US8012930B2 - Methods of treating pervasive development disorders - Google Patents
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- US8012930B2 US8012930B2 US12/046,402 US4640208A US8012930B2 US 8012930 B2 US8012930 B2 US 8012930B2 US 4640208 A US4640208 A US 4640208A US 8012930 B2 US8012930 B2 US 8012930B2
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1118—Determining activity level
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- A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Definitions
- the present invention relates generally to a method for treating individuals diagnosed with a form of PDD (pervasive development disorder) and other disorders such as ADD (attention deficit disorder) and ADHD (attention deficit hyperactivity disorder). More specifically, the present invention is directed to therapeutic method for treating individuals with such disorders by administering secretin, other neuropeptides, peptides, and/or digestive enzymes, as well as a prognosticative method for determining the potential effectiveness of the administration of secretin, other neuropeptides, peptides, and/or digestive enzymes for the treatment of such disorders.
- PDD pervasive development disorder
- ADD attention deficit disorder
- ADHD attention deficit hyperactivity disorder
- PDDs are a class of disorders defined by both American and International diagnostic systems (Le, the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) and World Health Organization: International Classification of Diseases, Tenth revision (ICD-10)).
- the spectrum of PDDs include disorders such as Autism, Aspergers, ADD, and ADHD.
- PDDs are typically characterized by multiple distortions in the development of basic psychological functions that are involved in the development of social skills and language, such as attention, perception reality testing and motor movement.
- many children diagnosed with autism for example, suffer from primary diffuse gastrointestinal problems such as protracted diarrhea and constipation.
- PDDs are currently of unknown etiology
- many conventional methods such as dietary alteration, behavioral modification, and medication, have been utilized for treating individuals suffering from PDD related disorders.
- PDD related disorders have no known treatment beyond that which is symptomatic, and these conventional methods have proven unsuccessful in allowing such children and adults to become symptom, or disorder free.
- a child which displays signs of developmentally inappropriate inattention, impulsivity and hyperactivity is typically diagnosed as having ADD and/or ADHD. With these disorders, there can be marked disturbances of organization, distractibility, impulsivity, restlessness, and other disturbances of language and/or social behavior.
- a combination of psychiatric care and medicine is typically used for treating children with ADD and ADHD.
- the present invention is directed to a method of analyzing the chymotrypsin level of an individual to determine the potential benefit of the administration of secretin, other neuropeptides, peptides and/or digestive enzyme administration to such individual, and in particular, as a prognosticative of potential secretin, other neuropeptides, peptides, and/or digestive enzyme administration for individuals diagnosed as having ADD, ADHD, Autism and other PDD related disorders.
- a method for determining the efficacy of secretin, other neuropeptides, peptides, or digestive enzymes for the treatment of an individual diagnosed with a pervasive developmental disorder (PDD) comprises obtaining a sample of feces from an individual, determining a quantitative level of chymotrypsin present in the sample, and correlating the quantitative level of chymotrypsin determined to be present in the sample with the PDD to determine the efficacy of treating the individual with secretin, other neuropeptides, peptides, or digestive enzyme administration.
- PDD pervasive developmental disorder
- a therapeutic method for treating an individual diagnosed with a pervasive developmental disorder comprises determining the efficacy of the administration of secretin, other neuropeptides, peptides, and digestive enzyme for the treatment of the individual based on a measure of the individuals chymotrypsin level, and administering secretin, other neuropeptides, peptides, or digestive enzymes to the individual based on the determination of the measure of the individual's chymotrypsin level.
- the present invention involves determining the presence of abnormal protein digestion of individuals, especially children, by measuring the chymotrypsin levels so as to determine if the individual is likely to benefit from the administration of secretin, digestive enzymes, peptides and/or neuropeptides.
- fecal chymotrypsin level is a broad measure of protein and fat digestion, such levels can be applied to all those who may benefit from improvements in this mode of digestion.
- low measures of fecal chymotrypsin expresses an abnormality of protein digestion, it is postulated that an improvement of protein digestion to promote normal growth and development of an individual suffering from a PDD by the administration of secretin, other neuropeptides, peptides and/or digestive enzymes, can ameliorate the symptomatologies of PDDs.
- a therapeutic method for treating an individual diagnosed with a PDD including but not limited to Autism, Aspergers, ADD and ADHD, comprising the steps of:
- the therapeutic method involves administering a fecal chymotrypsin test to measure an individual's fecal chymotrypsin level.
- a fecal chymotrypsin test to measure an individual's fecal chymotrypsin level.
- an enzymatic spectrophotometry method is used for measuring the fecal chymotrypsin level of the individual.
- the individual is preferably administered 1 U/kg of body weight of porcine or human secretin by means of an intravenous push method. This method can be described as the administration of an IV push of saline solution and secretin to equal 1 U/kg of body weight.
- the individual receives 1 unit test dose (absolute).
- a period of one minute is allowed to pass to determine if the individual has any allergic reactions to the secretin. After one minute has elapsed, if no urticarial reaction or any other allergic reaction has occurred, the remainder of the dose is administered. Subsequent fecal chymotrypsin samples are then gathered at one week intervals post administration to determine any changes in the chymotrypsin levels.
- FIG. 1 illustrates the overall net change in results of a CARS test (Childhood Autism Rating Scale) depicting behavior of 16 autistic children pre-secretin and post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- CARS test Childhood Autism Rating Scale
- FIG. 2 illustrates percentage change from pre-secretin to postsecretin administration in the average scores of the respective components of the CARS test of FIG. 1 ;
- FIG. 3 illustrates the change in CARS scores for the sub-class Visual response from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 4 illustrates the change in CARS scores for the sub-class Verbal Skills from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 5 illustrates the change in CARS scores for the sub-class Touch/Taste/Smell from pre-secretin administration to three weeks postsecretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 6 illustrates the change in CARS scores for the sub-class Object Use from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 7 illustrates the change in CARS scores for the sub-class Listening from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 8 illustrates the change in CARS scores for the sub-class Imitation from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 9 illustrates the change in CARS scores for the sub-class Body Use from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 10 illustrates the change in CARS scores for the sub-class Adaptation to Change from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 11 illustrates the change in CARS scores for the sub-class Activity Level from pre-secretin administration to three weeks post-secretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 12 illustrates the change: in CARS scores for the sub-class General Impression from pre-secretin administration to three weeks postsecretin administration, where the solid lines indicate pre-secretin scores and the dotted lines indicate post-secretin scores;
- FIG. 13 illustrates the measured fecal chymotrypsin levels of 16 autistic children pre-secretin administration
- FIG. 14 illustrates the measured fecal chymotrypsin levels of the 16 autistic children approximately one week post-secretin administration
- FIG. 15 illustrates the measured fecal chymotrypsin levels of 28 ADD children
- FIG. 16 illustrates the measured fecal chymotrypsin levels of 34 ADHD children.
- FIG. 17 illustrates Ritalin levels administered before and after secretin administration in five of the ADHD children in FIG. 16 , where the shaded bars indication pre-secretin Ritalin levels and the non-shaded bars indicate post-secretin Ritalin levels,
- the present invention is directed to a method of analyzing chymotrypsin levels in persons, especially children, as a measure of the success of administering secretin, other neuropeptides, peptides and/or digestive enzymes for the therapeutic treatment of ADD, ADHD, Autism, Aspergers and other PDD related disorders.
- secretin for the treatment of Autism is presently in the investigational stages.
- research was conducted by the present inventor to formulate a process that would enable one to definitively determine if individuals, especially children, having a PDD could be tested prior to the administration of secretin for its possible efficacy for treating PDD.
- Fecal Chymotrypsin Test fecal Chymotrypsin Test
- the small intestine has a pH in the range of 1.0-1.5 when the bolus of food enters the small intestines.
- plasma concentrations of secretin increase when the duodenal pH is below 4.5, and typically doubles during the postprandial period.
- the s cells in the proximal portion of the small intestines release secretin in response to this low pH.
- the secretin is then released into the bloodstream and ultimately reaches the pancreas.
- the pancreas releases bicarbonate ions, water and electrolytes into the small intestines thus neutralizing the pH by bringing it from a 1.0-1.5 to approximately 6.5.
- pancreas secretes the enzyme trypsin in an inactive form, trypsinogen.
- the trypsinogen is converted to trypsin in the small intestines.
- the trypsin catalyzes the formation of chymotrypsinogen to chymotrypsin.
- These enzymes are essential for the digestion of protein.
- the amino acids necessary for the growth and development of individuals are absent. Therefore, based on tests performed by the present inventor, it is postulated that the increase of protein digestion of an individual suffering from PDD can lead to the improvement of such disorders. Accordingly, since secretin is responsible for aiding in the protein digestion process, it has been determined that the presence of abnormal protein digestion in individuals, especially children, is indicative of which individuals are likely to benefit from the administration of secretin.
- each of these levels were compared with threshold chymotrypsin levels to determine if the child was likely to benefit from secretin administration.
- threshold chymotrypsin levels By way of example, with the fecal chymotrypsin tests of the stool samples being performed at 30EC, normal levels of chymotrypsin are deemed to lie above 8.4 U/gram, whereas pathologically abnormal levels are deemed to lie below 4.2 U/gram.
- chymotrypsin levels between 8.4 U/gram and 4.2 U/gram are considered equivocal, and further testing of the individual's fecal chymotrypsin levels over a period of time should be performed. It is to be noted that as shown in FIG. 13 , all of the 16 autistic children that were tested had abnormal levels of fecal chymotrypsin presecretin administration.
- Another stool sample was then collected from each child two days after the first test and analyzed to determine the chymotrypsin levels. This second test is preferably performed to obtain additional chymotrypsin measurements to make a more accurate determination. Those children having abnormal levels of chymotrypsin in their stools are considered candidates for secretin administration. Other factors that may be considered in determining which children are potential candidates for secretin administration, aside from the fecal chymotrypsin levels, include a previously diagnosed history of autism, a history of gastrointestinal (GI) dysfunction, including any history of protracted diarrhea or constipation lasting for a weeks or months, as well as a self-limiting diet consisting primarily of carbohydrates.
- GI gastrointestinal
- the child Upon determining that a given child was likely to benefit from secretin administration based on the results of the fecal chymotrypsin test, the child was administered a CARS (Childhood Autism Rating Scale) test prior to being scheduled for secretin infusion.
- CARS Childhood Autism Rating Scale
- a preferred secretin infusion process was performed involving the administering of 1 U/kg of body weight of Secretin-Ferring for a period of nine months at intervals of approximately 6 weeks.
- another CARS test was administered to each of the 16 autistic children 3 weeks post secretin administration to determine if their autism had changed post infusion.
- a preferred secretin infusion process includes the initial step of prepping an arm of the candidate child with an IV injection of saline.
- a test dose of 1 U of Secretin-Ferring is then administered to the child.
- the child is examined for signs of allergic reaction including rash, increased heart rate, and increase of blood pressure. If the child does not display any signs of allergic reaction, the remaining units of Secretin-Ferring is administered to the child in the manner of an IV push, which is then followed by a saline flush. Subsequently, each child receives a 1 U/kg of body weight infusion of Secretin-Ferring approximately every 6 weeks for 9 months. It is to be understood that any commercially available form of secretin may be used.
- FIGS. 1-14 The results of Experiment 1 are illustrated in FIGS. 1-14 .
- the fecal chymotrypsin level of each of the 16 autistic children was measured again.
- the results of this test are illustrated in FIG. 14 .
- the chymotrypsin level of each of the 16 autistic children test increased post-secretin administration (as compared with the levels shown in FIG. 13 ).
- FIG. 1 illustrates the pre-secretin CARS test results (solid line) and the post-secretin CARS test results (dotted line) for each of the 16 autistic children tested approximately 3 weeks after the first secretin administration.
- FIG. 1 illustrates an overall decrease in the CARS scores indicating improvements in the PDD/autistic symptoms of the children.
- FIG. 2 illustrates respective percentage decreases in components of CARS scores, wherein the numbers represent percentage change in the average of the scores in each component of the CARS test post-secretin administration.
- FIGS. 3-12 illustrate the improved scores of each of the 16 autistic children for the individual components of the CARS scores. As shown, the component scores demonstrated improvement except for the fear component which increased 3 weeks post infusion.
- FIG. 15 illustrates the measured fecal chymotrypsin levels of these 28 children. It is to be noted that, as shown in FIG. 15 , all of the 28 ADD children were found to have sub-normal fecal chymotrypsin levels since all of the values fell below 8.4 U/g. More specifically, 8 out of 28 children were determined to have an equivocal fecal chymotrypsin level and 20 out of the 28 children were determined to have a pathologic level of fecal chymotrypsin. As noted above, a chymotrypsin level of 8.4 U/g is considered a reference value for normal levels of chymotrypsin.
- digestive enzymes comprising amylase, proteases, lipases, sucrase, maltase, and other digestive enzymes. These digestive enzymes were administered one tablet at each mealtime (i.e., three times a day), adjusted for the age and weight of the child. More specifically, for the ADD children ages 1-6, a quantity of digestive enzymes of approximately 4,000-8,000 U.S.P. Units/tablet comprising lipase, amylase and protease were administered. For the ADD children of ages 7-12, a quantity of digestive enzymes of approximately 8,000-12,000 U.S.P. Units/tablet comprising lipase, amylase and protease were administered. Other digestive enzymes that were administered in smaller quantities included cellulase, sucrase and maltase. These digestive enzymes were administered over a period of 6 months.
