WO2007149504A3 - Isoalpha acid based protein kinase modulation cancer treatment - Google Patents
Isoalpha acid based protein kinase modulation cancer treatment Download PDFInfo
- Publication number
- WO2007149504A3 WO2007149504A3 PCT/US2007/014413 US2007014413W WO2007149504A3 WO 2007149504 A3 WO2007149504 A3 WO 2007149504A3 US 2007014413 W US2007014413 W US 2007014413W WO 2007149504 A3 WO2007149504 A3 WO 2007149504A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein kinase
- cancer treatment
- acid based
- based protein
- kinase modulation
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on isoalpha acids, commonly found in hops.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81506406P | 2006-06-20 | 2006-06-20 | |
US60/815,064 | 2006-06-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007149504A2 WO2007149504A2 (en) | 2007-12-27 |
WO2007149504A3 true WO2007149504A3 (en) | 2008-03-06 |
Family
ID=38833737
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/014413 WO2007149504A2 (en) | 2006-06-20 | 2007-06-20 | Isoalpha acid based protein kinase modulation cancer treatment |
PCT/US2007/014374 WO2007149482A2 (en) | 2006-06-20 | 2007-06-20 | Xanthohumol based protein kinase modulation cancer treatment |
PCT/US2007/014380 WO2007149485A1 (en) | 2006-06-20 | 2007-06-20 | Acacia based protein kinase modulation cancer treatment |
PCT/US2007/014372 WO2007149480A2 (en) | 2006-06-20 | 2007-06-20 | Reduced isoalpha acid based protein kinase modulation cancer treatment |
PCT/US2007/014412 WO2007149503A2 (en) | 2006-06-20 | 2007-06-20 | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
PCT/US2007/014373 WO2007149481A2 (en) | 2006-06-20 | 2007-06-20 | Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
PCT/US2007/014414 WO2007149505A2 (en) | 2006-06-20 | 2007-06-20 | Beta acid based protein kinase modulation cancer treatment |
PCT/US2007/014450 WO2007149523A2 (en) | 2006-06-20 | 2007-06-20 | Hexahydro-isoalpha acid based protein kinase modulation cancer treatment |
Family Applications After (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/014374 WO2007149482A2 (en) | 2006-06-20 | 2007-06-20 | Xanthohumol based protein kinase modulation cancer treatment |
PCT/US2007/014380 WO2007149485A1 (en) | 2006-06-20 | 2007-06-20 | Acacia based protein kinase modulation cancer treatment |
PCT/US2007/014372 WO2007149480A2 (en) | 2006-06-20 | 2007-06-20 | Reduced isoalpha acid based protein kinase modulation cancer treatment |
PCT/US2007/014412 WO2007149503A2 (en) | 2006-06-20 | 2007-06-20 | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
PCT/US2007/014373 WO2007149481A2 (en) | 2006-06-20 | 2007-06-20 | Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
PCT/US2007/014414 WO2007149505A2 (en) | 2006-06-20 | 2007-06-20 | Beta acid based protein kinase modulation cancer treatment |
PCT/US2007/014450 WO2007149523A2 (en) | 2006-06-20 | 2007-06-20 | Hexahydro-isoalpha acid based protein kinase modulation cancer treatment |
Country Status (9)
Country | Link |
---|---|
US (6) | US20080033057A1 (en) |
EP (4) | EP2046353A4 (en) |
JP (4) | JP2009541326A (en) |
KR (4) | KR20090023721A (en) |
CN (4) | CN101573128A (en) |
AU (4) | AU2007261400A1 (en) |
CA (4) | CA2655059A1 (en) |
TW (8) | TW200817027A (en) |
WO (8) | WO2007149504A2 (en) |
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US7736677B2 (en) * | 2001-06-20 | 2010-06-15 | Metaproteomics, Llc | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
EP2046353A4 (en) * | 2006-06-20 | 2010-01-27 | Metaproteomics Llc | Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
US20080051466A1 (en) * | 2006-06-20 | 2008-02-28 | Metaproteomics, Llc | Isoalpha acid based protein kinase modulation cancer treatment |
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US10918650B2 (en) * | 2016-06-02 | 2021-02-16 | University Of South Florida | Method of treating melanoma using an inhibitor of an atypical protein kinase C |
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CN107115328B (en) * | 2017-05-24 | 2019-08-30 | 中美(河南)荷美尔肿瘤研究院 | Application of the xanthohumol in terms of preparing protein kinase B inhibitor |
CN108535480B (en) * | 2018-03-05 | 2020-03-06 | 南通大学附属医院 | Application of EphA8 gene in preparation of anti-breast cancer drug and diagnostic kit thereof |
CN108586226B (en) * | 2018-05-31 | 2021-06-18 | 温州医科大学 | 3-methyl-3-butene-2-alcohol chalcone compound and synthesis and application thereof |
CN110833550B (en) * | 2018-08-15 | 2023-03-24 | 广西梧州制药(集团)股份有限公司 | Application of pyrazolopyrimidine derivative in treatment of liver injury caused by acute pancreatitis |
CN114921546B (en) * | 2022-05-13 | 2023-02-21 | 核工业总医院 | Application of circHIPK2 as breast cancer biomarker |
CN116102416A (en) * | 2023-02-21 | 2023-05-12 | 蚌埠医学院 | Bavachin derivatives, preparation method thereof and application thereof in preparation of anticancer drugs |
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- 2007-06-20 WO PCT/US2007/014412 patent/WO2007149503A2/en active Application Filing
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