WO2005063785A3 - Glucopyranosyloxy-substituted aromates, medicaments containing said compounds, the use thereof, and methods for producing the same - Google Patents

Glucopyranosyloxy-substituted aromates, medicaments containing said compounds, the use thereof, and methods for producing the same Download PDF

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Publication number
WO2005063785A3
WO2005063785A3 PCT/EP2004/014319 EP2004014319W WO2005063785A3 WO 2005063785 A3 WO2005063785 A3 WO 2005063785A3 EP 2004014319 W EP2004014319 W EP 2004014319W WO 2005063785 A3 WO2005063785 A3 WO 2005063785A3
Authority
WO
WIPO (PCT)
Prior art keywords
glucopyranosyloxy
compounds
aromates
producing
methods
Prior art date
Application number
PCT/EP2004/014319
Other languages
German (de)
French (fr)
Other versions
WO2005063785A2 (en
Inventor
Frank Himmelsbach
Peter Eickelmann
Edward Leon Barsoumian
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Frank Himmelsbach
Peter Eickelmann
Edward Leon Barsoumian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Frank Himmelsbach, Peter Eickelmann, Edward Leon Barsoumian filed Critical Boehringer Ingelheim Int
Priority to CA002548353A priority Critical patent/CA2548353A1/en
Priority to JP2006546000A priority patent/JP2007515441A/en
Priority to EP04803932A priority patent/EP1699807A2/en
Publication of WO2005063785A2 publication Critical patent/WO2005063785A2/en
Publication of WO2005063785A3 publication Critical patent/WO2005063785A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

The invention relates to glucopyranosyloxy-substituted aromates of general formula (I), wherein R1 to R6 and R7a, R7b, R7c are defined according to patent claim 1. The invention also relates to the tautomers, stereoisomers, mixtures and salts of said aromates, especially the physiologically compatible salts comprising inorganic or organic acids and having valuable pharmacological properties, especially an inhibiting effect on the sodium-dependent glucose cotransporter SGLT2. The invention further relates to the treatment of diseases, especially metabolic diseases such as diabetes, and to the production of said compounds.
PCT/EP2004/014319 2003-12-22 2004-12-16 Glucopyranosyloxy-substituted aromates, medicaments containing said compounds, the use thereof, and methods for producing the same WO2005063785A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002548353A CA2548353A1 (en) 2003-12-22 2004-12-16 Glucopyranosyloxy-substituted aromates, medicaments containing said compounds, the use thereof, and methods for producing the same
JP2006546000A JP2007515441A (en) 2003-12-22 2004-12-16 Glucopyranosyloxy substituted aromatic compounds, medicaments containing said compounds, their use and methods for their production
EP04803932A EP1699807A2 (en) 2003-12-22 2004-12-16 Glucopyranosyloxy-substituted aromates, medicaments containing said compounds, the use thereof, and methods for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10361133.9 2003-12-22
DE10361133A DE10361133A1 (en) 2003-12-22 2003-12-22 Glucopyranosyloxy-substituted aromatics, medicaments containing these compounds, their use and processes for their preparation

Publications (2)

Publication Number Publication Date
WO2005063785A2 WO2005063785A2 (en) 2005-07-14
WO2005063785A3 true WO2005063785A3 (en) 2006-04-13

Family

ID=34683870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/014319 WO2005063785A2 (en) 2003-12-22 2004-12-16 Glucopyranosyloxy-substituted aromates, medicaments containing said compounds, the use thereof, and methods for producing the same

Country Status (5)

Country Link
EP (1) EP1699807A2 (en)
JP (1) JP2007515441A (en)
CA (1) CA2548353A1 (en)
DE (1) DE10361133A1 (en)
WO (1) WO2005063785A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
US9464043B2 (en) 2013-10-12 2016-10-11 Theracos Sub, Llc Preparation of hydroxy-benzylbenzene derivatives