- the fecal chymotrypsin levels of 34 children diagnosed with ADHD were obtained using the fecal chymotrypsin test described above in Experiment 1, the levels of which are illustrated in FIG. 16 . As shown, 32 children out of 34 children tested were determined to have sub-normal fecal chymotrypsin levels. It is to be further noted that 24 of the 34 children were found to have pathologic levels of fecal chymotrypsin.
- FIG. 17 illustrates the required levels of Ritalin (methylphenidate) (in mg) of the 5 children tested both pre-secretin administration (as indicated by the shaded bars) and 6 months post-secretin administration (as indicated by the non-shaded bars). It is to be appreciated that as shown in FIG. 17 , each of the 5 children who were administered secretin demonstrated significant changes post-secretin administration with respect to the level of Ritalin (methylphenidate) (mg) that each child needed to re main at the same functional level as their functional level prior to secretin administration.
- the following experiment was performed to determine the effect of the administration of digestive enzymes to autistic children.
- the fecal chymotrypsin levels of 17 autistic children of varying ages were measured (pre-digestive enzyme administration) using the method described above in Experiment 1.
- the fecal chymotrypsin levels of these 17 children were measured 6 months post digestive enzyme administration after receiving digestive enzyme therapy as described below.
- the following table demonstrates the measured fecal chymotrypsin levels of these 17 children:
- each of the 17 autistic children were found to have either sub-normal or pathologic fecal chymotrypsin levels.
- the fecal chymotrypsin level of patient #9 was found to be sub-normal as it fell below 8.4 U/g and the fecal chymotrypsin levels of the remaining 16 children were found to be pathologic since the levels fell below 4.2 U/g.
- Each of the 17 autistic children were administered digestive/pancreatic enzymes comprising amylases, proteases, lipases, sucrases, maltases, and other diqestive/pancreatic enzymes including trypsin and chymotrypsin.
- the digestive enzymes were administered on a daily basis at each mealtime, preferably 3-6 times per day. The quantity of digestive enzymes were adjusted for the weight and ages of the child.
- a preferred quantity of lipases ranges from 4,000-20,000 U.S.P.
- a preferred quantity of proteases ranges from 10,000-50,000 U.S.P.
- a preferred quantity of amylases ranges from 10,000-60,000 U.S.P.
- a preferred quantity of pancreatin pancreatic extract
- a preferred quantity of chymotrypsin ranges from 2-5 mg
- a preferred quantity of trypsin ranges from 60-100 mg.
- any combination of two or more types of any of the above digestive enzymes may be administered.
- the measured fecal chymotrypsin levels of at least 16 of the 17 autistic children were found to increase 6 months post-digestive enzyme administration.
- the fecal chymotrypsin levels of 5 children (patients #4, 7, 8, 15, and 16) that were initially found to be pathologic had increased to the normal range 6 months post-digestive enzyme administration.
- Table 5 outlines the responses that were reported after administration of digestive enzymes to the autistic children in the range of ages 2-4 (i.e., 6 of the 17 children listed in Table 4). Each numeric entry in Table 5 indicates the number of children (of the 6 children ages 2-4) exhibiting the corresponding behavior.
- Table 6 outlines; the responses that were reported after administration of digestive enzymes the autistic children of ages 5-12 (i.e., 11 of the 17 children listed in Table 4). Again, each numeric entry in Table 6 indicates the number of children (of the 11 children ages 5-12) exhibiting the corresponding behavior.
- the results of the experiments described herein demonstrate that the fecal chymotrypsin level of an individual having one or more developmental disorders falling within the spectrum of PDD can be used as a marker to determine the benefit of administering secretin, other neuropeptides, peptides and/or digestive enzymes to the individual.
- the above experiments indicate that the administration of secretin, other neuropeptides, peptides and/or digestive enzymes to children suffering from a disorder such as autism, ADD and ADHD, for example, and having sub-normal to pathologic levels of fecal chymotrypsin, will result in the amelioration of symptomatologies of such disorders.
Abstract
Description
TABLE I | ||
6 Months Post- | ||
Pre-Secretin | Secretin | |
Autistic Children Tested | Administration | Administration |
# Autistic Children w/ Abnormal FC | 37 | 1 |
levels | ||
# Autistic Children w/ |
0 | 2 |
levels | ||
# Autistic Children w/ |
0 | 34 |
TABLE 2 | |
# ADD Children w/ Sub-normal FC levels | 28 |
# of the 28 ADD Children With Abnormal FC levels That Were | 10 |
Administered Digestive Enzymes | |
# of the 10 ADD Children That Were Administered Digestive | 4 |
Enzymes Who Were Taking Ritalin | |
#ADD Children Requiring |
0 |
Administration of Digestive Enzymes | |
TABLE 3 | |||
# ADHD Children w/ Abnormal FC levels Who Were | 9 | ||
Administered Digestive Enzymes | |||
# Of The 9 ADHD Children Whose Ritalin Levels Were | 9 | ||
Reduced 6 months Post-Digestive Enzyme Administration | |||
# Of The 9 ADHD Children Who Stopped Taking |
2 | ||
6 Months Post-Digestive Enzyme Administration | |||
TABLE 4 | |||
Pre-DE Administration | 6-Months Post-DE | ||
Fecal Chymotrypsin | Administration | ||
Patient | Age | Levels | |
1 | 2.5 | 3.3 | 7.1 |
2 | 7 | 1.5 | 3.8 |
3 | 9 | 4.0 | 7.8 |
4 | 3.5 | 2.0 | 10.2 |
5 | 5 | 3.3 | 8.0 |
6 | 4 | 1.0 | 6.8 |
7 | 8 | 1.6 | 10.2 |
8 | 6 | 4.0 | 12.2 |
9 | 7 | 6.8 | 14.9 |
10 | 3 | 2.8 | 6.2 |
11 | 5 | 3.4 | not available |
12 | 3 | 2.0 | 4.0 |
13 | 2 | 4.0 | 4.6 |
14 | 11 | 3.3 | 5.0 |
15 | 9 | 2.2 | 9.2 |
16 | 8 | 1.4 | 12.0 |
17 | 7 | 3.8 | 6.0 |
TABLE 5 | ||||
3 Months Post- | ||||
| Pre-DE | DE | 6 Months Post DE | |
some |
0 | 2 | 5 | |
toilet trained | 1 | 2 | 3 | |
some |
2 | 3 | not available | |
(not included above) | ||||
some |
2 | 3 | 6 | |
formed |
1 | 2 | 6 | |
movement | ||||
hyperactive | 5 | 3 | 1 | |
plays with |
0 | 2 | 4 | |
hand flapping | 4 | 2 | 1 | |
TABLE 6 | ||||
6 Months Post- | ||||
| Pre-DE | 3 Months Post-DE | DE | |
some |
8 | 6 | 8 |
toilet trained | 3 | 6 | 6 |
some |
2 | not available | 4 |
(not included above) | |||
some |
6 | 8 | 10 |
formed |
2 | 7 | 10 |
movement | |||
hyperactive | 9 | 5 | 3 |
plays with |
3 | 5 | 8 |
hand flapping | 6 | 5 | 1 |
Claims (10)
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Citations (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3002883A (en) | 1959-07-29 | 1961-10-03 | Dow Chemical Co | Disinfectant compositions |
US3223594A (en) | 1960-10-25 | 1965-12-14 | Philips Corp | Method of producing pancreatin |
US3357894A (en) | 1963-10-18 | 1967-12-12 | Ct Nat De La Recherche | Proteolytic enzymes of pig pancreas |
US3515642A (en) | 1965-12-06 | 1970-06-02 | Takeda Chemical Industries Ltd | Method for preparing a stabilized enzyme composition |
US3574819A (en) | 1966-12-08 | 1971-04-13 | Ciba Geigy Corp | Pharmaceutical compositions for treating digestive disorders containing 4,7- phenanthrolin - 5,6 - quinone together with pancreatin,bromelin,dehydrocholic acid and 7 - iodo - 5 - chloro-8-hydroxyquinoline |
US3940478A (en) | 1974-04-29 | 1976-02-24 | Sutures, Inc. | Proteolytic enzymes as adjuncts to antibiotic prophylaxis of contaminated wounds |
US4079125A (en) | 1975-06-10 | 1978-03-14 | Johnson & Johnson | Preparation of enteric coated digestive enzyme compositions |
US4145410A (en) | 1976-10-12 | 1979-03-20 | Sears Barry D | Method of preparing a controlled-release pharmaceutical preparation, and resulting composition |
US4241046A (en) | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
JPS62230714A (en) | 1986-03-31 | 1987-10-09 | Snow Brand Milk Prod Co Ltd | Enteric capsule |
US4826679A (en) | 1986-05-23 | 1989-05-02 | Universite De Montreal | Composition and methods for alleviating cystic fibrosis |
EP0451484A1 (en) | 1990-02-28 | 1991-10-16 | Du Pont Merck Pharmaceutical Company | Deprenyl/L-dopa/carbidopa pharmaceutical composition |
US5190775A (en) | 1991-05-29 | 1993-03-02 | Balchem Corporation | Encapsulated bioactive substances |
US5250418A (en) | 1981-10-06 | 1993-10-05 | Boehringer Mannheim Gmbh | Process and reagent for determining the activity of chymotrypsin and trypsin in feces |
EP0564739A2 (en) | 1991-10-02 | 1993-10-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Backbone cyclic peptides, processes for their preparation and pharmaceutical compositions containing them |
US5324514A (en) | 1992-06-22 | 1994-06-28 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
DE4332985A1 (en) | 1993-09-28 | 1995-03-30 | Konrad Peter Maria Dr Sommer | Pharmaceutical composition for the treatment of exocrine pancreas dysfunction |
US5436319A (en) | 1985-12-03 | 1995-07-25 | T Cell Sciences, Inc. | Cell free T cell antigen receptor beta chain and its clinical utilities |
US5437319A (en) | 1992-08-28 | 1995-08-01 | Black & Decker Inc. | Pivoting power tool with table |
US5439935A (en) | 1992-04-02 | 1995-08-08 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care method and composition |
WO1995022344A1 (en) | 1994-02-21 | 1995-08-24 | Mcgill University | Therapeutic use of myelin-associated glycoprotein (mag) |
US5460812A (en) | 1992-06-22 | 1995-10-24 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
US5476661A (en) | 1994-10-21 | 1995-12-19 | Elizabeth Arden Co., Division Of Conopco, Inc. | Compositions for topical application to skin, hair and nails |
US5527678A (en) | 1994-10-21 | 1996-06-18 | Vanderbilt University | CagB and CagC genes of helicobacter pylori and related compositions |
US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
US5607863A (en) | 1991-05-29 | 1997-03-04 | Smithkline Diagnostics, Inc. | Barrier-controlled assay device |
US5648335A (en) | 1992-06-12 | 1997-07-15 | Cephalon, Inc. | Prevention and treatment of peripheral neuropathy |
US5674532A (en) | 1989-11-24 | 1997-10-07 | Biochemie Gesellschaft M.B.H. | Pancreatin preparations |
US5686311A (en) | 1995-06-23 | 1997-11-11 | The Children's Mercy Hospital | Diagnosis of autism and treatment therefor |
US5750104A (en) | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
WO1998022499A2 (en) | 1996-11-15 | 1998-05-28 | Lisa Joan Mckerracher | Arretin, a neurite outgrowth modulator, antibodies thereto and uses thereof |
US5776917A (en) | 1991-11-25 | 1998-07-07 | The Procter & Gamble Company | Compositions for regulating skin wrinkles and/or skin atrophy |
WO1998052593A1 (en) | 1997-05-19 | 1998-11-26 | Repligen Corporation | Method for assisting in differential diagnosis and treatment of autistic syndromes |
US5858758A (en) | 1997-05-07 | 1999-01-12 | Incyte Pharmaceuticals, Inc. | Human serine protease precursor |
US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
US5958875A (en) | 1996-03-29 | 1999-09-28 | The Regents Of The University Of California | Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
US5985891A (en) | 1994-12-29 | 1999-11-16 | Rowe; James Baber | Prevention of adverse behavior, diarrhea, skin disorders and infections of the hind gut associated with acidic conditions in humans and animals by the application of antibiotics |
WO1999064059A2 (en) | 1998-06-09 | 1999-12-16 | Repligen Corporation | Use of secretin for the treatment of autism and other neurological, behavioral and immunological disorders |
