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Purpose: To determine the effect alcohol extract of Zataria multiflora, Satureja bachtiarica and Zaravschanica membranacea on immunohematologic factors in Wistar rats. Methods: Wistar rats were randomly allocated to seven treatment groups which consisted of control group with water and feed only (1); 200 mg. kg-1 Z. membranacea (2); 400 mg. kg-1 Z. membranacea (3); 200 mg. kg-1 S. bachtiarica (4); 400 mg. kg-1 S. bachtiarica (5); 200 mg. kg-1 Z. multiflora (6) and 400 mg. kg-1 Z. multiflora (7). Erythrocyte counts (RBC), packed cell volumes (PCV), haemoglobin (Hb) concentration, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), Translocation and Assembly Module (Tam) protein, IgM and albumin were measured after 29 days. Results: Z. membranacea at 200 mg kg-1 showed the highest level of Tam-protein content (p < 0.05). Z. multiflora boiss at 400 mg kg-1 produced higher levels of immunoglobulin M (IgM) compared to S. bachtiarica and Z. multiflora (p < 0.05). Both Z. membranacea and S. bachtiarica at 200 mg. kg-1 caused a significant increase in albumin levels in the rats (p < 0.05). Z. multiflora at 400 mg. kg-1 had the highest effect on white blood cells (WBC) while S. bachtiarica produced the highest effect on neutrophils (Nut) (p < 0.05). Z. membranacea and Z. multiflora at 200 mg. kg-1 showed significantly higher levels of monocytes (Mon) % (p < 0.05). Z. multiflora and S. bachtiarica at 400 mg. kg-1 showed a significant effect on phagocytosis % (p < 0.05) whilst S. bachtiarica at 400 mg.kg-1 had a significant effect on phagocytosis number (p < 0.05). Conclusion: The alcohol extracts of Z. multiflora Z. membranacea and S. bachtiarica extracts are capable of stimulating the immune defense mechanism without causing undesirable effects on hematological parameters.
ADVANCED STUDIES IN BIOLOGY
Effect of Zataria multiflora bosis alcoholic extract on some components of complement system and serum IgM in rat2014 •
Common thyme with scientific name Thymus vulgaris is one of the Iran indigenous plants that exist widely in southern and central regions of country. This plant has medical applications in traditional medicine including antibacterial and antifungal activity affecting gastrointestinal and chronic diseases. All Thymuses are rich in terms of volatile compounds and mainly consist of thymol and Carvacrol that are considered as strong disinfectants. With regard to valuable properties of common thyme, we decided to investigate effects of Zataria multiflora bosis alcoholic extract on some components of Complement system (c1inhibitor, CH50, C3, C4) and serum IgM in rat. In this research two treatment groups were fed with Zataria multiflora bosis alcoholic extract at dose of 200 and 400 mg/kg for 30 days and the third group as whiteness did not received no compound. In this study after measuring components of complement system and IgM, CH50 amount in two treatment groups showed a significant increase than the control group(p<0.05). Amount of C1inhibitor also showed a significant increase in the group 1 than the control group (p<0.05). Also amount of IgM in two treatment groups showed a relative increase than the control group.
