WO2014159824A4 - External bone fixation device - Google Patents

External bone fixation device Download PDF

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Publication number
WO2014159824A4
WO2014159824A4 PCT/US2014/025263 US2014025263W WO2014159824A4 WO 2014159824 A4 WO2014159824 A4 WO 2014159824A4 US 2014025263 W US2014025263 W US 2014025263W WO 2014159824 A4 WO2014159824 A4 WO 2014159824A4
Authority
WO
WIPO (PCT)
Prior art keywords
strut
sleeve
threaded rod
axis
actuator
Prior art date
Application number
PCT/US2014/025263
Other languages
French (fr)
Other versions
WO2014159824A3 (en
WO2014159824A2 (en
Inventor
Jean-Noel Bordeaux
Michael Wahl
Thomas Maughan
Nicole MURRY
Original Assignee
DePuy Synthes Products, LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/800,545 external-priority patent/US8864763B2/en
Priority claimed from US13/800,319 external-priority patent/US9039706B2/en
Priority to EP14721066.0A priority Critical patent/EP2967669B1/en
Priority to JP2016501803A priority patent/JP6382293B2/en
Priority to CN201480014050.3A priority patent/CN105050517B/en
Priority to KR1020157028671A priority patent/KR102348369B1/en
Priority to BR112015022354-0A priority patent/BR112015022354B1/en
Priority to CA2905865A priority patent/CA2905865C/en
Application filed by DePuy Synthes Products, LLC filed Critical DePuy Synthes Products, LLC
Priority to RU2015143523A priority patent/RU2015143523A/en
Priority to US14/774,374 priority patent/US9675382B2/en
Priority to EP17184793.2A priority patent/EP3281592B1/en
Priority to ES14721066.0T priority patent/ES2649161T3/en
Publication of WO2014159824A2 publication Critical patent/WO2014159824A2/en
Publication of WO2014159824A3 publication Critical patent/WO2014159824A3/en
Publication of WO2014159824A4 publication Critical patent/WO2014159824A4/en
Priority to US15/590,687 priority patent/US10470800B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B17/62—Ring frames, i.e. devices extending around the bones to be positioned
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B17/64—Devices extending alongside the bones to be positioned
    • A61B17/6416—Devices extending alongside the bones to be positioned with non-continuous, e.g. hinged, pin-clamp connecting element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B17/64—Devices extending alongside the bones to be positioned
    • A61B17/6466—Devices extending alongside the bones to be positioned with pin-clamps movable along a solid connecting rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B17/66—Alignment, compression or distraction mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B17/64—Devices extending alongside the bones to be positioned
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B17/64—Devices extending alongside the bones to be positioned
    • A61B17/6441—Bilateral fixators, i.e. with both ends of pins or wires clamped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B2017/606—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors with resilient spring element

Abstract

The present application discloses embodiments related to an external bone fixation device configured to correct bone deformities or repair bone injuries. The device can include a plurality of bases configured to be attached to portions of a bone and a plurality of struts configured to be adjustable in length to change the position and orientation of the plurality of bases and the attached bone portions.