US6011001A (en) | 1990-08-03 | 2000-01-04 | Vertex Pharmaceuticals, Inc. | Method of protein therapy by orally administering crosslinked protein crystals |
US6020314A (en) | 1998-08-11 | 2000-02-01 | Milkhaus Laboratory, Inc. | Methods for treatment of neurological disorders |
GB2347742A (en) | 1997-06-05 | 2000-09-13 | Royal Free Hosp School Med | Pharmaceutical composition for regressive behavioural disease |
US6153236A (en) | 1999-06-03 | 2000-11-28 | Balchem Corporation | Low melt encapsulation with high laurate canola oil |
US6187309B1 (en) | 1999-09-14 | 2001-02-13 | Milkaus Laboratory, Inc. | Method for treatment of symptoms of central nervous system disorders |
US6210950B1 (en) | 1999-05-25 | 2001-04-03 | University Of Medicine And Dentistry Of New Jersey | Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors |
WO2001027612A2 (en) | 1999-10-12 | 2001-04-19 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool |
WO2001043764A2 (en) | 1999-12-17 | 2001-06-21 | Fallon Joan M | Methods for treating pervasive development disorders |
US6251478B1 (en) | 1999-12-22 | 2001-06-26 | Balchem Corporation | Sensitive substance encapsulation |
US6261613B1 (en) | 2000-02-15 | 2001-07-17 | General Mills, Inc. | Refrigerated and shelf-stable bakery dough products |
US6280726B1 (en) | 1995-07-21 | 2001-08-28 | New York University | Type II phospholipase A2 and its use in killing Gram-positive bacteria |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
WO2002014537A2 (en) | 2000-08-14 | 2002-02-21 | Fallon Joan M | Methods for diagnosing and treating dysautonomia and other dysautonomic conditions |
US6399101B1 (en) | 2000-03-30 | 2002-06-04 | Mova Pharmaceutical Corp. | Stable thyroid hormone preparations and method of making same |
US20020081628A1 (en) | 2000-11-16 | 2002-06-27 | Fallon Joan M. | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US20020090653A1 (en) | 1999-12-17 | 2002-07-11 | Fallon Joan M. | Methods of treating pervasive development disorders |
US6482839B1 (en) | 1997-06-02 | 2002-11-19 | Cellegy Pharmaceuticals, Inc. | Pyridine-thiols for treatment of a follicular dermatosis |
US6534259B1 (en) | 1997-06-05 | 2003-03-18 | Andrew Wakefield | Regressive behavioral disorder diagnosis |
US20030097122A1 (en) | 2001-04-10 | 2003-05-22 | Ganz Robert A. | Apparatus and method for treating atherosclerotic vascular disease through light sterilization |
US20040057944A1 (en) | 2001-01-19 | 2004-03-25 | Solvay Pharmaceuticals Gmbh | Microbial enzyme mixtures useful to treat digestive disorders |
US20040057962A1 (en) | 2001-01-06 | 2004-03-25 | Benedikt Timmerman | Immunogenic complex |
US20040076590A1 (en) | 2002-07-08 | 2004-04-22 | Wilkins Joe S. | Antibacterial toothpaste and mouthwash formulations |
US6727073B1 (en) | 1999-11-19 | 2004-04-27 | Binax, Inc. | Method for detecting enteric disease |
US20040101562A1 (en) | 2000-11-15 | 2004-05-27 | Mario Maio | Microspheres of pancreatic enzymes with high stability and production method thereof |
US6743447B2 (en) | 2000-03-29 | 2004-06-01 | Roquette Freres | Pulverulent mannitol and process for preparing it |
US20040121002A1 (en) | 2002-12-23 | 2004-06-24 | Lee Phillip K. | Controlled release encapsulated bioactive substances |
US6797291B2 (en) | 2002-01-09 | 2004-09-28 | Balchem Corporation | Stable hygroscopic compositions and methods for stabilizing hygroscopic ingredients |
US20040209790A1 (en) | 2000-04-07 | 2004-10-21 | Alex Sava | Process and composition for cleaning medical instruments |
US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US20050187130A1 (en) | 2004-02-23 | 2005-08-25 | Brooker Alan T. | Granular laundry detergent composition comprising an anionic detersive surfactant, and low levels of, or no, zeolite builders and phosphate builders |
US20060105379A1 (en) | 2001-04-26 | 2006-05-18 | Shujian Wu | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 |
US7101573B2 (en) | 2001-09-28 | 2006-09-05 | Mcneil-Pcc, Inc. | Simethicone solid oral dosage form |
US20060198838A1 (en) | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
US20060259995A1 (en) | 2002-10-10 | 2006-11-16 | Diversa Corporation | Proteases, nucleic acids encoding them and methods for making and using them |
US20070053895A1 (en) | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
US20070116695A1 (en) | 2005-09-21 | 2007-05-24 | Fallon Joan M | Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders |
US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
US20080254009A1 (en) | 2000-06-05 | 2008-10-16 | Finegold Sydney M | Method of treating gastrointestinal diseases associated with species of genus clostridium |
US20080279839A1 (en) | 2005-11-01 | 2008-11-13 | Christopher Schuler | Composition With a Fungal (Yeast) Lipase and Method For Treating Lipid Malabsorption in Cystic Fibrous as Well as People Suffering From Pancreatic Lipase Insufficiency |
US20080317731A1 (en) | 2002-04-19 | 2008-12-25 | Diversa Corporation | Phospholipases, Nucleic Acids Encoding Them and Methods for Making and Using Them |
US20090232789A1 (en) | 2008-03-13 | 2009-09-17 | Fallon Joan M | Novel pharmaceutical preparation for preeclampsia, eclampsia, and toxemia, and their related symptoms and related disorders of pregnancy |
US20090263372A1 (en) | 2008-04-18 | 2009-10-22 | Fallon Joan M | Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same |
US20090324730A1 (en) | 2008-06-26 | 2009-12-31 | Fallon Joan M | Methods and compositions for the treatment of symptoms of complex regional pain syndrome |
US20090324572A1 (en) | 2008-06-26 | 2009-12-31 | Fallon Joan M | Methods and compositions for the treatment of symptoms of williams syndrome |
WO2010002972A1 (en) | 2008-07-01 | 2010-01-07 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
US20100169409A1 (en) | 2008-08-04 | 2010-07-01 | Fallon Joan M | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of parkinsons disease, movement and neurological disorders, and chronic pain |
WO2010080835A1 (en) | 2009-01-06 | 2010-07-15 | Curemark Llc | Compositions and methods for the treatment or the prevention oral infections by e. coli |
WO2010080830A1 (en) | 2009-01-06 | 2010-07-15 | Curemark Llc | Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces |
US20100260857A1 (en) | 2009-04-13 | 2010-10-14 | Joan Fallon | Enzyme delivery systems and methods of preparation and use |
Family Cites Families (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE491927A (en) | 1948-10-30 | |||
US3322626A (en) | 1963-06-13 | 1967-05-30 | Pannett Products Inc | Medicinal composition for treating acne and method of using same |
US3860708A (en) * | 1973-11-15 | 1975-01-14 | Philips Corp | Method of delivering the intestines of human beings from bariumsulphate after barium meal examination |
DE2923279B1 (en) | 1979-06-08 | 1980-11-20 | Kali Chemie Pharma Gmbh | Process for the production of pancreatin pellets |
EP0115023B1 (en) | 1982-12-30 | 1988-07-27 | Nordmark Arzneimittel GmbH | Process for obtaining pancreatin |
WO1984002846A1 (en) | 1983-01-21 | 1984-08-02 | Advanced Drug Tech | Enzyme ointment |
US4447412A (en) | 1983-02-01 | 1984-05-08 | Bilton Gerald L | Enzyme-containing digestive aid compostions |
US4456544A (en) | 1983-08-05 | 1984-06-26 | Vsesojuzny Nauchno-Issledovatelsky Biotecknichesky Institut | Enzyme-containing detergent composition for presterilization treatment of medical instruments and equipment |
DE3738599A1 (en) | 1987-11-13 | 1989-05-24 | Raps & Co Gewuerzwerk | Encapsulated dried yeast in particle form, process for the production thereof and use thereof |
CN1039706A (en) | 1988-08-04 | 1990-02-21 | 黄族和 | The preparation method of artificial Fa vegetable |
GB8821049D0 (en) | 1988-09-08 | 1988-10-05 | Health Lab Service Board | Method & composition for treatment & prevention of viral infections |
GB8923788D0 (en) | 1989-10-23 | 1989-12-13 | Unilever Plc | Enzymatic detergent compositions and their use |
US5526034A (en) * | 1990-09-28 | 1996-06-11 | Ictv, Inc. | Interactive home information system with signal assignment |
NO920067L (en) | 1991-01-14 | 1992-07-15 | Ajinomoto Kk | FORADDITIVE FOR DRUGS |
JPH04364119A (en) | 1991-06-11 | 1992-12-16 | Tsumura & Co | Bathing agent composition |
US6034678A (en) * | 1991-09-10 | 2000-03-07 | Ictv, Inc. | Cable television system with remote interactive processor |
US7242988B1 (en) | 1991-12-23 | 2007-07-10 | Linda Irene Hoffberg | Adaptive pattern recognition based controller apparatus and method and human-factored interface therefore |
DE4227385A1 (en) | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pancreatin micropellets |
DE4305460C2 (en) | 1993-02-23 | 1997-09-04 | Albert Dr Scheller | Pharmaceutical or cosmetic preparation containing enzymes, process for their preparation and their use |
JPH06339343A (en) | 1993-04-08 | 1994-12-13 | Ajinomoto Co Inc | Feed additive for ruminant |
TW310277B (en) | 1993-05-21 | 1997-07-11 | Pou Lin Fu Gin Pharm Co | The method of preparing enteric-coated pancreatin granules and its dosage forms |
GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US20080311554A1 (en) | 1994-05-06 | 2008-12-18 | Slotman Gus J | Methods for monitoring patients with severe sepsis and septic shock and for selecting treatments for these patients |
US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US6562629B1 (en) | 1999-08-11 | 2003-05-13 | Cedars-Sinai Medical Center | Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum |
EP0827402A2 (en) | 1995-05-17 | 1998-03-11 | Cedars-Sinai Medical Center | Compositions containing fatty acids for improving digestion and absorption in the small intestine |
US6558708B1 (en) | 1995-05-17 | 2003-05-06 | Cedars-Sinai Medical Center | Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia |
US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
CA2248065A1 (en) | 1996-03-06 | 1997-09-12 | Novo Nordisk A/S | A method of killing or inhibiting microbial cells |
GB2318511A (en) | 1996-10-23 | 1998-04-29 | Eurand Int | Process for the preparation of a pharmaceutical composition for rapid suspension in water |
US5860932A (en) | 1996-10-24 | 1999-01-19 | Colin Corporation | Blood pressure monitor |
US6100080A (en) | 1996-12-18 | 2000-08-08 | Novo Nordisk A/S | Method for enzymatic treatment of biofilm |
AU5670398A (en) | 1997-01-22 | 1998-08-18 | Dalgety Plc | Enzyme-based bread improvers |
US5861291A (en) | 1997-02-24 | 1999-01-19 | Biozymes Inc. | Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof |
US6234964B1 (en) | 1997-03-13 | 2001-05-22 | First Opinion Corporation | Disease management system and method |
US6205582B1 (en) * | 1997-12-09 | 2001-03-20 | Ictv, Inc. | Interactive cable television system with frame server |
KR19990072826A (en) | 1998-02-26 | 1999-09-27 | 우재영 | A process for producing enteric-coated pancreatin granules |
EP0940088A3 (en) | 1998-03-04 | 1999-12-15 | Ajinomoto Co., Inc. | Ruminant feed additive composition and process for producing the same |
US20010024660A1 (en) | 1999-09-29 | 2001-09-27 | Ismat Ullah | Enteric coated pharmaceutical composition and method of manufacturing |
AU777977B2 (en) | 1998-10-09 | 2004-11-04 | General Mills Inc. | Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles |
US6149585A (en) | 1998-10-28 | 2000-11-21 | Sage Health Management Solutions, Inc. | Diagnostic enhancement method and apparatus |
US6168569B1 (en) | 1998-12-22 | 2001-01-02 | Mcewen James Allen | Apparatus and method for relating pain and activity of a patient |
US6753306B2 (en) | 1998-12-23 | 2004-06-22 | Joseph J. Simpson | Germicidal and disinfectant composition |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
