US20070238759A1 - Novel Polymorph V of Torasemide - Google Patents
Novel Polymorph V of Torasemide Download PDFInfo
- Publication number
- US20070238759A1 US20070238759A1 US11/763,156 US76315607A US2007238759A1 US 20070238759 A1 US20070238759 A1 US 20070238759A1 US 76315607 A US76315607 A US 76315607A US 2007238759 A1 US2007238759 A1 US 2007238759A1
- Authority
- US
- United States
- Prior art keywords
- torasemide
- polymorph
- pharmaceutical form
- form according
- novel polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 title claims abstract description 140
- 229960005461 torasemide Drugs 0.000 title claims abstract description 138
- 238000000034 method Methods 0.000 claims abstract description 42
- 230000004048 modification Effects 0.000 claims abstract description 42
- 238000012986 modification Methods 0.000 claims abstract description 42
- 230000008569 process Effects 0.000 claims abstract description 37
- 238000002360 preparation method Methods 0.000 claims abstract description 30
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 206010006451 bronchitis Diseases 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 208000028867 ischemia Diseases 0.000 claims description 6
- 239000002934 diuretic Substances 0.000 claims description 5
- 230000001882 diuretic effect Effects 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 claims description 4
- 206010002383 Angina Pectoris Diseases 0.000 claims description 3
- 208000012904 Bartter disease Diseases 0.000 claims description 3
- 208000010062 Bartter syndrome Diseases 0.000 claims description 3
- 206010048962 Brain oedema Diseases 0.000 claims description 3
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 3
- 206010010254 Concussion Diseases 0.000 claims description 3
- 208000016998 Conn syndrome Diseases 0.000 claims description 3
- 208000010412 Glaucoma Diseases 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 206010027476 Metastases Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 206010037423 Pulmonary oedema Diseases 0.000 claims description 3
- 206010039808 Secondary aldosteronism Diseases 0.000 claims description 3
- 208000007536 Thrombosis Diseases 0.000 claims description 3
- 230000005856 abnormality Effects 0.000 claims description 3
- 230000001154 acute effect Effects 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 239000013566 allergen Substances 0.000 claims description 3
- 208000006673 asthma Diseases 0.000 claims description 3
- 210000004556 brain Anatomy 0.000 claims description 3
- 208000006752 brain edema Diseases 0.000 claims description 3
- 208000007451 chronic bronchitis Diseases 0.000 claims description 3
- 230000009514 concussion Effects 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 230000001037 epileptic effect Effects 0.000 claims description 3
- 210000005003 heart tissue Anatomy 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 208000014674 injury Diseases 0.000 claims description 3
- 230000004410 intraocular pressure Effects 0.000 claims description 3
- 230000002503 metabolic effect Effects 0.000 claims description 3
- 208000013846 primary aldosteronism Diseases 0.000 claims description 3
- 208000005333 pulmonary edema Diseases 0.000 claims description 3
- 230000000451 tissue damage Effects 0.000 claims description 3
- 231100000827 tissue damage Toxicity 0.000 claims description 3
- 230000008733 trauma Effects 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 230000000181 anti-adherent effect Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 235000019426 modified starch Nutrition 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 description 45
- 239000013078 crystal Substances 0.000 description 28
- 238000002329 infrared spectrum Methods 0.000 description 26
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 24
- 239000007864 aqueous solution Substances 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 238000001914 filtration Methods 0.000 description 12
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 230000020477 pH reduction Effects 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000000113 differential scanning calorimetry Methods 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000004566 IR spectroscopy Methods 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- -1 hydrochloric Chemical class 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- UJEWTUDSLQGTOA-UHFFFAOYSA-N Piretanide Chemical compound C=1C=CC=CC=1OC=1C(S(=O)(=O)N)=CC(C(O)=O)=CC=1N1CCCC1 UJEWTUDSLQGTOA-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- YAXMCEWRTZAGIM-DSTWUDMISA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(E)-(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate hydrochloride Chemical compound Cl.CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(\C=N\N4CCN(CC4)C4CCCC4)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C YAXMCEWRTZAGIM-DSTWUDMISA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- IIOPLILENRZKRV-UHFFFAOYSA-N azosemide Chemical compound C=1C=CSC=1CNC=1C=C(Cl)C(S(=O)(=O)N)=CC=1C1=NN=N[N]1 IIOPLILENRZKRV-UHFFFAOYSA-N 0.000 description 1
- 229960004988 azosemide Drugs 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229960004064 bumetanide Drugs 0.000 description 1
- MAEIEVLCKWDQJH-UHFFFAOYSA-N bumetanide Chemical compound CCCCNC1=CC(C(O)=O)=CC(S(N)(=O)=O)=C1OC1=CC=CC=C1 MAEIEVLCKWDQJH-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000012822 chemical development Methods 0.000 description 1
- 238000001938 differential scanning calorimetry curve Methods 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 230000008863 intramolecular interaction Effects 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 239000002171 loop diuretic Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 1
- 229960005017 olanzapine Drugs 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000005489 p-toluenesulfonic acid group Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229960001085 piretanide Drugs 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229960001203 stavudine Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Definitions
- the present invention relates to a novel crystalline form of N-(1-methylethyl aminocarbonyl)-4(3-methyl-phenylamino)-3-pyridinesulfonamide (further referred to by its generic name “torasemide”), especially to a novel polymorph V of torasemide, to a process for its preparation, to its use as a raw material for the preparation of crystalline modifications I and III of torasemide, to amorphous torasemide modifications and to pharmaceutically acceptable salts of torasemide, to pharmaceutical forms containing the said novel polymorph V of torasemide as the active ingredient as well as to its use.