Claims

1 AMENDED CLAIMS received by the International Bureau on 30 December 2014 (30.12.2014)
1. A strut configured to be connected to a pair of external bone fixation members along a strut axis, the strut comprising:
a strut body that includes a threaded rod and a sleeve, the threaded rod including a rod body that is elongate along the strut axis, the rod body defining an outer surface that is at least partially threaded, and the sleeve including a sleeve body and a sleeve bore that extends at least into the sleeve body, the sleeve bore configured to receive at least a portion of the threaded rod such that the threaded rod is translatable relative to the sleeve along the strut axis; and
an actuator supported by the strut body and threadedly attached to the threaded rod, such that rotation of the actuator relative to the threaded rod about the strut axis translates at least one or both of the threaded rod and the sleeve relative to the other of the threaded rod and the sleeve along the strut axis, the actuator including a gripping member that is configured to receive a torque that rotates the actuator relative to the threaded rod about the strut axis;
wherein the gripping member includes a body and a gripping member bore that extends through the body of the gripping member, the body of the gripping member having an inner surface that at least partially defines the gripping member bore and an outer surface opposite the inner surface, the gripping member bore is configured to at least partially receive the strut body, and the gripping member further includes a projection that extends out from the outer surface of the gripping member body in a direction away from the inner surface of the gripping member body.
2. The strut of claim 1, wherein the projection includes at least one side wall extending out from the outer surface of the gripping member body in the direction away from the inner surface of the gripping member body, the at least one side wall configured to receive the torque that rotates the actuator relative to the threaded rod about the strut axis.
3. The strut of claim 2, wherein the projection defines a height measured from a point where the at least one side wall extends out from the outer surface and in the direction that the at least one side wall extends away from the inner surface, the gripping member further includes an outer diameter defined by the outer surface, and the height is at least 10 percent of the outer diameter.
4. The strut of claim 3, wherein the height is at least 20 percent of the outer diameter. 2
5. The strut of any one of claims 1 to 4, wherein the actuator further includes a locking mechanism configured to prevent rotation of the actuator relative to the threaded rod.
6. The strut of claim 5, wherein the locking mechanism is rotatable about a pivot axis that is angularly offset with respect to the strut axis between a locked configuration and an unlocked configuration, such that when the locking mechanism is in the locked configuration, the locking mechanism prevents rotation of the actuator relative to the threaded rod about the strut axis, and when the locking mechanism is in the unlocked configuration the locking mechanism does not prevent rotation of the actuator relative to the threaded rod about the strut axis.
7. The strut of any one of claims 5 to 6, wherein the locking mechanism includes a lever and a biasing member, the biasing member configured to exert a biasing force on the lever such that the locking mechanism is biased toward the locked configuration.
8. The strut of claim 7, wherein the biasing force is exerted on the lever in a direction angularly offset with respect to the both the pivot axis and the strut axis.
9. The strut of any one of claims 5 to 8, wherein the projection pivotally supports the locking mechanism about the pivot axis.
10. The strut of any one of claims 1 to 9, wherein at least a portion of the actuator is made from a radiolucent material.
11. The strut of claim 10, wherein at least a portion of the actuator is made from at least one of PEEK, Ultem, Delrin, and Radel.
12. The strut of any one of claims 10 to 11, wherein at least a portion of the gripping member is made from at least one of PEEK, Ultem, Delrin, and Radel.
13. A strut configured to be connected to a pair of external bone fixation members along a strut axis, the strut comprising:
a strut body that includes a threaded rod and a sleeve, the threaded rod including a rod body that is elongate along the strut axis, the rod body defining an outer surface that is at least partially threaded, and the sleeve including a sleeve body and a bore that extends at least into the 3
sleeve body, the bore configured to receive at least a portion of the threaded rod such that the threaded rod is translatable relative to the sleeve along the strut axis; and
an actuator supported by the strut body and threadedly attached to the threaded rod, such that rotation of the actuator relative to the threaded rod about the strut axis translates at least one or both of the threaded rod and the sleeve relative to the other of the threaded rod and the sleeve along the strut axis,
a joint configured to attach to one of the pair of external bone fixation members, the joint including a first hinge body supported by the threaded rod, a second hinge body configured to attach to the one of the pair of external bone fixation members, and a cross coupling member configured to couple the first hinge body to the second hinge body such that the first hinge body is rotatable relative to the second hinge body about both a first axis that is angularly offset with respect to the strut axis, and a second axis that is angularly offset with respect to both the first axis and the strut axis,
wherein the cross coupling member is substantially spherical.
14. The strut of claim 13, wherein the joint is not translatable relative to the threaded rod along the strut axis.
15. The strut of any one of claims 13 to 14, wherein the joint is a first joint, and the strut further comprises:
a second joint configured to attach to the other of the pair of external bone fixation members, the second joint including a first hinge body supported by the sleeve, a second hinge body configured to attach to the other of the pair of external bone fixation members, and a cross coupling member configured to couple the first hinge body of the second joint to the second hinge body of the second joint such that the first hinge body of the second joint is rotatable relative to the second hinge body of the second joint about both a third axis that is angularly offset with respect to the strut axis, and a fourth axis that is angularly offset with respect to both the third axis and the strut axis,
wherein the cross coupling member of the second joint is substantially spherical.
16. The strut of any one of claims 13 to 14, wherein the first hinge body is not rotatable relative to the second hinge body about the strut axis. 4
17. The strut of any one of claims 13 to 14 and 16, wherein the cross coupling member is made from a more radiopaque material than the first and second hinge bodies.
18. The strut of claim 17, wherein the cross coupling member is made from titanium and the first and second hinge bodies are made from aluminum.
19. The strut of any one claims 13 to 14 and 16 to 18, wherein the cross coupling member is radiopaque.
20. A strut configured to be connected to a pair of external bone fixation members along a strut axis, the strut comprising:
a threaded rod including a rod body that is elongate along the strut axis, the rod body defining an outer surface that is at least partially threaded,
a sleeve including a sleeve body, the sleeve body defining an inner surface that defines a bore that extends at least into the sleeve body and is configured to receive a portion of the rod body,
an actuator threadedly attached to the threaded rod and rotatably supported by the sleeve, wherein one of the inner surface and the rod body supports a track that is elongate along a direction parallel to the strut axis, and the other of the inner surface and the rod body fixedly supports a follower configured to ride along the track such that the threaded rod translates with respect to the sleeve along the strut axis when the actuator is rotated with respect to the sleeve and the threaded rod.
21. The strut of claim 20, wherein the track is a channel that extends into the inner surface of the sleeve.
22. The strut of any one of claims 20 to 21, wherein the follower is supported by the rod body.