WO2000054799A2 (en) | 1999-03-17 | 2000-09-21 | Solvay Pharmaceuticals Gmbh | Medicament for treating diabetes |
US7945451B2 (en) | 1999-04-16 | 2011-05-17 | Cardiocom, Llc | Remote monitoring system for ambulatory patients |
ATE278417T1 (en) | 1999-06-18 | 2004-10-15 | Jon Bragi Bjarnason | PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING COD SERINE PROTEASES AND THE PHARMACEUTICAL AND COSMETIC USE THEREOF |
US7395216B2 (en) | 1999-06-23 | 2008-07-01 | Visicu, Inc. | Using predictive models to continuously update a treatment plan for a patient in a health care location |
US6447772B1 (en) | 1999-10-01 | 2002-09-10 | Klaire Laboratories, Inc. | Compositions and methods relating to reduction of symptoms of autism |
US20020103675A1 (en) | 1999-11-29 | 2002-08-01 | John Vanelli | Apparatus and method for providing consolidated medical information |
US6564104B2 (en) | 1999-12-24 | 2003-05-13 | Medtronic, Inc. | Dynamic bandwidth monitor and adjuster for remote communications with a medical device |
US6980958B1 (en) | 2000-01-11 | 2005-12-27 | Zycare, Inc. | Apparatus and methods for monitoring and modifying anticoagulation therapy of remotely located patients |
NZ520461A (en) | 2000-02-14 | 2005-03-24 | First Opinion Corp | Automated diagnostic system and method |
US6399114B2 (en) | 2000-05-26 | 2002-06-04 | C & D Foreman, Inc. | Nutritional system for nervous system disorders |
US6783757B2 (en) | 2000-06-01 | 2004-08-31 | Kirkman Group, Inc. | Composition and method for increasing exorphin catabolism to treat autism |
AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
AU2001283817A1 (en) | 2000-09-08 | 2002-03-22 | Novozymes A/S | A dough composition comprising a lipid-encapsulated enzyme |
US20020094367A1 (en) | 2000-09-08 | 2002-07-18 | Novozymes A/S | Dough composition |
US20020119914A1 (en) | 2000-12-26 | 2002-08-29 | Deguang Zhu | New uses of insulin and pancreatin |
US6548556B2 (en) | 2000-12-27 | 2003-04-15 | Healthpoint, Ltd. | Stable enzymatic wound debrider |
CN1150032C (en) | 2001-01-15 | 2004-05-19 | 孙芳梅 | Concentrated granular medicine for treating baby diarrhea and its preparing process |
US7588757B2 (en) | 2001-03-14 | 2009-09-15 | Genzyme Corporation | Methods of treating Parkinson's disease using recombinant adeno-associated virus virions |
US7630911B2 (en) | 2001-10-24 | 2009-12-08 | Qtc Management, Inc. | Method of automated processing of medical data for insurance and disability determinations |
AU2002364750A1 (en) | 2001-12-14 | 2003-06-30 | Solvay Pharmaceuticals Gmbh | Use of digestive enzyme mixtures for treating pathological bacterial overgrowth of the small intestine of mammals and humans |
ES2774656T3 (en) | 2002-05-03 | 2020-07-22 | Dsm Ip Assets Bv | Methods to produce high quality lipids by enzymatic release from biomass |
US20040005304A1 (en) * | 2002-07-08 | 2004-01-08 | Mak Wood, Inc. | Novel compositions and methods for treating neurological disorders and associated gastrointestinal conditions |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
EP1413202A1 (en) | 2002-10-22 | 2004-04-28 | CSM Nederland B.V. | Lipid-encapsulated functional bakery ingredients |
US20050079594A1 (en) | 2002-10-31 | 2005-04-14 | Karine Marion | Method of removing a biofilm |
US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
CA2520197A1 (en) | 2003-04-23 | 2004-11-04 | Ferring B.V. | Sachet for a pharmaceutical composition |
US7780595B2 (en) | 2003-05-15 | 2010-08-24 | Clinical Decision Support, Llc | Panel diagnostic method and system |
US7289761B2 (en) | 2003-06-23 | 2007-10-30 | Cardiac Pacemakers, Inc. | Systems, devices, and methods for selectively preventing data transfer from a medical device |
US7354569B2 (en) | 2003-07-11 | 2008-04-08 | Colgate-Palmolive Company | Chewable antiplaque confectionery dental composition |
AU2004260961B2 (en) | 2003-07-29 | 2010-05-20 | Abbott Laboratories Gmbh | Analytical method for pancreatin and comparable compositions |
US7785584B2 (en) | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
HUE044812T2 (en) * | 2003-09-23 | 2019-11-28 | Dsm Ip Assets Bv | Use of proline specific endoproteases to hydrolyse peptides and proteins |
US7381698B2 (en) | 2003-12-12 | 2008-06-03 | Chirhoclin, Inc. | Methods for treatment of acute pancreatitis |
US20050232894A1 (en) | 2004-04-20 | 2005-10-20 | Weiner Gregory M | Antimicrobial skin treatment composition and methods for producing and using an antimicrobial skin treatment composition |
AU2005247061A1 (en) | 2004-05-24 | 2005-12-08 | Novozymes A/S | Enzymes for pharmaceutical use |
ITTO20040390A1 (en) | 2004-06-10 | 2004-09-10 | Roeder 1956 Farmaceutici S P A | COMPOSITION, IN PARTICULAR FOR PHARMACEUTICAL USE, WITH ANTIOXIDANT, ANTI-INFLAMMATORY AND IMMUNOSTIMULATING ACTION. |
EP2422804A1 (en) | 2004-06-17 | 2012-02-29 | Amano Enzyme USA., Ltd. | Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers |
US7483747B2 (en) | 2004-07-15 | 2009-01-27 | Northstar Neuroscience, Inc. | Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy |
WO2006031554A2 (en) | 2004-09-10 | 2006-03-23 | Novozymes North America, Inc. | Methods for preventing, removing, reducing, or disrupting biofilm |
JP4908420B2 (en) | 2004-10-14 | 2012-04-04 | アルタス ファーマシューティカルズ インコーポレイテッド | Composition comprising lipase, protease and amylase for treating pancreatic dysfunction |
US20060115467A1 (en) * | 2004-12-01 | 2006-06-01 | Pangborn Jon B | Compositions and methods for the treatment of autism |
US20070092501A1 (en) * | 2005-04-26 | 2007-04-26 | Prothera, Inc. | Compositions and methods relating to reduction of symptoms of autism |
US20070116699A1 (en) | 2005-06-24 | 2007-05-24 | N-Zymeceuticals, Inc. | Nattokinase for reducing whole blood viscosity |
RU2413532C2 (en) | 2005-07-29 | 2011-03-10 | Зольвай Фармасьютиклз Гмбх | Method for making sterilised powdered pancreatine |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
PL1931317T3 (en) | 2005-08-15 | 2009-06-30 | Abbott Laboratories Gmbh | Pancreatin micropellets suitable for enteric coating |
US20100196344A1 (en) | 2005-10-14 | 2010-08-05 | Cystic Fibrosis Foundation Therapeutics, Inc. | Compositions and methods for treating pancreatic insufficiency |
US20070203426A1 (en) | 2005-10-20 | 2007-08-30 | Kover Arthur J | Method and apparatus for obtaining real time emotional response data over a communications network |
WO2007074454A2 (en) | 2005-12-27 | 2007-07-05 | Ramot At Tel-Aviv University Ltd. | Stable enzymatic preparations and methods of use thereof |
US8728521B2 (en) | 2005-12-27 | 2014-05-20 | Hemant N. Joshi | Physically/molecularly distributed and/or chemically bound medicaments in empty, hard capsule shells |
CN101511211A (en) | 2006-02-02 | 2009-08-19 | 帝斯曼知识产权资产管理有限公司 | Food product comprising a proline specific protease |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
KR20090034350A (en) | 2006-06-23 | 2009-04-07 | 바셀 폴리올레핀 이탈리아 에스.알.엘 | Magnesium chloroalkolate-based catalyst precursors |
US8287858B2 (en) | 2006-08-10 | 2012-10-16 | Jon Barron | Proteolytic enzyme formulations |
US20080057086A1 (en) | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
US8066986B2 (en) | 2007-02-01 | 2011-11-29 | Master Supplements, Inc. | Formulations including digestive enzymes and polysorbate surfactants that enhance the colonization of administered probiotics microoganisms |
US20080199448A1 (en) | 2007-02-16 | 2008-08-21 | Ross Mairi R | Enzyme composition for improving food digestion |
US20090117180A1 (en) | 2007-02-20 | 2009-05-07 | Giovanni Ortenzi | Stable digestive enzyme compositions |
CN103933555B (en) | 2007-02-20 | 2018-06-01 | 阿普塔利斯制药有限公司 | Stable digestive enzyme compositions |
AU2008239737A1 (en) | 2007-04-13 | 2008-10-23 | Beth Israel Deaconess Medical Center, Inc. | Novel nutritional food products for improved digestion and intestinal absorption |
JP2008283895A (en) | 2007-05-16 | 2008-11-27 | Osaka City Univ | Method for detecting diarrheagenic escherichia coli |
US20090110674A1 (en) | 2007-10-24 | 2009-04-30 | Loizou Nicos C | Health supplement |
RU2356244C1 (en) | 2007-11-12 | 2009-05-27 | Федеральное государственное учреждение "Томский научно-исследовательский институт курортологии и физиотерапии Федерального агентства по здравоохранению и социальному развитию" (ФГУ "ТНИИКиФ Росздрава") | Combination therapy of children suffering from celiac disease at health resort stage |
WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
JP2011525116A (en) | 2008-06-24 | 2011-09-15 | マイクロファーマ・リミテッド | Nitric oxide device and method of healing wounds, treating skin disorders and microbial infections |
EP2328609A1 (en) | 2008-08-26 | 2011-06-08 | Cystic Fibrosis Foundation Therapeutics, Inc. | Rapidly disintegrating tablets comprising lipase, amylase, and protease |
ATE541591T1 (en) | 2008-11-03 | 2012-02-15 | Nordmark Arzneimittel Gmbh & Co Kg | METHOD FOR REDUCING THE VIRAL AND MICROBIAL LOAD OF PANCREATIN |
CA2753444A1 (en) | 2009-02-23 | 2010-08-26 | Gopi Venkatesh | Controlled-release compositions comprising a proton pump inhibitor |
WO2011000924A1 (en) | 2009-07-03 | 2011-01-06 | Abbott Products Gmbh | Spray-dried amylase, pharmaceutical preparations comprising the same and use |
EP2295039B2 (en) | 2009-08-28 | 2022-10-26 | Nordmark Pharma GmbH | Pancreatin pellets, in particular pancreatin micropellets and method for producing same |
US20110081320A1 (en) * | 2009-10-06 | 2011-04-07 | Nubiome, Inc. | Treatment/Cure of Autoimmune Disease |
WO2011050135A1 (en) | 2009-10-21 | 2011-04-28 | Curemark Llc | Methods and compositions for the prevention and treatment of influenza |
US20110112005A1 (en) | 2009-11-12 | 2011-05-12 | Alan Thomas Brooker | Laundry Detergent Composition |
US20110200574A1 (en) | 2010-02-02 | 2011-08-18 | Jolly James F | Use of proteases for gluten intolerance |
AU2011228744A1 (en) | 2010-03-19 | 2012-10-11 | Aptalis Pharma Canada Inc. | Beta-propiolactone for inactivation of viruses in pharmaceutical pancreatic enzyme preparations |
AR093181A1 (en) | 2010-10-01 | 2015-05-27 | Aptalis Pharmatech Inc | FORMULATION WITH CONTENT OF DIGESTIVE ENZYMES UNDER STABLE |
CN103619348B (en) | 2011-04-21 | 2016-10-26 | 柯尔马克有限责任公司 | For treating the compound of neuropsychiatric disorders |
-
2000
- 2000-11-07 US US09/707,395 patent/US6632429B1/en not_active Expired - Lifetime
- 2000-12-15 WO PCT/US2000/034000 patent/WO2001043764A2/en active Application Filing
- 2000-12-15 AU AU32639/01A patent/AU3263901A/en not_active Abandoned
-
2003
- 2003-10-08 US US10/681,018 patent/US8163278B2/en not_active Expired - Lifetime
-
2005
- 2005-10-18 US US11/213,255 patent/US20060182728A1/en not_active Abandoned
- 2005-10-27 US US11/213,382 patent/US20060183180A1/en not_active Abandoned
-
2008
- 2008-03-11 US US12/046,402 patent/US8012930B2/en not_active Expired - Fee Related
- 2008-09-08 US US12/283,090 patent/US8105584B2/en not_active Expired - Fee Related
- 2008-09-25 US US12/238,415 patent/US8008036B2/en not_active Expired - Fee Related
-
2009
- 2009-06-19 US US12/487,864 patent/US8211661B2/en not_active Expired - Lifetime
-
2011
- 2011-12-07 US US13/313,708 patent/US9624526B2/en not_active Expired - Fee Related
- 2011-12-07 US US13/313,629 patent/US9624525B2/en not_active Expired - Fee Related
-
2012
- 2012-04-16 US US13/448,061 patent/US8815233B2/en not_active Expired - Fee Related
- 2012-05-25 US US13/481,087 patent/US8613918B2/en not_active Expired - Fee Related
-
2017
- 2017-02-23 US US15/440,942 patent/US20170157221A1/en not_active Abandoned
-
2018
- 2018-06-18 US US16/010,850 patent/US20180296650A1/en not_active Abandoned