- torasemide N-(1-methylethyl aminocarbonyl)-4(3-methyl-phenylamino)-3-pyridinesulfonamide
- Torasemide is a new potent diuretic in the class of the so-called “loop diuretics”, which is described in DE patent 25 16 025 Sample 71). Structurally, it entirely differs from diuretics of the same class such as furosemide, bumetanide and azosemide. In addition to diuretic properties it also possesses antihypertensive properties.
- a diuretic of Henle's loop it is useful as an agent for preventing heart or heart tissue damages caused by metabolic or ionic abnormalities associated with ischemia, in the treatment of thrombosis, angina pectoris, asthma, hypertension, nephroedema, pulmonary edema, primary and secondary aldosteronism, Bartter's syndrome, tumours, glaucoma, decreasing of intraocular pressure, acute or chronic bronchitis, in the treatment of cerebral edema caused by trauma, ischemia, concussion of the brain, metastases or epileptic attacks and in the treatment of nasal infections caused by allergens.
- polymorphism The ability of a substance to exist in more than one crystalline form is defined as polymorphism and these different crystalline forms are named “polymorph modifications” or “polymorphs”.
- polymorphism is caused by the ability of the molecule of a substance to change its conformation or to form different inter-molecular and intramolecular interactions, particularly hydrogen bonds, which is reflected in different atom arrangements in the crystal lattices of different polymorphs.
- Polymorphism is found in several organic compounds. Among medicaments polymorphism is found in about 70% of barbiturates, 60% of sulfonamides and 60% of steroids, and about 50% of medicaments of the said classes are not present on the market in their most stable forms (T. Laird, Chemical Development and Scale-up in the Fine Chemical Industry, Principles and Practices, Course Manual, Scientific Update, Wyvern Cottage, 1996).
- the different polymorphs of a substance possess different energies of the crystal lattice and, thus, they show different physical properties of the solid state such as form, density, melting point, colour, stability, dissolution rate, milling facility, granulation, compacting etc., which in medicaments may affect the possibility of the preparation of pharmaceutical forms, their stability, dissolution and bioavailability and, consequently, their action.
- Polymorphism of medicaments is the object of studies of interdisciplinary expert teams [J. Haleblian, W. McCrone, J. Pharm. Sci. 58 (1969) 911; L. Borka, Pharm. Acta Helv. 66 (1991) 16; M. Kuhnert-Brand Toor, Pharmazie 51 (1996) 443; H. G. Brittain, J. Pharm. Sci. 86 (1997) 405; W. H. Streng, DDT 2 (1997) 415; K. Yoshii, Chem. Pharm. Bull. 45 (1997) 338, etc.].
- a good knowledge of polymorphism represents a precondition for a critical observation of the whole process of medicament development.
- torasemide can exist in three crystalline modifications differing with regard to the parameters of a unit cell, which is confirmed by X-ray diffraction on their monocrystals, and in one amorphous modification (HR patent application P20000162A).
- Modification I with melting point 169° C. [ Acta Cryst . B34 (1978), 1304-1310] and modification III with melting point 165° C. (WO 00/20395) crystallize monoclinically in the space group P 2 1 /n (prisms), while modification II with melting point 162° C. crystallizes monoclinically in the space group P 2/n (foils) [ Acta Cryst . B34 (1978), 2659-2662].
- U.S. Pat. No. 5,914,336 protected the use of a new torasemide polymorph, however, only some of its physical-chemical properties such as melting point, heat of formation, solubility, first band in IR-spectum, but no X-ray patterns of the powder and monocrystals were stated therein. Since the data as stated are not relevant for the characterization of polymorphism, the claimed subject-matter of U.S. Pat. No. 5,914,336 is not believed to be reliable.
- novel polymorph V of torasemide is prepared according to the inventive process in the form of a flowable crystalline powder having the property of flowability, i.e. it is obtained in a “free-flow” form which is statically not chargeable.
- DSC of the novel polymorph V of torasemide shows one exothermic maximum at about 157.59° C. (onset at about 150.74° C.) (heating rate of 10° C./min) resulting from decomposition (also evident on the basis of IR spectroscopy and thin-layer chromatography).
