CA2279796A1 - Process for the preparation of substituted pyridines - Google Patents

Process for the preparation of substituted pyridines Download PDF

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Publication number
CA2279796A1
CA2279796A1 CA002279796A CA2279796A CA2279796A1 CA 2279796 A1 CA2279796 A1 CA 2279796A1 CA 002279796 A CA002279796 A CA 002279796A CA 2279796 A CA2279796 A CA 2279796A CA 2279796 A1 CA2279796 A1 CA 2279796A1
Authority
CA
Canada
Prior art keywords
preparation
substituted pyridines
formula
carbamoylation
concerned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002279796A
Other languages
French (fr)
Other versions
CA2279796C (en
Inventor
Uwe Klinkhammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2279796A1 publication Critical patent/CA2279796A1/en
Application granted granted Critical
Publication of CA2279796C publication Critical patent/CA2279796C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

The present invention is concerned with a novel process for the carbamoylation of substituted pyridines, especially with a process for the preparation of compounds of formula I
(see formula I) wherein R4 to R8 represent hydrogen, lower-alkoxy or halogen;
or optionally salts thereof.
CA002279796A 1998-08-10 1999-08-06 Process for the preparation of substituted pyridines Expired - Lifetime CA2279796C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98114978.4 1998-08-10
EP98114978 1998-08-10

Publications (2)

Publication Number Publication Date
CA2279796A1 true CA2279796A1 (en) 2000-02-10
CA2279796C CA2279796C (en) 2003-09-30

Family

ID=8232437

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002279796A Expired - Lifetime CA2279796C (en) 1998-08-10 1999-08-06 Process for the preparation of substituted pyridines

Country Status (10)

Country Link
US (1) US6103902A (en)
EP (1) EP0979822B1 (en)
JP (1) JP3344972B2 (en)
KR (1) KR100362081B1 (en)
CN (1) CN1117746C (en)
AT (1) ATE311382T1 (en)
CA (1) CA2279796C (en)
DE (1) DE69928610T2 (en)
DK (1) DK0979822T3 (en)
ES (1) ES2252894T3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
CN105669542A (en) * 2016-03-08 2016-06-15 南京师范大学 Method for synthesizing pyridine primary amides by direct catalytic oxidation process
WO2022096549A1 (en) 2020-11-05 2022-05-12 Idorsia Pharmaceuticals Ltd A stable crystalline hydrate of clazosentan disodium salt
TW202329952A (en) 2021-12-17 2023-08-01 瑞士商愛杜西亞製藥有限公司 A process for the preparation of clazosentan disodium salt

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW313568B (en) * 1994-12-20 1997-08-21 Hoffmann La Roche

Also Published As

Publication number Publication date
CN1117746C (en) 2003-08-13
KR100362081B1 (en) 2002-11-23
CN1245803A (en) 2000-03-01
JP2000063377A (en) 2000-02-29
ES2252894T3 (en) 2006-05-16
US6103902A (en) 2000-08-15
EP0979822B1 (en) 2005-11-30
CA2279796C (en) 2003-09-30
DE69928610T2 (en) 2006-08-10
KR20000017194A (en) 2000-03-25
DE69928610D1 (en) 2006-01-05
JP3344972B2 (en) 2002-11-18
ATE311382T1 (en) 2005-12-15
EP0979822A1 (en) 2000-02-16
DK0979822T3 (en) 2006-03-27

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20190806