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200637869A (en) 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
ES2346347T3 (en) * 2005-07-27 2010-10-14 Boehringer Ingelheim International Gmbh DERIVATIVES OF ((HETERO) CICLOALQUILETINIL-BENCIL) -BENZENE AND ITS USE AS INHIBITORS OF THE SODIUM DEPENDENT GLUCOSE COTRANSPORTADOR (SGLT).
PE20080697A1 (en) 2006-05-03 2008-08-05 Boehringer Ingelheim Int BENZONITRILE DERIVATIVES SUBSTITUTED WITH GLUCOPYRANOSIL, PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS OF THIS TYPE, THEIR USE AND PROCEDURE FOR THEIR MANUFACTURE
PE20080251A1 (en) 2006-05-04 2008-04-25 Boehringer Ingelheim Int USES OF DPP IV INHIBITORS
PE20090938A1 (en) 2007-08-16 2009-08-08 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITION INCLUDING A BENZENE DERIVATIVE SUBSTITUTED WITH GLUCOPYRANOSIL
BRPI0815708B8 (en) 2007-08-23 2021-05-25 Theracos Sub Llc compound, prodrug ester, pharmaceutical composition, and, method of treating a disease or condition
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
WO2009096503A1 (en) * 2008-01-31 2009-08-06 Daiichi Sankyo Company, Limited Benzyl phenyl glucopyranoside derivative
US9061060B2 (en) 2008-07-15 2015-06-23 Theracos Inc. Deuterated benzylbenzene derivatives and methods of use
WO2010022313A2 (en) 2008-08-22 2010-02-25 Theracos, Inc. Processes for the preparation of sglt2 inhibitors
MX339194B (en) 2009-02-13 2016-05-16 Boehringer Ingelheim Int Pharmaceutical composition comprising a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof.
MX2012002942A (en) 2009-09-30 2012-04-11 Boehringer Ingelheim Int Method for the preparation of a crystalline form of 1-chloro-4- (beta-d-glucopyranos-1-yl)-2-(4-((s)-tetrahydrofuran-3-yloxy)be nzyl)benzene.
EP2486029B1 (en) 2009-09-30 2015-06-10 Boehringer Ingelheim International GmbH Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
UY32919A (en) 2009-10-02 2011-04-29 Boehringer Ingelheim Int Pharmaceutical composition, pharmaceutical dosage form, procedure for its preparation, methods for its treatment and its uses
WO2011153712A1 (en) 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
AR085689A1 (en) 2011-03-07 2013-10-23 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITIONS OF METFORMIN, LINAGLIPTINE AND AN SGLT-2 INHIBITOR
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US9192617B2 (en) 2012-03-20 2015-11-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
PT2981271T (en) 2013-04-05 2019-02-19 Boehringer Ingelheim Int Therapeutic uses of empagliflozin
US20140303097A1 (en) 2013-04-05 2014-10-09 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
PL2986304T3 (en) 2013-04-18 2022-05-02 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
CN114933619B (en) * 2022-05-18 2024-03-01 上海科利生物医药有限公司 Thioglycoside column-like analogues and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074834A1 (en) * 2000-03-30 2001-10-11 Bristol-Myers Squibb Company O-aryl glucoside sglt2 inhibitors and method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003011880A1 (en) * 2001-07-31 2003-02-13 Kissei Pharmaceutical Co., Ltd. Glucopyrano syloxybenzyl benzene derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074834A1 (en) * 2000-03-30 2001-10-11 Bristol-Myers Squibb Company O-aryl glucoside sglt2 inhibitors and method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
US9464043B2 (en) 2013-10-12 2016-10-11 Theracos Sub, Llc Preparation of hydroxy-benzylbenzene derivatives

Also Published As

Publication number Publication date
DE10361133A1 (en) 2005-07-21
CA2548353A1 (en) 2005-07-14
WO2005063785A2 (en) 2005-07-14
EP1699807A2 (en) 2006-09-13
JP2007515441A (en) 2007-06-14

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