23. The strut of any one of claims 21 to 22, wherein the channel does not extend through the rod body along a direction that is perpendicular to the strut axis. 5
24. The strut of any one of claims 20 to 23, wherein the sleeve body includes an outer surface opposite the inner surface, and the sleeve defines a slot that extends through the sleeve body from the inner surface to the outer surface.
25. The strut of any one of claims 20 to 24, further comprising a length indicator translatably locked relative to the threaded rod, wherein the sleeve includes markings on the outer surface of the sleeve body, such that a relative position between the length indicator and the marking provides an indication of a length of the strut.
26. The strut of any one of claims 20 to 25, wherein engagement of the follower and the track prevents relative rotation between the sleeve and the threaded rod as the actuator rotates about the sleeve to cause the threaded rod to translate in the bore of the sleeve body.
27. A method of assembling an external bone fixation device configured to repair a deformity in a bone, the external bone fixation device including first and second external bone fixation members, and a strut that has a first joint configured to be attached to the first external bone fixation member, and a second joint spaced from the first joint along a strut axis, the second joint configured to be attached to the second external bone fixation member, the method comprising the steps of:
positioning the strut relative to the first external bone fixation member such that a first fastener receiving hole of the first joint is aligned with a second fastener receiving hole of the first external bone fixation member;
inserting a first fastener at least into the first fastener receiving hole and the second fastener receiving hole so as to attach the first joint to the first external bone fixation member;
rotating the strut relative to the first external bone fixation member about the strut axis to a predetermined orientation;
aligning a third fastener receiving hole of a second joint of the strut with a fourth fastener receiving hole of the second external bone fixation member; and
inserting a second fastener at least into the third fastener receiving hole and the fourth fastener receiving hole so as to attach the second joint to the second external bone fixation member, such that each of the first and second joints is rotatably fixed with respect to both of the first and second external bone fixation members about the strut axis. 6
28. The method of claim 27, wherein the rotating step comprises locating an actuator of the strut such that depression of a locking mechanism body carried by the actuator along a direction having a vector toward the bone actuates the strut from a locked configuration whereby the locking mechanism body prevents the actuator from rotating relative to a threaded rod of the strut along a direction of rotation about the strut axis, to an unlocked position whereby the locking mechanism body does not prevent the actuator from rotating relative to the threaded rod along the direction of rotation about the strut axis.
29. The method of claim 27, wherein the rotating step comprises positioning a length indicator in substantially the predetermined orientation, the length indicator configured to display a length of the strut.
30. The method of any one of claims 27 to 29, wherein the step of inserting a first fastener comprises inserting the first fastener through the second fastener receiving hole and into the first fastener receiving hole.
31. The method of any one of claims 27 to 30, wherein the step of inserting a second fastener comprises inserting the second fastener through the fourth fastener receiving hole and into the third fastener receiving hole.
32. A strut configured to be connected to a pair of external bone fixation members along a strut axis, the strut comprising:
a threaded rod including a rod body that is elongate along the strut axis, the rod body defining an outer surface that is at least partially threaded, the outer surface defining a cross- sectional shape with respect to a direction parallel to the strut axis, the cross-sectional shape being non-circular;
a sleeve including a sleeve body and a bore that extends at least into the sleeve body, the sleeve body defining an inner surface that defines the bore, the inner surface defining at opening of the bore, the opening defining a cross-sectional shape with respect to the direction, the cross- sectional shape of the opening corresponding to the cross-sectional shape of the outer surface such that the opening is configured to receive a portion of the rod body and prevent the threaded rod from rotating relative to the sleeve; and
an actuator threadedly attached to the threaded rod and rotatably supported by the sleeve; 7
wherein when the portion of the rod body is inserted into the opening of the threaded rod, actuation of the actuator causes at least one or both of the threaded rod and the sleeve to translate relative to the other of the threaded rod and the sleeve along the strut axis.
33. The strut of claim 32, wherein actuation of the actuator includes rotation of the actuator relative to the threaded rod about the strut axis.
34. The strut of any one of claims 32 to 33, wherein the cross-sectional shape of the outer surface matches the cross-sectional shape of the opening.
35. The strut of any one of claims 32 to 34, wherein the threaded rod includes at least one flat that partially defines the cross-sectional shape of the outer surface.
36. The strut of claim 35, wherein the at least one flat extends along a plane that is partially defined by a chord of a circular shape, a portion of the circular shape defining the outer surface.
37. The strut of claim 36, wherein the plane is further defined by a direction that is parallel to the strut axis.
38. The strut of any one of claims 32 to 37, wherein the inner surface includes at least one flat that partially defines the cross-sectional shape of the opening.
39. The strut of any one of claims 32 to 38, wherein the cross-sectional shape of the outer surface and the cross-sectional shape of the opening are each substantially D-shaped.
40. The strut of any one of claims 32 to 39, further comprising a length measurement device that is configured attached to the strut and determine the length of the strut.
41. The strut of claim 40, wherein the length measurement device includes a sensor and a marker, the sensor and the marker configured to be secured to strut such that rotation of the actuator causes at least one or both of the sensor and the marker to translate relative to the other of the sensor and the marker along the strut axis.
42. The strut of claim 41, wherein the sensor is supported by the sleeve and the marker is supported by the threaded rod.
8
43. The strut of any one of claims 40 to 42, wherein the length measurement device outputs the length of the strut to a digital display supported by the length measurement device.
44. The strut of any one of claims 40 to 43, wherein the length measurement device transmits the length of the strut wirelessly to a digital display on a device separate from the length measurement device.
PCT/US2014/025263 2013-03-13 2014-03-13 External bone fixation device WO2014159824A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP17184793.2A EP3281592B1 (en) 2013-03-13 2014-03-13 External bone fixation device
ES14721066.0T ES2649161T3 (en) 2013-03-13 2014-03-13 External bone fixation device
RU2015143523A RU2015143523A (en) 2013-03-13 2014-03-13 DEVICE FOR EXTERNAL BONE FIXING
CN201480014050.3A CN105050517B (en) 2013-03-13 2014-03-13 External bone fixation devices
KR1020157028671A KR102348369B1 (en) 2013-03-13 2014-03-13 External bone fixation device
BR112015022354-0A BR112015022354B1 (en) 2013-03-13 2014-03-13 Anchor configured to be connected to a pair of external bone anchors
CA2905865A CA2905865C (en) 2013-03-13 2014-03-13 External bone fixation device
EP14721066.0A EP2967669B1 (en) 2013-03-13 2014-03-13 External bone fixation device
JP2016501803A JP6382293B2 (en) 2013-03-13 2014-03-13 External bone fixation device
US14/774,374 US9675382B2 (en) 2013-03-13 2014-03-13 External bone fixation device
US15/590,687 US10470800B2 (en) 2013-03-13 2017-05-09 External bone fixation device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13/800,545 US8864763B2 (en) 2013-03-13 2013-03-13 External bone fixation device
US13/800,319 US9039706B2 (en) 2013-03-13 2013-03-13 External bone fixation device
US13/800,319 2013-03-13
US13/800,545 2013-03-13