Patent Citations (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3002883A (en) | 1959-07-29 | 1961-10-03 | Dow Chemical Co | Disinfectant compositions |
US3223594A (en) | 1960-10-25 | 1965-12-14 | Philips Corp | Method of producing pancreatin |
US3357894A (en) | 1963-10-18 | 1967-12-12 | Ct Nat De La Recherche | Proteolytic enzymes of pig pancreas |
US3515642A (en) | 1965-12-06 | 1970-06-02 | Takeda Chemical Industries Ltd | Method for preparing a stabilized enzyme composition |
US3574819A (en) | 1966-12-08 | 1971-04-13 | Ciba Geigy Corp | Pharmaceutical compositions for treating digestive disorders containing 4,7- phenanthrolin - 5,6 - quinone together with pancreatin,bromelin,dehydrocholic acid and 7 - iodo - 5 - chloro-8-hydroxyquinoline |
US3940478A (en) | 1974-04-29 | 1976-02-24 | Sutures, Inc. | Proteolytic enzymes as adjuncts to antibiotic prophylaxis of contaminated wounds |
US4079125A (en) | 1975-06-10 | 1978-03-14 | Johnson & Johnson | Preparation of enteric coated digestive enzyme compositions |
US4145410A (en) | 1976-10-12 | 1979-03-20 | Sears Barry D | Method of preparing a controlled-release pharmaceutical preparation, and resulting composition |
US4241046A (en) | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US5250418A (en) | 1981-10-06 | 1993-10-05 | Boehringer Mannheim Gmbh | Process and reagent for determining the activity of chymotrypsin and trypsin in feces |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
US5436319A (en) | 1985-12-03 | 1995-07-25 | T Cell Sciences, Inc. | Cell free T cell antigen receptor beta chain and its clinical utilities |
JPS62230714A (en) | 1986-03-31 | 1987-10-09 | Snow Brand Milk Prod Co Ltd | Enteric capsule |
US4826679A (en) | 1986-05-23 | 1989-05-02 | Universite De Montreal | Composition and methods for alleviating cystic fibrosis |
US5674532A (en) | 1989-11-24 | 1997-10-07 | Biochemie Gesellschaft M.B.H. | Pancreatin preparations |
EP0451484A1 (en) | 1990-02-28 | 1991-10-16 | Du Pont Merck Pharmaceutical Company | Deprenyl/L-dopa/carbidopa pharmaceutical composition |
US6011001A (en) | 1990-08-03 | 2000-01-04 | Vertex Pharmaceuticals, Inc. | Method of protein therapy by orally administering crosslinked protein crystals |
US6013286A (en) | 1991-05-29 | 2000-01-11 | Balchem Corporation | Encapsulated bioactive substances |
US5190775A (en) | 1991-05-29 | 1993-03-02 | Balchem Corporation | Encapsulated bioactive substances |
US5607863A (en) | 1991-05-29 | 1997-03-04 | Smithkline Diagnostics, Inc. | Barrier-controlled assay device |
EP0564739A2 (en) | 1991-10-02 | 1993-10-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Backbone cyclic peptides, processes for their preparation and pharmaceutical compositions containing them |
US5776917A (en) | 1991-11-25 | 1998-07-07 | The Procter & Gamble Company | Compositions for regulating skin wrinkles and/or skin atrophy |
US5439935A (en) | 1992-04-02 | 1995-08-08 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care method and composition |
US5648335A (en) | 1992-06-12 | 1997-07-15 | Cephalon, Inc. | Prevention and treatment of peripheral neuropathy |
US5324514A (en) | 1992-06-22 | 1994-06-28 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
US5460812A (en) | 1992-06-22 | 1995-10-24 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
US5437319A (en) | 1992-08-28 | 1995-08-01 | Black & Decker Inc. | Pivoting power tool with table |
DE4332985A1 (en) | 1993-09-28 | 1995-03-30 | Konrad Peter Maria Dr Sommer | Pharmaceutical composition for the treatment of exocrine pancreas dysfunction |
WO1995022344A1 (en) | 1994-02-21 | 1995-08-24 | Mcgill University | Therapeutic use of myelin-associated glycoprotein (mag) |
US5476661A (en) | 1994-10-21 | 1995-12-19 | Elizabeth Arden Co., Division Of Conopco, Inc. | Compositions for topical application to skin, hair and nails |
US5527678A (en) | 1994-10-21 | 1996-06-18 | Vanderbilt University | CagB and CagC genes of helicobacter pylori and related compositions |
US5985891A (en) | 1994-12-29 | 1999-11-16 | Rowe; James Baber | Prevention of adverse behavior, diarrhea, skin disorders and infections of the hind gut associated with acidic conditions in humans and animals by the application of antibiotics |
US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
US5686311A (en) | 1995-06-23 | 1997-11-11 | The Children's Mercy Hospital | Diagnosis of autism and treatment therefor |
US6280726B1 (en) | 1995-07-21 | 2001-08-28 | New York University | Type II phospholipase A2 and its use in killing Gram-positive bacteria |
US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US5958875A (en) | 1996-03-29 | 1999-09-28 | The Regents Of The University Of California | Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
US5750104A (en) | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
WO1998022499A2 (en) | 1996-11-15 | 1998-05-28 | Lisa Joan Mckerracher | Arretin, a neurite outgrowth modulator, antibodies thereto and uses thereof |
WO1998022499A3 (en) | 1996-11-15 | 1998-07-30 | Lisa Joan Mckerracher | Arretin, a neurite outgrowth modulator, antibodies thereto and uses thereof |
US5858758A (en) | 1997-05-07 | 1999-01-12 | Incyte Pharmaceuticals, Inc. | Human serine protease precursor |
US6020310A (en) | 1997-05-19 | 2000-02-01 | Repligen Corporation | Method for assisting in differential diagnosis and treatment of autistic syndromes |
WO1998052593A1 (en) | 1997-05-19 | 1998-11-26 | Repligen Corporation | Method for assisting in differential diagnosis and treatment of autistic syndromes |
US6482839B1 (en) | 1997-06-02 | 2002-11-19 | Cellegy Pharmaceuticals, Inc. | Pyridine-thiols for treatment of a follicular dermatosis |
US6534259B1 (en) | 1997-06-05 | 2003-03-18 | Andrew Wakefield | Regressive behavioral disorder diagnosis |
GB2347742A (en) | 1997-06-05 | 2000-09-13 | Royal Free Hosp School Med | Pharmaceutical composition for regressive behavioural disease |
US6197746B1 (en) | 1998-05-19 | 2001-03-06 | Repligen Corporation | Method of using secretin for treating autism |
WO1999064059A3 (en) | 1998-06-09 | 2000-03-02 | Repligen Corp | Use of secretin for the treatment of autism and other neurological, behavioral and immunological disorders |
WO1999064059A2 (en) | 1998-06-09 | 1999-12-16 | Repligen Corporation | Use of secretin for the treatment of autism and other neurological, behavioral and immunological disorders |
WO2000009142A1 (en) | 1998-08-11 | 2000-02-24 | Milkhaus Laboratory, Inc. | Methods for treatment of neurological disorders |
US6020314A (en) | 1998-08-11 | 2000-02-01 | Milkhaus Laboratory, Inc. | Methods for treatment of neurological disorders |
US6210950B1 (en) | 1999-05-25 | 2001-04-03 | University Of Medicine And Dentistry Of New Jersey | Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors |
US6153236A (en) | 1999-06-03 | 2000-11-28 | Balchem Corporation | Low melt encapsulation with high laurate canola oil |
US6187309B1 (en) | 1999-09-14 | 2001-02-13 | Milkaus Laboratory, Inc. | Method for treatment of symptoms of central nervous system disorders |
WO2001027612A2 (en) | 1999-10-12 | 2001-04-19 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool |
WO2001027612A3 (en) | 1999-10-12 | 2001-10-11 | Connex Ges Zur Optimierung Von | Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool |
US7129053B1 (en) | 1999-10-12 | 2006-10-31 | Dakocytomation Denmark A/S | Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool |
US6727073B1 (en) | 1999-11-19 | 2004-04-27 | Binax, Inc. | Method for detecting enteric disease |
WO2001043764A2 (en) | 1999-12-17 | 2001-06-21 | Fallon Joan M | Methods for treating pervasive development disorders |
US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
US20040071683A1 (en) | 1999-12-17 | 2004-04-15 | Fallon Joan M. | Methods for treating pervasive development disorders |
US20090130081A1 (en) | 1999-12-17 | 2009-05-21 | Fallon Joan M | Method for treating pervasive development disorders |
US20020090653A1 (en) | 1999-12-17 | 2002-07-11 | Fallon Joan M. | Methods of treating pervasive development disorders |
US20090286270A1 (en) | 1999-12-17 | 2009-11-19 | Fallon Joan M | Method for treating pervasive development disorders |
US6534063B1 (en) | 1999-12-17 | 2003-03-18 | Joan M. Fallon | Methods for treating pervasive development disorders |
WO2001043764A3 (en) | 1999-12-17 | 2001-11-29 | Joan M Fallon | Methods for treating pervasive development disorders |
US20060183180A1 (en) | 1999-12-17 | 2006-08-17 | Fallon Joan M | Methods for treating pervasive development disorders |
US20090197289A1 (en) | 1999-12-17 | 2009-08-06 | Fallon Joan M | Method for confirming a diagnosis of autism |
US20060182728A1 (en) | 1999-12-17 | 2006-08-17 | Joan Fallon | Methods for treating pervasive development disorders |
US6251478B1 (en) | 1999-12-22 | 2001-06-26 | Balchem Corporation | Sensitive substance encapsulation |
US6261613B1 (en) | 2000-02-15 | 2001-07-17 | General Mills, Inc. | Refrigerated and shelf-stable bakery dough products |
US6743447B2 (en) | 2000-03-29 | 2004-06-01 | Roquette Freres | Pulverulent mannitol and process for preparing it |
US6399101B1 (en) | 2000-03-30 | 2002-06-04 | Mova Pharmaceutical Corp. | Stable thyroid hormone preparations and method of making same |
US20040209790A1 (en) | 2000-04-07 | 2004-10-21 | Alex Sava | Process and composition for cleaning medical instruments |
US20080254009A1 (en) | 2000-06-05 | 2008-10-16 | Finegold Sydney M | Method of treating gastrointestinal diseases associated with species of genus clostridium |
WO2002014537A2 (en) | 2000-08-14 | 2002-02-21 | Fallon Joan M | Methods for diagnosing and treating dysautonomia and other dysautonomic conditions |
US20090285790A1 (en) | 2000-08-14 | 2009-11-19 | Fallon Joan M | Methods of treating and diagnosing parkinsons disease and related dysautonomic disorders |
US20020037284A1 (en) | 2000-08-14 | 2002-03-28 | Fallon Joan M. | Method for diagnosing and treating dysautonomia and other dysautonomic conditions |
US20070053895A1 (en) | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
US7138123B2 (en) | 2000-08-14 | 2006-11-21 | Fallon Joan M | Methods for diagnosing and treating dysautonomia and other dysautonomic conditions |
WO2002014537A3 (en) | 2000-08-14 | 2002-05-10 | Joan M Fallon | Methods for diagnosing and treating dysautonomia and other dysautonomic conditions |
US20080152637A1 (en) | 2000-08-14 | 2008-06-26 | Fallon Joan M | Methods of treating and diagnosing parkinsons disease and related dysautonomic disorders |
US6660831B2 (en) | 2000-08-14 | 2003-12-09 | Joan M. Fallon | Method for diagnosing and treating dysautonomia and other dysautonomic conditions |
US20040101562A1 (en) | 2000-11-15 | 2004-05-27 | Mario Maio | Microspheres of pancreatic enzymes with high stability and production method thereof |
US20020081628A1 (en) | 2000-11-16 | 2002-06-27 | Fallon Joan M. | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US20040057962A1 (en) | 2001-01-06 | 2004-03-25 | Benedikt Timmerman | Immunogenic complex |
US20040057944A1 (en) | 2001-01-19 | 2004-03-25 | Solvay Pharmaceuticals Gmbh | Microbial enzyme mixtures useful to treat digestive disorders |
US20030097122A1 (en) | 2001-04-10 | 2003-05-22 | Ganz Robert A. | Apparatus and method for treating atherosclerotic vascular disease through light sterilization |
US20060105379A1 (en) | 2001-04-26 | 2006-05-18 | Shujian Wu | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 |
US7101573B2 (en) | 2001-09-28 | 2006-09-05 | Mcneil-Pcc, Inc. | Simethicone solid oral dosage form |
US6797291B2 (en) | 2002-01-09 | 2004-09-28 | Balchem Corporation | Stable hygroscopic compositions and methods for stabilizing hygroscopic ingredients |
