WO2011070592A3 - Novel sugar derivatives as sglt2 inhibitors - Google Patents
Novel sugar derivatives as sglt2 inhibitors Download PDFInfo
- Publication number
- WO2011070592A3 WO2011070592A3 PCT/IN2010/000796 IN2010000796W WO2011070592A3 WO 2011070592 A3 WO2011070592 A3 WO 2011070592A3 IN 2010000796 W IN2010000796 W IN 2010000796W WO 2011070592 A3 WO2011070592 A3 WO 2011070592A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- polymorphs
- prodrugs
- solvates
- metabolites
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Abstract
The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2). The invention also relates to the use of compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof, for the manufacture of a medicament for the prophylaxis, amelioration and/or treatment of conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2) and the related diseases, disorders and conditions, in a subject in need thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2553DE2009 | 2009-12-09 | ||
IN2553/DEL/2009 | 2009-12-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011070592A2 WO2011070592A2 (en) | 2011-06-16 |
WO2011070592A3 true WO2011070592A3 (en) | 2012-05-10 |
Family
ID=44145994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2010/000796 WO2011070592A2 (en) | 2009-12-09 | 2010-12-09 | Novel sugar derivatives |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR079438A1 (en) |
WO (1) | WO2011070592A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013038429A2 (en) | 2011-09-13 | 2013-03-21 | Panacea Biotec Ltd. | Novel sglt inhibitors |
WO2013090550A1 (en) | 2011-12-15 | 2013-06-20 | National Health Research Institutes | Novel glycoside compounds |
JP6058023B2 (en) | 2011-12-15 | 2017-01-11 | ファイザー・リミテッドPfizer Limited | Sulfonamide derivatives |
CA2891773C (en) * | 2012-11-20 | 2021-01-19 | Lexicon Pharmaceuticals, Inc. | Inhibitors of sodium glucose cotransporter 1 |
EP4006017A4 (en) * | 2019-07-26 | 2023-09-06 | Medshine Discovery Inc. | Sglt2/dpp4 inhibitor and application thereof |
WO2022160737A1 (en) * | 2021-01-26 | 2022-08-04 | 东宝紫星(杭州)生物医药有限公司 | Crystal form of tetrahydropyran ring compound and preparation method therefor |
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WO2009026537A1 (en) * | 2007-08-23 | 2009-02-26 | Theracos, Inc. | Benzylbenzene derivatives and methods of use |
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US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US6555519B2 (en) | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
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-
2010
- 2010-12-09 WO PCT/IN2010/000796 patent/WO2011070592A2/en active Application Filing
- 2010-12-09 AR ARP100104559A patent/AR079438A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001027128A1 (en) * | 1999-10-12 | 2001-04-19 | Bristol-Myers Squibb Company | C-aryl glucoside sglt2 inhibitors |
WO2009026537A1 (en) * | 2007-08-23 | 2009-02-26 | Theracos, Inc. | Benzylbenzene derivatives and methods of use |
Also Published As
Publication number | Publication date |
---|---|
AR079438A1 (en) | 2012-01-25 |
WO2011070592A2 (en) | 2011-06-16 |
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