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US13/800,545 Continuation US8864763B2 (en) 2013-03-13 2013-03-13 External bone fixation device
US13/800,545 Continuation-In-Part US8864763B2 (en) 2013-03-13 2013-03-13 External bone fixation device

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/774,374 A-371-Of-International US9675382B2 (en) 2013-03-13 2014-03-13 External bone fixation device
US15/590,687 Continuation US10470800B2 (en) 2013-03-13 2017-05-09 External bone fixation device

Publications (3)

Publication Number Publication Date
WO2014159824A2 WO2014159824A2 (en) 2014-10-02
WO2014159824A3 WO2014159824A3 (en) 2014-12-31
WO2014159824A4 true WO2014159824A4 (en) 2015-02-19

Family

ID=50631010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/025263 WO2014159824A2 (en) 2013-03-13 2014-03-13 External bone fixation device

Country Status (10)

Country Link
US (2) US9675382B2 (en)
EP (2) EP3281592B1 (en)
JP (1) JP6382293B2 (en)
KR (1) KR102348369B1 (en)
CN (1) CN105050517B (en)
BR (1) BR112015022354B1 (en)
CA (1) CA2905865C (en)
ES (1) ES2649161T3 (en)
RU (1) RU2015143523A (en)
WO (1) WO2014159824A2 (en)

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JP2016515868A (en) 2016-06-02
EP3281592A1 (en) 2018-02-14
EP2967669B1 (en) 2017-09-13
BR112015022354A2 (en) 2017-07-18
WO2014159824A3 (en) 2014-12-31
JP6382293B2 (en) 2018-08-29
EP3281592B1 (en) 2021-04-21
CN105050517B (en) 2019-01-01
CA2905865A1 (en) 2014-10-02
US20170238967A1 (en) 2017-08-24
WO2014159824A2 (en) 2014-10-02
BR112015022354B1 (en) 2022-05-03
US9675382B2 (en) 2017-06-13
KR102348369B1 (en) 2022-01-10
US10470800B2 (en) 2019-11-12
RU2015143523A (en) 2017-04-19
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KR20150129812A (en) 2015-11-20
US20160022314A1 (en) 2016-01-28
CA2905865C (en) 2021-03-02
CN105050517A (en) 2015-11-11

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