2019 •
Objective: Oxidative stress leads to reactive oxygen species (ROS) overproduction, which causes tissue injury in diabetic patients. The aim of this study was to evaluate the effects of Zataria multiflora extract on TNF-α, oxidative stress products, and insulin levels as well as lipid profile in diabetic rats. Materials and methods: Rats were randomly divided into 6 groups of 10 animals. Diabetes was induced by a single injection of streptozotocin (STZ). Control and diabetic control rats orally received 1 mL/day of normal saline, whereas the other three groups received 250, 500 and 1000 mg/kg/day of Z. multiflora extract, and one non-diabetic group orally received 1000 mg/kg/day Z. multiflora extract, for 28 days. At the end of the treatment course, rats were anesthetized and their serum samples were analyzed for TNF-α, malondialdehyde (MDA), super oxide dismutase (SOD), total antioxidant capacity (TAC), lipid profile, total plasma protein, blood glucose, insulin, and liver enzymes levels. Results: Our results showed that cholesterol, LDL, TG, MDA and TNF-α levels decreased, but HDL, SOD, TAC, and total protein increased significantly in the diabetic group receiving 1000 mg/kg Z. multiflora compared to the diabetic control group (P<0.05). Moreover, blood glucose level was significantly reduced following administration of different concentrations of Z. multiflora. Liver sections of diabetic rats treated with Z. multiflora 1000 mg/kg showed normal hepatocytes and restoration of liver architecture. Conclusion: Z. multiflora extract ameliorated oxidative stress, TNF-α serum level, lipid abnormality, blood glucose, and liver damage in rats with diabetes mellitus.
Journal of Ethnopharmacology
The impact of Zataria multiflora Boiss extract on in vitro and in vivo Th1/Th2 cytokine (IFN-γ/IL4) balance2013 •
Asian Pacific Journal of Tropical Medicine
Antibacterial activity of ethyl acetate and aqueous extracts of Mentha longifolia L. and hydroalcoholic extract of Zataria multiflora Boiss. plants against important human pathogens2014 •
2000 •
Background: Herbal medicines have been used since ancient times for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity. Objective: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic activity and TNF-α secretion in animal model. Methods: Eight BALB/c mice were divided into two
2007 •
Evidence Based …
Benefits of Zataria multiflora Boiss in experimental model of mouse inflammatory bowel disease2007 •
Zanjan University of Medical Sciences
The Antitumoral Activity of Zataria Multiflora Methanolic Extract on Acute Promyelocytic Leukemia Cell Line; NB4Background & Objective: Zataria multiflora is a plant that belongs to Laminaceae family. It is traditionally believed to have several therapeutic effects. Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia with dominancy of promyelocytes in bone marrow and blood stream. The aim of this study is to investigate the anticancer effects of Z. multiflora extract on acute promyelocytic leukemia cell lines. Materials & Methods: Viability of NB4 cells was determined by trypane blue test after treatment with 20, 40 and 80µg/mL of Z. multiflora extract for 24 hours. Then, the metabolic activity of cells was determined by MTT assay after 24 hours of treatment with 80 µg/mL Z. multiflora. Finally, Real-time PCR was employed to study the effect of Z. multiflora extract on the expression of hTERT gene. Results: Z. multiflora extract decreased the viability of NB4 cells in a dose-dependent manner. Metabolic activity of NB4 cells significantly decreased following treatment with 80 µg/mL Z. multiflora. Gene expression analysis showed 59%±4% decrease in the expression of hTERT gene after treatment with 80 µg/mL of Z. multiflora. Conclusion: Z. multiflora extract significantly decreased the viability and metabolic activity of NB4 cells. It also led to significant downregulation of hTERT gene compared to the control group. Therefore, Z. multiflora methanolic extract potentially has anticancer effect on acute promyelocytic leukemia cells through down regulation of hTERT. Further investigations are needed to explore other mechanisms of actions and the active ingredients.
Journal of Medicine and Life
Preventive effect of methanolic extract of Zataria Multiflora Boiss on liver toxicity of paracetamol in rats2015 •
Background: The analgesic paracetamol causes a potentially fatal, centrilobular hepatic necrosis when taken in misuse and overdose. This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by paracetamol-induced hepatotoxicity in male Wistar rats. Methods: for this purpose, paracetamol was administrated orally at a dose of 2 g/ kg body weight (b.w.)/ day on the seventh day after the oral administration of a methanolic extract of Z. Multiflora at doses of 100 mg/ kg, 200 mg/ kg and 400 mg/ kg b.w. The lipid peroxidation level and activities of liver aminotransferases and enzymes contributing to the oxidative damage were measured in serum, and a histopathological examination of liver sections was also performed. Results and Discussion: The results showed that Z. Multiflora reduced the activity of aminotransferases in rats treated with paracetamol. This extract also inhibited lipid peroxidati...
