🧠 Multiple sclerosis (MS) is a chronic condition in which the immune system attacks the nervous system, but clinical disease presentations can be diverse, protean, and difficult to manage in more progressive states.
Exercise impacts immunometabolism by altering metabolic pathways such as glycolysis, mitochondrial biogenesis, glutamine anaplerosis, oxidative phosphorylation, fatty acid and amino acid metabolism.
🏃♀️ Exercise induces metabolic changes in immune cells, including AMPK activation, mTOR inhibition, and modulation of the kynurenine pathway, all of which have implications for neuroprotection in MS.
Exercise also positively modulates myokine and adipokine secretion, pro-inflammatory macrophage and effector T cell activity, and oxidative stress levels.
💡Future research may benefit from examining the potential of exercise to serve as an adjunct therapy for MS, alongside pharmacological therapies.
📍REFERENCE: Afzal R, Dowling JK, McCoy CE. Impact of Exercise on Immunometabolism in Multiple Sclerosis. Journal of Clinical Medicine. 2020; 9(9):3038. doi:10.3390/jcm9093038
