT (1) GT200900154A (und)
HK (1) HK1217953A1 (und)
HN (1) HN2009001131A (und)
HU (1) HUE028773T2 (und)
IL (1) IL198273A (und)
JO (1) JO3147B1 (und)
MA (1) MA31283B1 (und)
MX (1) MX2009006001A (und)
MY (1) MY157944A (und)
NO (1) NO342348B1 (und)
NZ (1) NZ577342A (und)
PA (1) PA8759601A1 (und)
PE (1) PE20081444A1 (und)
PL (1) PL2096919T3 (und)
RS (1) RS56045B1 (und)
SG (1) SG177170A1 (und)
SI (1) SI2096919T1 (und)
SV (1) SV2009003288A (und)
TN (1) TN2009000137A1 (und)
TW (1) TWI406662B (und)
UA (1) UA96965C2 (und)
UY (1) UY30761A1 (und)
WO (1) WO2008070150A1 (und)
ZA (1) ZA200904691B (und)

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