- the X-ray powder pattern of the novel polymorph V of torasemide differs from the X-ray powder patterns of the known torasemide modifications ( FIG. 2 ).
- the IR spectrum of a sample of the novel polymorph V of torasemide recorded in KBr differs from IR spectra of the known torasemide modifications.
- the novel polymorph V of torasemide shows characteristic absorption bands at 2671 to 3327 cm ⁇ 1 and at 1468 to 1705 cm ⁇ 1 .
- FIG. 1 represents a characteristic thermogram of differential scanning calorimetry (DSC) of the novel polymorph V of torasemide.
- FIG. 2 represents a characteristic X-ray powder pattern of the novel polymorph V of torasemide.
- FIG. 3 represents a characteristic IR spectrum of the novel polymorph V of torasemide recorded in KBr.
- novel polymorph V of torasemide according to the present invention can be obtained by a rapid acidification of alkaline torasemide solutions with inorganic or organic acids.
- a process for the preparation of the novel polymorph V of torasemide comprises:
- a process for the preparation of the novel polymorph V of torasemide also comprises:
- a process for the preparation of the novel polymorph V of torasemide also comprises:
- a process for the preparation of the novel polymorph V of torasemide also comprises:
- a process for the preparation of the novel polymorph V of torasemide also comprises:
- a process for the preparation of the novel polymorph V of torasemide also comprises:
- aqueous solutions of lithium hydroxide, sodium hydroxide and potassium hydroxide as well as aqueous solutions of sodium carbonate and potassium carbonate may be used for the preparation of alkaline solutions of torasemide modifications.
- alkaline torasemide solutions may, according to the present process, be carried out with inorganic acids such as hydrochloric, sulfuric, phosphoric and nitric acids, and with organic acids such as formic, acetic, propionic, oxalic, tartaric, methanesulfonic and p-toluenesulfonic acids.
- inorganic acids such as hydrochloric, sulfuric, phosphoric and nitric acids
- organic acids such as formic, acetic, propionic, oxalic, tartaric, methanesulfonic and p-toluenesulfonic acids.
- novel polymorph V of torasemide prepared according to the present process may be converted to crystalline modifications I, II or III of torasemide or to an amorphous torasemide modification according to conventional processes, i.e. it may serve as a starting material for the preparation of well-known crystalline modifications I, II or III of torasemide or an amorphous torasemide modification.
- novel polymorph V of torasemide prepared according to the present invention may be converted into pharmaceutically acceptable salts of torasemide in a well-known manner.
- the novel polymorph V of torasemide prepared according to the present process may be, as a suitable torasemide form, used as a diuretic or as an agent for preventing heart or heart tissue damages caused by metabolic or ionic abnormalities associated with ischemia, in the treatment of thrombosis, angina pectoris, asthma, hypertension, nephroedema, pulmonary edema, primary and secondary aldosteronism, Bartter's syndrome, tumours, glaucoma, decreasing of intraocular pressure, acute or chronic bronchitis, in the treatment of cerebral edema caused by trauma, ischemia, concussion of the brain, metastases or epileptic attacks and in the treatment of nasal infections caused by allergens.
- the present invention also relates to pharmaceutical forms such as tablets, capsules or injections containing an effective amount of the novel polymorph V of torasemide as an active ingredient, without or in combination with one or more pharmaceutically acceptable additives such as sugar, starch, starch derivatives, cellulose, cellulose derivatives, mould release agents, and antiadhesive agents and, possibly, agents for regulating flowability.
- pharmaceutically acceptable additives such as sugar, starch, starch derivatives, cellulose, cellulose derivatives, mould release agents, and antiadhesive agents and, possibly, agents for regulating flowability.
- the crystalline modification I of torasemide (1.0 g) prepared according to Acta Cryst . B34 (1978) 1304-1310, was dissolved in a 5% aqueous sodium hydroxide solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 5% aqueous hydrochloric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- the characteristic DSC curve of the sample as shown in FIG. 1 was recorded on the apparatus Perkin-Elmer DSC7 at a heating rate of 10° C./minute.
- the characteristic IR spectrum of the sample as shown in FIG. 3 was recorded in KBr on the IR-spectrophotometer Nicolet-Magna 760.
- the crystalline modification II of torasemide (1.0 g) prepared according to Acta Cryst . B34 (1978) 1304-1310, was dissolved in a 5% aqueous potassium hydroxide solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 10% aqueous acetic acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the crystalline modification III of torasemide (10.0 g) prepared according to WO 00/20395, was dissolved in a 10% aqueous sodium carbonate solution (30 ml) and then at the temperature of 20° C. the solution was acidified for 60 seconds with a 5% aqueous sulfuric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (8.1 g), m.p. 153-155° C. was obtained.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the novel polymorph V of torasemide (10.0 g) according to Example 3 of the present invention was dissolved in a 5% aqueous lithium hydroxide solution (30 ml) and then at the temperature of 20° C. the solution was acidified for 120 seconds with a 5% aqueous phosphoric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (7.9 g), m.p. 153-155° C. was obtained.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- the novel polymorph V of torasemide obtained according to Example 1 of the present invention was subjected to testing the release of the active substance in water at the temperature of 37° C. (USP 24) and the results are given in Table 1.