US20080317731A1 (en) | 2002-04-19 | 2008-12-25 | Diversa Corporation | Phospholipases, Nucleic Acids Encoding Them and Methods for Making and Using Them |
US20040076590A1 (en) | 2002-07-08 | 2004-04-22 | Wilkins Joe S. | Antibacterial toothpaste and mouthwash formulations |
US20060259995A1 (en) | 2002-10-10 | 2006-11-16 | Diversa Corporation | Proteases, nucleic acids encoding them and methods for making and using them |
US20040121002A1 (en) | 2002-12-23 | 2004-06-24 | Lee Phillip K. | Controlled release encapsulated bioactive substances |
US6835397B2 (en) | 2002-12-23 | 2004-12-28 | Balchem Corporation | Controlled release encapsulated bioactive substances |
US20050187130A1 (en) | 2004-02-23 | 2005-08-25 | Brooker Alan T. | Granular laundry detergent composition comprising an anionic detersive surfactant, and low levels of, or no, zeolite builders and phosphate builders |
US20080166334A1 (en) | 2004-09-28 | 2008-07-10 | Fallon Joan M | Combination enzyme for cystic fibrosis |
US20100233218A1 (en) | 2004-09-28 | 2010-09-16 | Curemark Llc | Combination enzyme for cystic fibrosis |
US20060198838A1 (en) | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
US20080161265A1 (en) | 2005-08-30 | 2008-07-03 | Fallon Joan M | Use of lactulose in the treatment of autism |
US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
US20070116695A1 (en) | 2005-09-21 | 2007-05-24 | Fallon Joan M | Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders |
US20080279839A1 (en) | 2005-11-01 | 2008-11-13 | Christopher Schuler | Composition With a Fungal (Yeast) Lipase and Method For Treating Lipid Malabsorption in Cystic Fibrous as Well as People Suffering From Pancreatic Lipase Insufficiency |
US20090232789A1 (en) | 2008-03-13 | 2009-09-17 | Fallon Joan M | Novel pharmaceutical preparation for preeclampsia, eclampsia, and toxemia, and their related symptoms and related disorders of pregnancy |
WO2009114757A2 (en) | 2008-03-13 | 2009-09-17 | Fallon Joan M | A novel pharmaceutical preparation for preeclampsia, eclampsia, and toxemia and their related symptoms and related disorders of pregnancy |
US20090263372A1 (en) | 2008-04-18 | 2009-10-22 | Fallon Joan M | Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same |
US20090324572A1 (en) | 2008-06-26 | 2009-12-31 | Fallon Joan M | Methods and compositions for the treatment of symptoms of williams syndrome |
US20090324730A1 (en) | 2008-06-26 | 2009-12-31 | Fallon Joan M | Methods and compositions for the treatment of symptoms of complex regional pain syndrome |
WO2010002972A1 (en) | 2008-07-01 | 2010-01-07 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US20100169409A1 (en) | 2008-08-04 | 2010-07-01 | Fallon Joan M | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of parkinsons disease, movement and neurological disorders, and chronic pain |
US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
WO2010080835A1 (en) | 2009-01-06 | 2010-07-15 | Curemark Llc | Compositions and methods for the treatment or the prevention oral infections by e. coli |
WO2010080830A1 (en) | 2009-01-06 | 2010-07-15 | Curemark Llc | Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces |
US20100260857A1 (en) | 2009-04-13 | 2010-10-14 | Joan Fallon | Enzyme delivery systems and methods of preparation and use |
Non-Patent Citations (261)
Title |
---|
"NINDS Dysautonimia Information Page," retrieved from the internet Sep. 10, 2009, www.ninds.nih.gov/disorders/dysautonomia/dysautonomia.htm. |
"NINDS Guillain-Barre Syndrome Information Page," retrieved from the internet Sep. 15, 2009, www.ninds.nih.gov/disorders/gbs/gbs.htm. |
Adams. "Summary of Defeat Autism Now! (DNN!) Oct. 2001 Conference," retrieved from the internet Dec. 18, 2008. puterakembara.org/rm/DAN2001.htm. |
Advisory Action dated Jun. 3, 2008 for U.S. Appl. No. 10/681,018. |
Amendment and Response dated Apr. 7, 2010 in Reply to Restriction Requirement dated Oct. 7, 2009 for U.S. Appl. No. 12/283,090. |
Amendment and Response dated Jun. 30, 2010 to Restriction Requirement dated Jan. 13, 2010 for U.S. Appl. No. 12/487,868. |
Amendment dated Aug. 19, 2009 in Reply to Notice Non-Compliant Amendment dated Jun. 19, 2009 for U.S. Appl. No. 11/232,180. |
Amendment dated Aug. 21, 2008 in Reply to Office Action dated Apr. 21, 2008 for U.S. Appl. No. 11/232,180. |
Amendment dated Aug. 28, 2008 in Reply to Office Action dated Mar. 28, 2008 for U.S. Appl. No. 11/555,697. |
Amendment dated Dec. 12, 2007 in Reply to Office Action dated Aug. 8, 2007 for U.S. Appl. No. 11/213,382. |
Amendment dated Dec. 7, 2007 in Reply to Office Action dated Aug. 7, 2007 for U.S. Appl. No. 10/681,018. |
Amendment dated Feb. 2, 2004 in Reply to Office Action dated Jul. 29, 2003 for U.S. Appl. No. 09/990,909. |
Amendment dated Feb. 29, 2008 in Reply to Notice of Non-Responsive Amendment dated Feb. 11, 2008 for U.S. Appl. No. 11/555,697. |
Amendment dated Feb. 7, 2003 in Reply to Office Action dated Jul. 30, 2002 for U.S. Appl. No. 09/990,909. |
Amendment dated Feb. 7, 2009 in Reply to Office Action dated Aug. 18, 2008 for U.S. Appl. No. 10/681,018. |
Amendment dated Jul. 2, 2008 in Reply to Notice of Non-Compliant Amendment dated Jun. 2, 2008 for U.S. Appl. No. 12/046,252. |
Amendment dated Jun. 15, 2009 in Reply to Final Office Action dated Mar. 13, 2009 for U.S. Appl. No. 11/232,180. |
Amendment dated Jun. 8, 2007 in Reply to Restriction Requirement dated May 9, 2007 for U.S. Appl. No. 11/213,382. |
Amendment dated Jun. 8, 2010 in Reply to Office Action dated Jan. 8, 2010 for U.S. Appl. No. 10/681,018. |
Amendment dated Mar. 1, 2004 in Reply to Office Action dated Aug. 26, 2003 for U.S. Appl. No. 10/041,073. |
Amendment dated Mar. 24, 2010 in Reply to Final Office Action dated Jul. 2, 2010 for U.S. Appl. No. 12/046,252. |
Amendment dated Mar. 24, 2010 in Reply to Office Action dated Sep. 24, 2009 for U.S. Appl. No. 12/046,252. |
Amendment dated Mar. 3, 2008 to Restriction Requirement dated Jan. 10, 2008 for U.S. Appl. No. 11/232,180. |
Amendment dated Mar. 4, 2008 in Reply to Office Action dated Nov. 14, 2007 for U.S. Appl. No. 11/213,255. |
Amendment dated May 18, 2007 in Reply to Office Action dated Dec. 22, 2006 for U.S. Appl. No. 10/681,018. |
Amendment dated May 19, 2008 in Reply to Final Office Action dated Mar. 17, 2008 for U.S. Appl. No. 10/681,018. |
Amendment dated May 27, 2009 in Reply to Final Office Action dated Feb. 27, 2009 for U.S. Appl. No. 11/555,697. |
Amendment dated Nov. 13, 2009 in Reply to Final Office Action dated Jul. 27, 2004 for U.S. Appl. No. 09/990,909. |
Amendment dated Nov. 17, 2007 in Reply to Restriction Requirement dated Oct. 17, 2007 for U.S. Appl. No. 11/555,697. |
Amendment dated Oct. 20, 2008 in Reply to Notice Non-responsive Amendment dated Sep. 22, 2008 for U.S. Appl. No. 11/232,180. |
Amendment dated Oct. 24, 2008 in Reply to Notice of Non-Responsive Amendment dated Sep. 25, 2008 for U.S. Appl. No. 11/555,697. |
Amendment dated Oct. 28, 2009 in Reply to Final Office Action dated Apr. 28, 2009 for U.S. Appl. No. 10/681,018. |
Amendment dated Sep. 24, 2007 in Reply to Restriction Requirement dated Jun. 22, 2007 for U.S. Appl. No. 11/213,255. |
Amendment dated Sep. 25, 2008 in Reply to Final Office Action dated Jun. 25, 2008 for U.S. Appl. No. 11/213,255. |
Amendment in Response dated May 23, 2003 to Restriction Requirement dated Apr. 23, 2003 for U.S. Appl. No. 09/990,909. |
Ang, et al. Biological role and regulation of the universally conserved heat shock proteins. J Biol Chem. Dec. 25, 1991;266(36):24233-6. |
Arribas, et al. A comparative study of the chymotrypsin-like activity of the rat liver multicatalytic proteinase and the ClpP from Escherichia coli. J Biol Chem. Oct. 5, 1993;268(28):21165-71. (abstract only). |
Arrigo, et al. Expression of heat shock proteins during development in Drosophila. Results Probl Cell Differ. 1991;17:106-19. (abstract only). |
Austic. Development and adaptation of protein digestion. J Nutr. May 1985;115(5):686-97. |
Awazuhara, et al. Antigenicity of the proteins in soy lecithin and soy oil in soybean allergy. Clin Exp Allergy. Dec. 1998;28(12):1559-64. |
Axcan Pharma Inc. Cdn Prescribing Information on VIOKASE Pancrelipase, USP tablets, powder. 2000: 1-3. |
Axelrod. Secretin Treatment for Gastrointestinal Dysmobility in Patients with Familial Dysautonomia. New York University School of Medicine, Grant Recipient awards, Mar.-May 2000. www.med.nyu.edu/ogars/awards/awards2000/page2.html. |
Azilect et al. "Correlation between protein intake and daily levodopa dosage," Obtained from the internet May 2, 2007, www.azilect.eu/media/cnsnews/showitem.aspx?i=d1c603e4-3c61-4aal-a376-6e519a5a0f80. |
Barlow. A comparison of the blood pressure, kidney volume and the pancreatic secretory response following the vein administration of various secretin preparations. Am J Phys. 1927;81:182-188. |
Beilmann, et al. Neoexpression of the c-met/hepatocyte growth factor-scatter factor receptor gene in activated monocytes. Blood. Dec. 1, 1997;90(11):4450-8. |
Belmonte et al. Fragile X syndrome and autism at the intersection of genetic and neural networks. Nat Neurosci. Oct. 2006; 9(10):1221-5 (abstract only). |
Blackmer. Parkinson disease: treatment and medication. Mar. 10, 2009., retrieved from the internet on Sep. 15, 2009, emedicine.medscape.com/article/312519-treatment. |
Bode et al. Usefulness of a simple photometric determination of chymotrypsin activity in stools-results of a multicentre study. Clin Biochem. 1986; 19:333-37. |
Bode et al. Usefulness of a simple photometric determination of chymotrypsin activity in stools—results of a multicentre study. Clin Biochem. 1986; 19:333-37. |
Borowitz, et al. Use of pancreatic enzyme supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. Consensus Committee. J Pediatr. Nov. 1995;127(5):681-4. |
Boyd, et al. Positively charged amino acid residues can act as topogenic determinants in membrane proteins. Proc Natl Acad Sci U S A. Dec. 1989;86(23):9446-50. |
Brudnak et al. Enzyme-based therapy for autism spectrum disorders-is it worth another look? Med Hypoth. 2002; 58:422-428. |
Brudnak et al. Enzyme-based therapy for autism spectrum disorders—is it worth another look? Med Hypoth. 2002; 58:422-428. |
Bruhat, et al. Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. J Biol Chem. Jul. 11, 1997;272(28):17588-93. |
Campbell et al. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci USA. 2006; 103(45):16834-16839. |
Carlton. Autism and malnutrition: the milk connection. Retrieved from the internet on Feb. 18, 2008, www.mercola.com/2004/autism-malnutrition.htm. |
Carlton. Autism and malnutrition: the milk connection. Retrieved from the internet on Feb. 18, 2008, www.mercola.com/2004/autism—malnutrition.htm. |
Carroccio, et al. Secondary impairment of pancreatic function as a cause of severe malabsorption in intestinal giardiasis: a case report. Am J Trop Med Hyg. Jun. 1997;56(6):599-602. (abstract only). |
Carroccio, et al. Secretin-cerulein test and fecal chymotrypsin concentration in children with intestinal giardiasis. Int J Pancreatol. Oct. 1993;14(2):175-80. |
Cassidy, et al. A new concept for the mechanism of action of chymotrypsin: the role of the low-barrier hydrogen bond. Biochemistry. Apr. 15, 1997;36(15):4576-84. |
Chen, et al. Identification of two lysosomal membrane glycoproteins. J Cell Biol. Jul. 1985;101(1):85-95. |
Cichoke, et al. The complete book of enzyme therapy. Penguin. 1998: 39, 42, 47, 50, and 53. |