HIGHLIGHTS Phenolic content in sumac extract (305.65 mg/g) was higher than Zataria multiflora Essential Oil (ZEO) (179.42 mg/g). Sumac extract had more antioxidative activities than ZEO. ZEO showed more antibacterial activities than Sumac extract. ABSTRACT Background: The increasing demand for natural preservatives results in their extended usefulness. The objective of the present study was to investigate the physicochemical and antioxidative characteristics of Rhus coriaria L. (sumac) fruit and comparison of its antioxidative and antibacterial activity with Zataria multiflora Essential Oil (ZEO) as native Iranian natural additives. Methods: Antioxidant activities of Z. multiflora Boiss and sumac were analyzed by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2, 2'-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS). Reducing power tests were used for measuring antioxidant activity. Total phenolic content of extract and essential oil were studied as well. The Minimal Inhibitory Concentration (MIC), Minimal Bactericidal Concentration (MBC), and Fractional Inhibitory Concentration (FIC) of a hydroalcoholic extract of sumac and ZEO against of Salmonella Typhimurium and Listeria monocytogenes were studied. Statistical analysis of data was performed using the SPSS software. Results: The phenolic content in sumac extract (305.65 mg/g) was significantly (p˂0.05) higher than ZEO (179.42 mg/100 g). The highest level of antibacterial activity was demonstrated by ZEO with the MICs of 0.625 for S. Typhimurium and 1.25 mg/ml for L. monocytogenes. Conclusion: Sumac extract showed more potent antioxidative activity than ZEO. However, based on the results of antibacterial activity, ZEO had more potent than sumac extract, significantly.
Acta Universitatis Nicolai Copernici Pedagogika
Sprawozdanie z pobytu stypendialnego przy Polskiej Misji Historycznej w Würzburgu (06.2016)The American Journal of Human Genetics
Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies2015 •
The Journal of nutrition
Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension2002 •
Solid State Ionics
Structural evidence for the interstitialcy mechanism in β-alumina1988 •
2020 •
2014 •
Dossier thématique en ligne sur l’affaire Vincent Lambert, groupe de recherche UTELIB de l’Institut Fédératif de Recherche de l’Université Toulouse 1 Capitole
Les dimensions religieuses de l'affaire Vincent Lambert2016 •
Annals of the Japan Association for Philosophy of Science
Can Scientific Cognition Be Distributed?2017 •
Metodik Didaktik
Engaruh Pendekatan Concrete-Pictorial-Abstract (Cpa) Terhadap Pencapaian Kemampuan Spatial Sense (KSS) Siswa SD2017 •
Acta Otorrinolaringologica (English Edition)
Small round cell desmoplastic tumour. Atypical morphology in the sub-maxillary gland2009 •
Journal of Volcanology and Geothermal Research
Spatio-temporal surface temperature variations detected by satellite thermal infrared images at Merapi volcano, Indonesia2021 •
Revista Brasileira de Sementes
Utilização do teste de raios-X na avaliação da qualidade de sementes de canafístula (Peltophorum dubium (Sprengel) Taubert2003 •
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Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor2009 •
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Integrated Reporting and Protection of Non-Financial Stakeholders in Nigerian Deposit Money Banks2022 •
Proceedings of the Nutrition Society
Validation of a food frequency questionnaire specific for salt intake in Saudi Arabian adults using urinary biomarker and repeated multiple pass 24-hour dietary recall2015 •
The Journal of Physical Chemistry
Study of the kinetics of hydrogen absorption and desorption through simulation methods: the case of magnesium hydride1991 •
Zenodo (CERN European Organization for Nuclear Research)
A Study on Optimum Portfolio Using Abnormal Return With Special Reference to Nifty2019 •
Jurnal Spektrum Komunikasi
NHS International Hospital Branding Image Strategy Through Integrated Marketing Communication2021 •