- TABLE 1 Release of the novel polymorph V of torasemide in water (USP 24) (37° C., 50 rpm, 1000 ml) Time Released torasemide (min) (%) 0 0 15 11.3 30 20.5 45 26.0 60 30.0 90 36.0 120 40.7
Abstract
The invention relates to a novel polymorph V of torasemide, to a process for its preparation, to its use as a raw material for the preparation of crystalline modifications I and III of torasemide, to amorphous torasemide modifications and to pharmaceutically acceptable salts of torasemide, to pharmaceutical forms containing the said novel polymorph V of torasemide as the active ingredient as well as to its use.
Description
- The present invention relates to a novel crystalline form of N-(1-methylethyl aminocarbonyl)-4(3-methyl-phenylamino)-3-pyridinesulfonamide (further referred to by its generic name “torasemide”), especially to a novel polymorph V of torasemide, to a process for its preparation, to its use as a raw material for the preparation of crystalline modifications I and III of torasemide, to amorphous torasemide modifications and to pharmaceutically acceptable salts of torasemide, to pharmaceutical forms containing the said novel polymorph V of torasemide as the active ingredient as well as to its use.
- Torasemide is a new potent diuretic in the class of the so-called “loop diuretics”, which is described in
DE patent 25 16 025 Sample 71). Structurally, it entirely differs from diuretics of the same class such as furosemide, bumetanide and azosemide. In addition to diuretic properties it also possesses antihypertensive properties. - As a diuretic of Henle's loop it is useful as an agent for preventing heart or heart tissue damages caused by metabolic or ionic abnormalities associated with ischemia, in the treatment of thrombosis, angina pectoris, asthma, hypertension, nephroedema, pulmonary edema, primary and secondary aldosteronism, Bartter's syndrome, tumours, glaucoma, decreasing of intraocular pressure, acute or chronic bronchitis, in the treatment of cerebral edema caused by trauma, ischemia, concussion of the brain, metastases or epileptic attacks and in the treatment of nasal infections caused by allergens.
- The ability of a substance to exist in more than one crystalline form is defined as polymorphism and these different crystalline forms are named “polymorph modifications” or “polymorphs”. In general, polymorphism is caused by the ability of the molecule of a substance to change its conformation or to form different inter-molecular and intramolecular interactions, particularly hydrogen bonds, which is reflected in different atom arrangements in the crystal lattices of different polymorphs. Polymorphism is found in several organic compounds. Among medicaments polymorphism is found in about 70% of barbiturates, 60% of sulfonamides and 60% of steroids, and about 50% of medicaments of the said classes are not present on the market in their most stable forms (T. Laird, Chemical Development and Scale-up in the Fine Chemical Industry, Principles and Practices, Course Manual, Scientific Update, Wyvern Cottage, 1996).
- The different polymorphs of a substance possess different energies of the crystal lattice and, thus, they show different physical properties of the solid state such as form, density, melting point, colour, stability, dissolution rate, milling facility, granulation, compacting etc., which in medicaments may affect the possibility of the preparation of pharmaceutical forms, their stability, dissolution and bioavailability and, consequently, their action.
- Polymorphism of medicaments is the object of studies of interdisciplinary expert teams [J. Haleblian, W. McCrone, J. Pharm. Sci. 58 (1969) 911; L. Borka, Pharm. Acta Helv. 66 (1991) 16; M. Kuhnert-Brandstätter, Pharmazie 51 (1996) 443; H. G. Brittain, J. Pharm. Sci. 86 (1997) 405; W. H. Streng, DDT 2 (1997) 415; K. Yoshii, Chem. Pharm. Bull. 45 (1997) 338, etc.]. A good knowledge of polymorphism represents a precondition for a critical observation of the whole process of medicament development. Thus, at deciding on the production of a pharmaceutical form in solid state and with regard to the dose size, stability, dissolution and anticipated action, it is necessary to determine the existence of all solid state forms (on the market some computer programmes can be found, e.g. Polymorph as a module of Cerius2 programme, MSI Inc., USA) and to determine the physical-chemical properties of each of them. Only on the basis of these determinations the appropriate polymorph can be selected for the development of pharmaceutical formulations of desired properties.