Corring, et al. Development of digestive enzymes in the piglet from birth to 8 weeks. I. Pancreas and pancreatic enzymes. Nutr Metab. 1978;22(4):231-43. |
Couet, et al. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem. Mar. 7, 1997;272(10):6525-33. |
Craig, et al. Heat shock proteins: molecular chaperones of protein biogenesis. Microbiol Rev. Jun. 1993;57(2):402-14. |
Croonenberghs, et al. Peripheral markers of serotonergic and noradrenergic function in post-pubertal, Caucasian males with autistic disorder. Neuropsychopharmacology. Mar. 2000;22(3):275-83. |
Cruse et al. Illustrated dictionary of immunology. CRC Press, New York. 1995. |
Darman. An introduction to alternative medicine for psychiactric conditions. Oct. 22, 2007, retrieved on Sep. 18, 2009, web.archive.org/web/20071022104238/altp[therapies4bipolar.info/ortho/html. |
Digestive Enzyme, retrieved from the internet Sep. 10, 2009, http://en.wikipedia.org/wiki/Digestive-enzyme. |
Digestive Enzyme, retrieved from the internet Sep. 10, 2009, http://en.wikipedia.org/wiki/Digestive—enzyme. |
Dobbs et al. Link between Helicobacter pylori infection and idiopathic parkinsonism. Medical Hypothsis. 2000: 55(2):93-98. |
Dockter et al. Determination of chymotrypsin in the feces by a new photometric method. Padiatr Padol. 1985; 20(3):257-265. |
Edelson, et al. 3-Cyclohexene-l-glycine, an Isoleucine Antagonist. J. Am. Chem. Soc. 1958; 80(11):2698-2700. (abstract only). |
Ethridge, et al. Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1. Pancreas. Oct. 2000;21(3):248-56. (abstract only). |
Fafournoux, et al. Amino acid regulation of gene expression. Biochem J. Oct. 1, 2000;351(Pt 1):1-12. |
Fallingborg, et al. Measurement of gastrointestinal pH and regional transit times in normal children. J Pediatr Gastroenterol Nutr. Aug. 1990;11(2):211-4. |
Filipek et al. The screening and diagnosis of autistic spectrum disorders. J. of Autism and Dev Disorders. 1999; 29(6). |
Final Office Action dated Apr. 28, 2009 for U.S. Appl. No. 10/681,018. |
Final Office Action dated Feb. 14, 2011 for U.S. Appl. No. 12/049,613. |
Final Office Action dated Feb. 27, 2009 for U.S. Appl. No. 11/555,697. |
Final Office Action dated Jul. 2, 2010 for U.S. Appl. No. 12/046,252. |
Final Office Action dated Jul. 27, 2004 for U.S. Appl. No. 09/990,909. |
Final Office Action dated Jun. 25, 2008 for U.S. Appl. No. 11/213,255. |
Final Office Action dated Mar. 13, 2009 for U.S. Appl. No. 11/232,180. |
Final Office Action dated Mar. 17, 2008 for U.S. Appl. No. 10/681,018. |
Final Office Action dated May 11, 2010 for U.S. Appl. No. 11/555,697. |
Final Office Action dated Nov. 19, 2010 for U.S. Appl. No. 09/990,909. |
Finegold et al. Gastrointestinal microflora studies in late-onset autism. Clinical Infectious Diseases. 2002; 35(1):S6-S15. |
Fitzsimmons, et al. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N Engl J Med. May 1, 1997;336(18):1283-9. |
Garcia et al. Detection of giardia lamblia, entamoeba histolytica/entamoeba dispar, and Cryptosporidium parvum antigens in human fecal specimens using the triage parasite panel enzyme immunoassay. Am Soc for Microbiology. 2000; 38(9):3337-3340. |
Gardner. Absorption of intact peptides: studies on transport of protein digests and dipeptides across rat small intestine in vitro. Q J Exp Physiol. Oct. 1982;67(4):629-37. |
Garner Jr, et al. Porcine Pancreatic Lipase—A Glycoprotein. J Biol Chem. Jan. 25, 1972;247(2):561-5. |
Giglio, et al. Failure to thrive: the earliest feature of cystic fibrosis in infants diagnosed by neonatal screening. Acta Paediatr. Nov. 1997;86(11):1162-5. |
Goff, et al. Production of abnormal proteins in E. coli stimulates transcription of Ion and other heat shock genes. Cell. Jun. 1985;41(2):587-95. (abstract only). |
Green, et al. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. Aug. 16, 1994;33(32):9414-9. |
Gupta, et al. Thl- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol. May 1, 1998;85(1):106-9. |
Hadjivassiliou, et al. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. Feb. 10, 1996;347(8998):369-71. |
Happe et al. The neuropsychology of autism. Brain. 1996; 119:1377-1400. |
Happe et al. Time to give up on a simple explanation for autism. Nat Neurosci. Oct. 2006; 9(10):1218-20. |
Heijerman, et al. Omeprazole enhances the efficacy of pancreatin (pancrease) in cystic fibrosis. Ann Intern Med. Feb. 1, 1991;114(3):200-1. |
Hendren et al. Mechanistic biomarkers for autism treatment. Medical Hypotheses. 2009; 73:950-954. |
Horvath et al. Improved social and language skills after secretin administration in patients with autistic spectrum disorders. Journal of the Association for Academic Minority Physicians. Jan. 1998; 9(1):9-15. |
Horvath, et al. Gastrointestinal abnormalities in children with autistic disorder. J Pediatr. Nov. 1999;135(5):559-63. |
Hoshiko et al. The effect of the gastrointestinal hormones on colonic muscosal blood flow. Acta Medica Nagasakiensia. 1994; 39(4):125-130. |
Huang, et al. Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases. Hum Mol Genet. Oct. 1997;6(11):1879-85. |
Huang, et al. Mapping of the human APOB gene to chromosome 2p and demonstration of a two-allele restriction fragment length polymorphism. Proc Natl Acad Sci U S A. Feb. 1986;83(3):644-8. |
International search report and written opinion dated Feb. 15, 2011 for PCT/US2010/053484. |
International search report and written opinion dated Jan. 18, 2011 for PCT/US2010/057341. |
International search report and written opinion dated Jun. 9, 2010 for PCT/US2010/030895. |
International search report and written opinion dated Mar. 2, 2010 for PCT/US2010/020253. |
International search report and written opinion dated Sep. 25, 2009 for PCT/US0949374. |
International search report and written opnion dated Mar. 5, 2010 for PCT/US2010/020259. |
International search report dated Jun. 29, 2001 for PCT/US2000/34000. |
International search report dated Mar. 11, 2002 for PCT/US2001/25343. |
Juhl. Fibromyalgia and the serotonin pathway. Altern Med Rev. 1998; 3(5):367-375. |
Kachrimanis, et al. Tensile strength and disintegration of tableted silicified microcrystalline cellulose: influences of interparticle bonding. J Pharm Sci. Jul. 2003;92(7):1489-501. |
Kaspar et al. New photometric assay for chymotrypsin in stool. Clinical Chemistry. 1984; 30(11):1753-1757. |
Koller, et al. Falls and Parkinson's Disease (Abstract). Clin Neuropharmacol. 1989; 12(2):98-105. (abstract only). |
Koster et al. Evidence based medicine and extradigestive manifestations of Helocobacter pylori. Acta Gastro-Enterologica Belgica. 2000; 63(4):388-392. |
Layer et al. Pancreatin enzyme replacement therapy. Current Gastroenterology Reports. 2001; 3:101-108. |
Levy, et al. Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biol Psychiatry. Feb. 15, 2007;61(4):492-7. |
Lieberman. Pharmaceutical Dosage Forms. vol. 2: Disperse Systems. New York Marcel Dekker, Inc. 1996; 243-258. |
LIPASE 30, Technical Data sheet, 1 page, Scientific Protein Laboratories LLC Jun. 13, 2005. |
Lloyd. Lysosome membrane permeability: implications for drug delivery. Adv Drug Deliv Rev. Mar. 30, 2000;41(2):189-200. (abstract only). |
Luedtke, et al. Cathepsin A is expressed in a cell- and region-specific manner in the testis and epididymis and is not regulated by testicular or pituitary factors. J Histochem Cytochem. Aug. 2000;48(8):1131-46. |
Macready. Parkinson's Diseasne Treatment: what you should know. Retrieved from the internet on Sep. 15, 2009, www.everydayhealth.com/parkinsons-disease-treatment-overview.aspx. |
Mannino, et al. Surveillance for asthma—United States, 1960-1995. MMWR CDC Surveill Summ. Apr. 24, 1998;47(1):1-27. |
Marczewska et al. Protein intake in parkinsonian using the EPIC food frequency questionnaire. Mov Diord. Aug. 2006; 21(8):1229-1231. |
Marlicz et al. Determination of chymotrypsin in the stool in the diagnosis of chronic pancreatitis. Wiadomosci lekarskie. 1988; 41(11):704-707. (Not in English). |
Marsh. Neuropsychiatric aspects of parkinson's disease. Psychosomatics. 2000; 41(1):15-23. |
Mayo Clinic Staff. Autism. Retrieved from internet Mar. 10, 2008, www.mayoclinic.com/health/autism/DS00348DSECTION=2. |
Mayo Clinic Staff. Bipolar disorder. Jan. 4, 2008, www.mayoclinic.com/health/bipolardisorder/DS00356/DSECTION=symptoms. |
Mayo Clinic Staff. Obsessive-compulsive disorder. Dec. 21, 2006. www.preferredalternatives.org/lat/WellnessLibrary/anxiety&PanicDisorders/Obsessive-CompulsiveDisorder/Obsessive-CompulsiveDisorder-Mayoclinic.pdf. |
Mayo Clinic Staff. Oppositional defiant disorder. Dec. 19, 2007, www.mayoclinic.com/health/oppositional-defiant-disorder/DS00630/DSECTION=symptoms. |
McCormack, et al. Localization of the disulfide bond involved in post-translational processing of glycosylasparaginase and disrupted by a mutation in the Finnish-type aspartylglycosaminuria. J Biol Chem. Feb. 17, 1995;270(7):3212-5. |
Medsafe. Data sheet for alpha-lactose, Jul. 21, 1999, www.medsafe.govt.nz/Profs/Datasheet/a/Alphalactulosesyrup.htm. |
Melmed, et al. Metabolic markers and gastrointestinal symptoms in children with autism and related disorders. J Pediatr Gast Nutr. 2000; 31:S31-S32. |
Merck. Autism, Merck manual online medical library home addition, retrieved from the internet Mar. 10, 2008, www.mercl.corn/mmhge/sec23/ch286/ch286b.html. |
MeSH browser. "Child Development Disorders, Pervasive," and "Attention Deficit and Disruptive Behavior Disorders," National Library of medicine. 2001, www.nlm.nih.gov/mesh/2002/Mbrowser.html. |
Michell et al. Biomarkers and parkinson's disease. Brain. 2004; 127(8):1693-1705. |
Mitchell, et al. Comparative trial of viokase, pancreatin and Pancrease pancrelipase (enteric coated beads) in the treatment of malabsorption in cystic fibrosis. Aust Paediatr J. Jun. 1982;18(2):114-7. |
Mononen, et al. Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase. Proc Natl Acad Sci U S A. Apr. 1, 1991;88(7):2941-5. |
Munasinghe et al. Digestive enzyme supplementation for autism spectrum disorders: a double-blind randomized controlled trial. J Autism Dev Disord., 2010; 40(9):1131-1138 (abstract only). |
Nachaegari et al. Coprocessed excipients for solid dosage forms. Pharmaceutical Technology. 2004; p. 52, 54, 56 ,58, 60, 64. |
Neuer, et al. The role of heat shock proteins in reproduction. Hum Reprod Update. Mar.-Apr. 2000;6(2):149-59. |
Nevo et al. Acute immune polyneuropathies: correlations of serum antibodies to Campylobacter jejuni and Helicobacter pylori with anti-gm antibodies and clinical patterns of disease. J of Inf diseases. 1997; 175(S2):S154-6. |
Notice Non-Compliant Amendment dated Jun. 19, 2009 for U.S. Appl. No. 11/232,180. |
Notice Non-responsive Amendment dated Sep. 22, 2008 for U.S. Appl. No. 11/232,180. |
Notice of Allowance dated Apr. 15, 2011 for U.S. Appl. No. 12/487,868. |
Notice of Allowance dated Jun. 27, 2011 for U.S. Appl. No. 12/238,415. |
Notice of Allowance dated Jun. 28, 2011 for U.S. Appl. No. 12/487,868. |
Notice of Allowance dated Jun. 30, 2011 for U.S. Appl. No. 09/990,909. |
Notice of Allowance dated May 23, 2011 for U.S. Appl. No. 09/990,909. |
Notice of Non-Complaint Amendment dated Jun. 2, 2008 for U.S. Appl. No. 12/046,252. |
Notice of Non-Compliant Amendment dated Apr. 27, 2010 for U.S. Appl. No. 12/283,090. |
Notice of Non-Compliant Amendment dated May 7, 2007 for U.S. Appl. No. 11/213,255. |
Notice of Non-Responsive Amendment dated Feb. 11, 2008 for U.S. Appl. No. 11/555,697. |
Notice of Non-Responsive Amendment dated Sep. 25, 2008 for U.S. Appl. No. 11/555,697. |
Office Action dated Apr. 12, 2010 for U.S. Appl. No. 09/990,909. |
