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Using in vitro data to derive acceptable exposure levels: A case study on PBDE developmental neurotoxicity
ScienceDirect.com
Current acceptable chemical exposure levels (e.g., tolerable daily intake) are mainly based on animal experiments, which are costly, time-consuming,...
10 months ago
A 21st century approach to protect children’s brains from environmental hazards
Wiley Analytical Science
Neurodevelopment involves several interrelated processes that are particularly vulnerable to chemical exposure. Exposure of the developing...
7 months ago
A Brainer on Neurotoxicity
Frontiers
A Brainer on Neurotoxicity \nEllen Fritsche, Ellen Fritsche 1,2 * Helena Therese Hogberg Helena Therese Hogberg 3 * 1 IUF-Leibniz Research Institute for...
52 months ago
BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action
Nature
Polybrominated diphenyl ethers (PBDEs) are bioaccumulating flame retardants causing developmental neurotoxicity (DNT) in humans and rodents.
91 months ago
(PDF) A Brainer on Neurotoxicity
ResearchGate
PDF | On Jun 30, 2020, Ellen Fritsche and others published A Brainer on Neurotoxicity | Find, read and cite all the research you need on...
52 months ago
Caenorhabditis elegans Neurotoxicity Testing: Novel Applications in the Adverse Outcome Pathway Framework
Frontiers
Neurological hazard assessment of industrial and pesticidal chemicals demands a substantial amount of time and resources. Caenorhabditis elegans is an...
4 months ago
The development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H
Nature
Here we present an alternative in vitro CSC model based on the oncogenic transformation of single clone-derived human induced pluripotent stem cells (hiPSC).
10 months ago
David Fike Obituary (2017) - Miami, FL - the Miami Herald
Legacy.com
David Floyd Fike, PhD, formerly of Miami, beloved husband of Ellen Fritsche Fike, died peacefully at home in Longwood, FL on December 19, 2017.
82 months ago
The drug-development process. Taking anywhere up to 15 years and a cost...
ResearchGate
Download scientific diagram | The drug-development process. Taking anywhere up to 15 years and a cost of ∼$1.7 billion, the process can be separated into...
5 months ago
Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake
Nature
Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient...
68 months ago