- From the great number of such efforts only a few will be mentioned as an example. Thus, Gordon et al. (U.S. Pat. No. 4,476,248) protected a novel crystalline form of ibuprofen and a process for the preparation thereof. Bunnel et al. (EP 733,635) protected a novel crystalline form, a process for the preparation thereof and pharmaceutical formulations of the drug olanzapine containing the said novel form. R. B. Gandhi et al. (EP 749,969) protected a novel process for the preparation of a polymorphous form I of stavudine from a mixture of one or more forms I, II and III, whereas A. Caron et al. (EP 708,103) protected a novel crystalline form of irbesartane, a process for the preparation thereof as well as pharmaceutical formulations containing this crystalline form. Chikaraishi et al. (WO 9626197) protected, in addition to a polymorphous form, also an amorphous form of piretanide as well as processes for the preparation thereof. J.-B. Cha et al. (WO 9857967) protected an amorphous form, a process for the preparation thereof and pharmaceutical formulations of the medicament itraconazole containing this amorphous form, whereas E. Occeli et al. (WO 90/00553) protected crystal polymorphs I and II and amorphs of the medicament rifapentine hydrochloride and hydrobromide. Further, for the new antidiabetic troglitazone G. Om Reddy et al. (U.S. Pat. No. 5,700,820) protected six polymorphs: five crystal polymorphs and one amorphous one.
- It is known that torasemide can exist in three crystalline modifications differing with regard to the parameters of a unit cell, which is confirmed by X-ray diffraction on their monocrystals, and in one amorphous modification (HR patent application P20000162A). Modification I with melting point 169° C. [Acta Cryst. B34 (1978), 1304-1310] and modification III with melting point 165° C. (WO 00/20395) crystallize monoclinically in the
space group P 21/n (prisms), while modification II with melting point 162° C. crystallizes monoclinically in thespace group P 2/n (foils) [Acta Cryst. B34 (1978), 2659-2662]. - In addition to the above, U.S. Pat. No. 5,914,336 protected the use of a new torasemide polymorph, however, only some of its physical-chemical properties such as melting point, heat of formation, solubility, first band in IR-spectum, but no X-ray patterns of the powder and monocrystals were stated therein. Since the data as stated are not relevant for the characterization of polymorphism, the claimed subject-matter of U.S. Pat. No. 5,914,336 is not believed to be reliable.
- In our further research in the field of torasemide we have surprisingly found a novel crystalline torasemide modification, i.e. a novel polymorph V of torasemide which has hitherto not been known.
- The novel polymorph V of torasemide is prepared according to the inventive process in the form of a flowable crystalline powder having the property of flowability, i.e. it is obtained in a “free-flow” form which is statically not chargeable.
- In a solution the novel polymorph V of torasemide is identical to other known torasemide modifications, which is evident from NMR and UV spectra. On the other hand, solid state analysis techniques such as differential scanning calorimetry (DSC), X-ray powder pattern (XRD) and IR spectroscopy reveal a difference in comparison to the known torasemide modifications.
- DSC of the novel polymorph V of torasemide (
FIG. 1 ) shows one exothermic maximum at about 157.59° C. (onset at about 150.74° C.) (heating rate of 10° C./min) resulting from decomposition (also evident on the basis of IR spectroscopy and thin-layer chromatography). - The X-ray powder pattern of the novel polymorph V of torasemide differs from the X-ray powder patterns of the known torasemide modifications (
FIG. 2 ). - The IR spectrum of a sample of the novel polymorph V of torasemide recorded in KBr (
FIG. 3 ) differs from IR spectra of the known torasemide modifications. The novel polymorph V of torasemide shows characteristic absorption bands at 2671 to 3327 cm−1 and at 1468 to 1705 cm−1. -
FIG. 1 represents a characteristic thermogram of differential scanning calorimetry (DSC) of the novel polymorph V of torasemide. -
FIG. 2 represents a characteristic X-ray powder pattern of the novel polymorph V of torasemide. -
FIG. 3 represents a characteristic IR spectrum of the novel polymorph V of torasemide recorded in KBr. - The novel polymorph V of torasemide according to the present invention can be obtained by a rapid acidification of alkaline torasemide solutions with inorganic or organic acids.
- A process for the preparation of the novel polymorph V of torasemide comprises:
- (i) the preparation of a polymorph I of torasemide according to a known process,
- (ii) the dissolution of the polymorph I of torasemide in an aqueous solution of a base,
- (iii) the filtration of the obtained solution,
- (iv) a rapid acidification of the obtained solution with an aqueous solution of an acid at temperatures between 0° C. and 35° C.,
- (v) the filtration of the obtained suspension,
- (vi) washing the thus obtained crystals of the novel polymorph V of torasemide with demineralized water and drying them in a vacuum dryer during 3 hours at 50° C., the obtained crystals being characterized by the following data:
- DSC: exothermic maximum at about 157.59° C. (onset at about 150.74° C.) (
FIG. 1 ); - X-ray powder pattern (2Θ): 5.610; 6.130; 7.480; 7.970; 9.310; 9.615; 10.835; 11.020; 12.340; 13.075; 13.460; 13.920; 14.200; 15.090; 16.080; 16.710; 17.445; 17.720; 18.460; 18.850; 19.825; 20.340; 20.990; 21.980; 22.075; 22.630; 22.935; 23.410; 23.845; 24.880; 25.560; 26.035; 27.285; 27.540; 28.170; 28.645; 29.350; 29.975; 30.575; 31.265; 32.300; 34.050; 35.650; 36.375; 37.100, and 38.145 (
FIG. 2 ); - IR-characteristic absorption bands (cm−1): at 2671 to 3327 and at 1468 to 1705 (
FIG. 3 ).