Office Action dated Apr. 21, 2008 for U.S. Appl. No. 11/232,180. |
Office Action dated Apr. 22, 2003 for U.S. Appl. No. 09/929,592. |
Office Action dated Apr. 27, 2011 for U.S. Appl. No. 10/681,018. |
Office Action dated Apr. 28, 2011, for U.S. Appl. No. 12/283,090. |
Office Action dated Aug. 13, 2002 for U.S. Appl. No. 09/929,592. |
Office Action dated Aug. 18, 2008 for U.S. Appl. No. 10/681,018. |
Office Action dated Aug. 18, 2010 for U.S. Appl. No. 10/681,018. |
Office Action dated Aug. 20, 2010 for U.S. Appl. No. 12/283,090. |
Office Action dated Aug. 25, 2010 for U.S. Appl. No. 12/487,868. |
Office Action dated Aug. 26, 2003 for U.S. Appl. No. 10/041,073. |
Office Action dated Aug. 3, 2009 for U.S. Appl. No. 11/555,697. |
Office Action dated Aug. 7, 2007 for U.S. Appl. No. 10/681,018. |
Office Action dated Aug. 8, 2007 for U.S. Appl. No. 11/213,382. |
Office Action dated Dec. 19, 2005 for U.S. Appl. No. 10/730,567. |
Office Action dated Dec. 22, 2006 for U.S. Appl. No. 10/681,018. |
Office Action dated Jan. 21, 2011 for U.S. Appl. No. 12/386,051. |
Office Action dated Jan. 29, 2002 for U.S. Appl. No. 09/707,395. |
Office Action dated Jan. 8, 2010 for U.S. Appl. No. 10/681,018. |
Office Action dated Jul. 22, 2010 for U.S. Appl. No. 12/049,613. |
Office Action dated Jul. 29, 2003 for U.S. Appl. No. 09/990,909. |
Office Action dated Jul. 30, 2002 for U.S. Appl. No. 09/707,395. |
Office Action dated Jul. 30, 2002 for U.S. Appl. No. 09/990,909. |
Office Action dated Jul. 6, 2010 for U.S. Appl. No. 11/533,818. |
Office action dated Jun. 29, 2011 for U.S. Appl. No. 11/555,697. |
Office Action dated Jun. 30, 2004 for U.S. Appl. No. 10/730,567. |
Office Action dated Mar. 18, 2008 for U.S. Appl. No. 11/468,379. |
Office Action dated Mar. 25, 2008 for U.S. Appl. No. 11/213,382. |
Office Action dated Mar. 28, 2008 for U.S. Appl. No. 11/555,697. |
Office Action dated Mar. 29, 2011 for U.S. Appl. No. 12/054,343. |
Office Action dated Mar. 30, 2011 for U.S. Appl. No. 12/786,739. |
Office Action dated May 22, 2002 for U.S. Appl. No. 09/466,559. |
Office Action dated May 24, 2011 for U.S. Appl. No. 12/487,864. |
Office Action dated Nov. 14, 2007 for U.S. Appl. No. 11/213,255. |
Office Action dated Nov. 15, 2010 for U.S. Appl. No. 12/238,415. |
Office Action dated Nov. 25, 2009 for U.S. Appl. No. 11/232,180. |
Office Action dated Nov. 26, 2001 for U.S. Appl. No. 09/466,559. |
Office Action dated Oct. 2, 2001 for U.S. Appl. No. 09/466,559. |
Office Action dated Sep. 22, 2004 for U.S. Appl. No. 10/730,567. |
Office Action dated Sep. 24, 2009 for U.S. Appl. No. 12/046,252. |
Pancreatic Enzyme Concentrate (PEC) Undiluted, Technical Data Sheet. 1 page, Scientific Protein Laboratories LLC Jun. 13, 2005. |
Pancreatin 4X USP, Technical Data Sheet, 1 page, Scientific Protein laboratories LLC Jun. 13, 2005. |
Parisi et al. Evaluation of new rapid commercial enzyme immunoassay for detection of crytosporidium oocysts in untreated stool specimens. J Clin Microbiol. 1995; 33(7):1963-1965. |
Perman et al. Role of ph in production of hydrogen from carbohydrates by colonic bacterial flora. J Clin Invest. 1981; 24(4):684-685. |
Peters et al. Prevalence of enteric parasites in homosexual patients attending an outpatient clinic. J of Clin Micro. 1986; 24(4):684-685. |
Preliminary Amendment dated May 18, 2009 for U.S. Appl. No. 12/046,252. |
Puri, et al. Isolated segmental duodenal ganglionosis. Indian Journal of Radiology and Imaging. 2000; 153-154. |
Remtulla et al. Stool chymotrypsin activity measured by a spectrophotometric procedure to identify pancreat disease in infants. Clinical Biochemistry. Dec. 1986; 19:341-342. |
Response dated Apr. 29, 2010 to Notice of Non-Compliant Amendment dated Apr. 27, 2010 for U.S. Appl. No. 12/283,090. |
Response dated Jun. 17, 2008 to Advisory Action dated Jun. 3, 2008 for U.S. Appl. No. 10/681,018. |
Response dated Jun. 24, 2002 to Restriction Requirement dated May 22, 2002 for U.S. Appl. No. 09/990,909. |
Response dated Jun. 7, 2007 to Notice of Non-Compliant Amendment dated May 7, 2007 for U.S. Appl. No. 11/213,255. |
Response dated Oct. 3, 2006 to Restriction Requirement dated Sep. 12, 2006 for U.S. Appl. No. 10/681,018. |
Restriction Requirement dated Apr. 23, 2003 for U.S. Appl. No. 09/990,909. |
Restriction Requirement dated Dec. 10, 2009 for U.S. Appl. No. 11/533,818. |
Restriction Requirement dated Jan. 10, 2008 for U.S. Appl. No. 11/232,180. |
Restriction Requirement dated Jan. 13, 2010 for U.S. Appl. No. 12/487,868. |
Restriction Requirement dated Jun. 22, 2007 for U.S. Appl. No. 11/213,255. |
Restriction Requirement dated May 22, 2002 for U.S. Appl. No. 09/990,909. |
Restriction Requirement dated May 9, 2007 for U.S. Appl. No. 11/213,382. |
Restriction Requirement dated Oct. 17, 2007 for U.S. Appl. No. 11/555,697. |
Restriction Requirement dated Oct. 7, 2009 for U.S. Appl. No. 12/283,090. |
Restriction Requirement dated Sep. 12, 2006 for U.S. Appl. No. 10/681,018. |
Rider, et al. Perspective of biochemical research in the neuronal ceroid-lipofuscinosis. Am J Med Genet. Feb. 15, 1992;42(4):519-24. (abstract only). |
Rogers. No more heartburn: Stop the pain in 30 days—naturally. 2000; 172. |
Rottier, et al. Lack of PPCA expression only partially coincides with lysosomal storage in galactosialidosis mice: indirect evidence for spatial requirement of the catalytic rather than the protective function of PPCA. Hum Mol Genet. Oct. 1998;7(11):1787-94. |
Sabra, et al. Linkage of ileal-lymphoid-nodular hyperplasia (ILNH), food allergy and CNS developmental: evidence for a non-IgE association. Ann Aller Asth Immunol. 1999; 82:8. |
Sandler et al. Short term benefit from oral vancomycin treatment of regressive-onset autism. J of Child Neuro. 2000; 15(7):42-435. |
Sandler, et al. Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. N Engl J Med. Dec. 9, 1999;341(24):1801-6. |
Schafer, et al. Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease. J Gastroenterol. 2000;35(1):1-9. (abstract only). |
Schiller. Review article: the therapy of constipation. Aliment Pharmacol Ther. 2001; 15:749-763 |
Schreck et al. Food preferences and factors influecing food selectivity for children with autism spectrum disorders. Res Develop Disabil, 2006; 27:353-363. |
Seneca et al. Enhancement of brain 1-dopa concetration with a-chymotrypsm. J American Geriatrics Society. 1973; 256-258. |
Sherwood et al. A new class of high-functionality excipients: silicified microcrystalline cellulose. Pharm Tech. 1998; 22(10):78-88. |
Singh, et al. Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism. J Neuroimmunol. May 1996;66(1-2):143-5. |
Skeels et al. Crytosporidium infection in Oregon public health clinic patients 1985-88: the value of statewide laboratory surveillance. AJPH. 1990; 80(3):305-308. |
Stein, et al. Nitrogen Metabolism in normal and hyperkinetic boys. Am J Clin Nutr. 1984; 39:520-524. |
Stein, et al. Nitrogen metabolism in normal and hyperkinetic boys. Am J Clin Nutr. Apr. 1984;39(4):520-4. |
Steinherz, et al. Patterns of amino acid efflux from isolated normal and cystinotic human leucocyte lysosomes. J Biol Chem. Jun. 10, 1982;257(11):6041-9. (abstract only). |
Stoll, et al. Enteral nutrient intake level determines intestinal protein synthesis and accretion rates in neonatal pigs. Am J Physiol Gastrointest Liver Physiol. Aug. 2000;279(2):G288-94. |
Strader, et al. Publication Structural basis of β-adrenergic receptor function. FASEB J. May 1989;3(7):1825-32. |
Sturmey. Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials. Res Dev Disabil. Jan.-Feb. 2005;26(1):87-97. |
Supplemental Amendment and Response dated Jun. 8, 2010 to Restriction Requirement dated Oct. 7, 2009 for U.S. Appl. No. 12/283,090. |
The Alzheimer's Association. Basics of Alzheimer's Disease. 2005, www.alz.org/national/documents/brochure—Basicsofalz—low/pdf. |
Thomas, et al. Defective protein folding as a basis of human disease. Trends Biochem Sci. Nov. 1995;20(11):456-9. |
Tsang et al. Extragastroduodenal conditions associated with Heliobacter pylori infection. Hong Kong Medical Journal, 1999; 5(2):169-174. |
U.S. Appl. No. 13/002,136, filed Dec. 30, 2010, Fallon. |
USP (32)-NF(27) 2009, Pancreatin, V.3, pp. 3194-3195. |
Vilanova, et al. Preparative isolation of the two forms of pig pancreatic pro-(carboxypeptidase A) and their monomeric carboxypeptidases A. Biochem J. Aug. 1, 1985;229(3):605-9. |
Volkmar, et al. Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders. American Academy of Child and Adolescent Psychiatry Working Group on Quality Issues. J Am Acad Child Adolesc Psychiatry. (PART 1) Dec. 1999;38(12 Suppl):32S-54S. |
Volkmar, et al. Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults with Autism and other Pervasive Developmental Disorders. American Academy of Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry. (PART 2) Dec. 1999;38(12):1611-6. |
Wakefield, et al. Enterocolitis in children with developmental disorders. Am J Gastroenterol. Sep. 2000;95(9):2285-95. |
Wakefield, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. Feb. 28, 1998;351(9103):637-41. |
Walsh, et al. Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development. Cell Mol Life Sci. Feb. 1997;53(2):198-211. |
Weintraub, et al. Morphometric studies of pancreatic acinar granule formation in NCTR-Balb/c mice, J Cell Sci. May 1992;102 (Pt 1):141-7. |
Wender et al. Prevalence of attention deficit disorder, residual type, and other psychiatric disorders in patients with irritable colon syndrome. Am J Psychiatry. 1983; 140(12):1579-82 Abstract only. |
Williams, et al. Eating habits of children with autism. Pediatr Nurs. May-Jun. 2000;26(3):259-64. |
Wohlman et al. Enhancement of drug activity by chymotrypsin, penicillin penetration into granulomatous sesions and inflammatory fluids. Cellular and Molecular Life Sciences. 1969; 25(9):953-954. |
Woodward et al. Ischaemic enterocolitis complicating aidiopathic dysatuonomia. Gut. 1998; 43:285-287. |
Youngberg, et al. Comparison of gastrointestinal pH in cystic fibrosis and healthy subjects. Dig Dis Sci. May 1987;32(5):472-80. |
Yuan, et al.. Freeze-Thaw Stability of Three Waxy Maize Starch Pastes Measured by Centrifugation and Calorimetry. Cereal Chem. 1998; 75(4):571-573. |
Zeiner, et al. Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO J. Sep. 15, 1997;16(18):5483-90. |
Zhang et al. Lactulose-mannitol intestinal permeability test in children with diarrhea caused by rotavirus abd Cryptosporidium. J of Pediatric Gastro & Nutrition. 2000; 31(1):16-21. |
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US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
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US20060182728A1 (en) | 2006-08-17 |
US6632429B1 (en) | 2003-10-14 |
US8613918B2 (en) | 2013-12-24 |
US20090197289A1 (en) | 2009-08-06 |
US8815233B2 (en) | 2014-08-26 |
US20120230970A1 (en) | 2012-09-13 |
US20120114626A1 (en) | 2012-05-10 |
US20060183180A1 (en) | 2006-08-17 |
US8105584B2 (en) | 2012-01-31 |
US8008036B2 (en) | 2011-08-30 |
US20090130081A1 (en) | 2009-05-21 |
AU3263901A (en) | 2001-06-25 |
WO2001043764A2 (en) | 2001-06-21 |
US20180296650A1 (en) | 2018-10-18 |
US8211661B2 (en) | 2012-07-03 |
US9624526B2 (en) | 2017-04-18 |
US20040071683A1 (en) | 2004-04-15 |
US20080219966A1 (en) | 2008-09-11 |
US20120207740A1 (en) | 2012-08-16 |
US9624525B2 (en) | 2017-04-18 |
US20120114562A1 (en) | 2012-05-10 |
WO2001043764A3 (en) | 2001-11-29 |
US20170157221A1 (en) | 2017-06-08 |
US8163278B2 (en) | 2012-04-24 |
US20090286270A1 (en) | 2009-11-19 |
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