- DSC: exothermic maximum at about 157.59° C. (onset at about 150.74° C.) (
- According to a further embodiment of the present invention, a process for the preparation of the novel polymorph V of torasemide also comprises:
- (i) the preparation of a polymorph II of torasemide according to a known process,
- (ii) the dissolution of the polymorph II of torasemide in an aqueous solution of a base,
- (iii) the filtration of the obtained solution,
- (iv) a rapid acidification of the obtained solution with an aqueous solution of an acid at temperatures between 0° C. and 35° C.,
- (v) the filtration of the obtained suspension,
- (vi) washing the thus obtained crystals of the novel polymorph V of torasemide with demineralized water and drying them in a vacuum dryer during 3 hours at 50° C., the obtained crystals being characterized by the data represented in the previous process.
- According to a further embodiment of the present invention, a process for the preparation of the novel polymorph V of torasemide also comprises:
- (i) the preparation of a polymorph III of torasemide according to a known process,
- (ii) the dissolution of the polymorph III of torasemide in an aqueous solution of a base,
- (iii) the filtration of the obtained solution,
- (iv) a rapid acidification of the obtained solution with an aqueous solution of an acid at temperatures between 0° C. and 35° C.,
- (v) the filtration of the obtained suspension,
- (vi) washing the thus obtained crystals of the novel polymorph V of torasemide with demineralized water and drying them in a vacuum dryer during 3 hours at 50° C., the obtained crystals being characterized by the data represented in the previous process.
- According to a further embodiment of the present invention, a process for the preparation of the novel polymorph V of torasemide also comprises:
- (i) the preparation of an amorphous torasemide modification according to a known process,
- (ii) the dissolution of the amorphous torasemide modification in an aqueous solution of a base,
- (iii) the filtration of the obtained solution,
- (iv) a rapid acidification of the obtained solution with an aqueous solution of an acid at temperatures between 0° C. and 35° C.,
- (v) the filtration of the obtained suspension,
- (vi) washing the thus obtained crystals of the novel polymorph V of torasemide with demineralized water and drying them in a vacuum dryer during 3 hours at 50° C., the obtained crystals being characterized by the data represented in the previous process.
- According to a further embodiment of the present invention, a process for the preparation of the novel polymorph V of torasemide also comprises:
- (i) the preparation of a novel polymorph V of torasemide according to the process of the present invention,
- (ii) the dissolution of the novel polymorph V of torasemide in an aqueous solution of a base,
- (iii) the filtration of the obtained solution,
- (iv) a rapid acidification of the obtained solution with an aqueous solution of an acid at temperatures between 0° C. and 35° C.,
- (v) the filtration of the obtained suspension,
- (vi) washing the thus obtained crystals of the novel polymorph V of torasemide with demineralized water and drying them in a vacuum dryer during 3 hours at 50° C., the obtained crystals being characterized by the data represented in the previous process.
- According to a further embodiment of the present invention, a process for the preparation of the novel polymorph V of torasemide also comprises:
- (i) the preparation of polymorphs I, II and III of torasemide according to known processes, the preparation of an amorphous torasemide modification according to a known process and the preparation of the novel polymorph V of torasemide according to the process of the present invention,
- (ii) the dissolution of any mixture of the polymorphs I, II and III of torasemide, of the amorphous torasemide modification or the novel polymorph V of torasemide in an aqueous solution of a base,
- (iii) the filtration of the obtained solution,
- (iv) a rapid acidification of the obtained solution with an aqueous solution of an acid at temperatures between 0° C. and 35° C.,
- (v) the filtration of the obtained suspension,
- (vi) washing the thus obtained crystals of the novel polymorph V of torasemide with demineralized water and drying them in a vacuum dryer during 3 hours at 50° C., the obtained crystals being characterized by the data represented in the previous process.
- According to the present process, aqueous solutions of lithium hydroxide, sodium hydroxide and potassium hydroxide as well as aqueous solutions of sodium carbonate and potassium carbonate may be used for the preparation of alkaline solutions of torasemide modifications.
- The acidification of alkaline torasemide solutions may, according to the present process, be carried out with inorganic acids such as hydrochloric, sulfuric, phosphoric and nitric acids, and with organic acids such as formic, acetic, propionic, oxalic, tartaric, methanesulfonic and p-toluenesulfonic acids.
- It has also been established that at using the present process no decomposition of torasemide takes place, i.e. a chemically pure novel polymorph V of torasemide (TLC and HPLC) is obtained.
- It has been additionally established that under normal storage conditions the novel polymorph V of torasemide is stable at milling and pressing, i.e. it is not transformed into crystalline modifications I, II and III of torasemide or into an amorphous torasemide modification.
- The novel polymorph V of torasemide prepared according to the present process may be converted to crystalline modifications I, II or III of torasemide or to an amorphous torasemide modification according to conventional processes, i.e. it may serve as a starting material for the preparation of well-known crystalline modifications I, II or III of torasemide or an amorphous torasemide modification.
- The novel polymorph V of torasemide prepared according to the present invention may be converted into pharmaceutically acceptable salts of torasemide in a well-known manner.
- The examination of the release (USP 24) of the novel polymorph V of torasemide in water in comparison with the release profile of known crystalline torasemide modifications in the same medium revealed a slower release thereof. This makes the novel polymorph V of torasemide suitable for the preparation of pharmaceutical preparations having immediate or prolonged action.
- The novel polymorph V of torasemide prepared according to the present process may be, as a suitable torasemide form, used as a diuretic or as an agent for preventing heart or heart tissue damages caused by metabolic or ionic abnormalities associated with ischemia, in the treatment of thrombosis, angina pectoris, asthma, hypertension, nephroedema, pulmonary edema, primary and secondary aldosteronism, Bartter's syndrome, tumours, glaucoma, decreasing of intraocular pressure, acute or chronic bronchitis, in the treatment of cerebral edema caused by trauma, ischemia, concussion of the brain, metastases or epileptic attacks and in the treatment of nasal infections caused by allergens.
- The present invention also relates to pharmaceutical forms such as tablets, capsules or injections containing an effective amount of the novel polymorph V of torasemide as an active ingredient, without or in combination with one or more pharmaceutically acceptable additives such as sugar, starch, starch derivatives, cellulose, cellulose derivatives, mould release agents, and antiadhesive agents and, possibly, agents for regulating flowability.
- The present invention is illustrated by the following non-limiting Examples.
- The crystalline modification I of torasemide (1.0 g) prepared according to Acta Cryst. B34 (1978) 1304-1310, was dissolved in a 5% aqueous sodium hydroxide solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 5% aqueous hydrochloric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The characteristic DSC curve of the sample as shown in
FIG. 1 was recorded on the apparatus Perkin-Elmer DSC7 at a heating rate of 10° C./minute. - The characteristic X-ray powder pattern as shown in
FIG. 2 was recorded on the instrument PHILIPS PW3710 under Cu X-rays [λ(CuKα1)=1.54046 Å and λ(CuKα2)=1.54439 Å]. - The characteristic IR spectrum of the sample as shown in
FIG. 3 was recorded in KBr on the IR-spectrophotometer Nicolet-Magna 760. - The crystalline modification II of torasemide (1.0 g) prepared according to Acta Cryst. B34 (1978) 1304-1310, was dissolved in a 5% aqueous potassium hydroxide solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 10% aqueous acetic acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- The crystalline modification III of torasemide (10.0 g) prepared according to WO 00/20395, was dissolved in a 10% aqueous sodium carbonate solution (30 ml) and then at the temperature of 20° C. the solution was acidified for 60 seconds with a 5% aqueous sulfuric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (8.1 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- The amorphous torasemide modification (10.0 g) prepared according to HR patent application P20000162A, was dissolved in a 10% aqueous potassium carbonate solution (30 ml) and then at the temperature of 20° C. the solution was acidified for 90 seconds with a 10% aqueous tartaric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (8.0 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- The novel polymorph V of torasemide (10.0 g) according to Example 3 of the present invention was dissolved in a 5% aqueous lithium hydroxide solution (30 ml) and then at the temperature of 20° C. the solution was acidified for 120 seconds with a 5% aqueous phosphoric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (7.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- A mixture (1.0 g) of crystalline modifications I and II of torasemide prepared according to Acta Cryst. B34 (1978) 1304-1310, was dissolved in a 10% aqueous sodium carbonate solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 5% aqueous p-toluenesulfonic acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- A mixture (1.0 g) of crystalline modifications I and III of torasemide prepared according to Acta Cryst. B34 (1978) 1304-1310 and WO 00/20395, was dissolved in a 5% aqueous sodium hydroxide solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 5% aqueous nitric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- A mixture (1.0 g) of crystalline modifications II and III of torasemide prepared according to Acta Cryst. B34 (1978) 1304-1310 and WO 00/20395, was dissolved in a 5% aqueous potassium hydroxide solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 10% aqueous propionic acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- A mixture (1.0 g) of crystalline modifications I, II and III of torasemide prepared according to Acta Cryst. B34 (1978) 1304-1310 and WO 00/20395, was dissolved in a 5% aqueous lithium hydroxide solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 10% aqueous oxalic acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- A mixture (1.0 g) of a crystalline modification I of torasemide and an amorphous torasemide modification prepared according to Acta Cryst. B34 (1978) 1304-1310 and HR patent application P20000162A, was dissolved in a 10% aqueous sodium carbonate solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 5% aqueous methanesulfonic acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- A mixture (1.0 g) of a crystalline modification I of torasemide and of the novel polymorph V of torasemide prepared according to Acta Cryst. B34 (1978) 1304-1310 and according to Example 1 of the present invention, was dissolved in a 10% aqueous potassium carbonate solution (3 ml) and then at the temperature of 20° C. the solution was acidified for 15 seconds with a 5% aqueous hydrochloric acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (0.9 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- A mixture (10.0 g) of crystalline modifications I, II and III of torasemide, of an amorphous torasemide modification and of the novel polymorph V of torasemide prepared according to Acta Cryst. B34 (1978) 1304-13 10, WO 00/20395, HR patent application P20000162A and Example 1 of the present invention, was dissolved in a 5% aqueous sodium hydroxide solution (30 ml) and then at the temperature of 20° C. the solution was acidified for 60 seconds with a 10% aqueous acetic acid solution. The crystals were sucked off, washed with demineralized water and acetone and dried in a vacuum dryer for 3 hours at 50° C. A chemically pure novel polymorph V of torasemide (8.0 g), m.p. 153-155° C. was obtained.
- The IR spectrum of the sample thus obtained corresponded to the IR spectrum of the novel polymorph V of torasemide obtained according to Example 1.
- The novel polymorph V of torasemide obtained according to Example 1 of the present invention was subjected to testing the release of the active substance in water at the temperature of 37° C. (USP 24) and the results are given in Table 1.
TABLE 1 Release of the novel polymorph V of torasemide in water (USP 24) (37° C., 50 rpm, 1000 ml) Time Released torasemide (min) (%) 0 0 15 11.3 30 20.5 45 26.0 60 30.0 90 36.0 120 40.7
Claims (17)
1-8. (canceled)
9. A process for the preparation of the crystalline modifications I, II and III torasemide or of an amorphous torasemide modification which comprises using as a raw material a polymorph V of torasemide characterized by the following data:
DSC: exothermic maximum at about 157.59° C. (onset at about 150.74° C.) with the heating rate of 10° C./min;
X-ray powder pattern (2Θ) : 5.610; 6.130; 7.480; 7.970; 9.310; 9.615; 10.835; 11.020; 12.340; 13.075; 13.460; 13.920; 14.200; 15.090; 16.080; 16.710; 17.445; 17.720; 18.460; 18.850; 19.825; 20.340; 20.990; 21.980; 22.075; 22.630; 22.935; 23.410; 23.845; 24.880; 25.560; 26.035; 27.285; 27.540; 28.170; 28.645; 29.350; 29.975; 30.575; 31.265; 32.300; 34.050; 35.650; 36.375; 37.100 and 38.145;
IR-characteristic absorption bands at 2671 to 3327 and at 1468 to 1705cm−1.
10. A process for the preparation of pharmaceutically acceptable salts of torasemide which comprises using a polymorph V of torasemide characterized by the following data:
DSC: exothermic maximum at about 157.59° C. (onset at about 150.74° C.) with the heating rate of 10° C./min;
X-ray powder pattern (2Θ): 5.610; 6.130; 7.480; 7.970; 9.310; 9.615; 10.835; 11.020; 12.340; 13.075; 13.460; 13.920; 14.200; 15.090; 16.080; 16.710; 17.445; 17.720; 18.460; 18.850; 19.825; 20.340; 20.990; 21.980; 22.075; 22.630; 22.935; 23.410; 23.845; 24.880; 25.560; 26.035; 27.285; 27.540; 28.170; 28.645; 29.350; 29.975; 30.575; 31.265; 32.300; 34.050; 35.650; 36.375; 37.100 and 38.145;
IR-characteristic absorption bands at 2671 to 3327 and at 1468 to 1705 cm−1.
11. (canceled)
12. Pharmaceutical form, characterized in that as an active ingredient it contains an effective amount of a polymorph V of torasemide characterized by the following data:
DSC: exothermic maximum at about 157.59° C. (onset at about 150.74° C.) with the heating rate of 10° C./min;
X-ray powder pattern (2Θ): 5.610; 6.130; 7.480; 7.970; 9.310; 9.615; 10.835; 11.020; 12.340; 13.075; 13.460; 13.920; 14.200; 15.090; 16.080; 16.710; 17.445; 17.720; 18.460; 18.850; 19.825; 20.340; 20.990; 21.980; 22.075; 22.630; 22.935; 23.410; 23.845; 24.880; 25.560; 26.035; 27.285; 27.540; 28.170; 28.645; 29.350; 29.975; 30.575; 31.265; 32.300; 34.050; 35.650; 36.375; 37.100 and 38.145;
IR-characteristic absorption bands at 2671 to 3327 and at 1468 to 1705 cm−1, without or in combination with one or more pharmaceutically acceptable additives.
13. Pharmaceutical form according to claim 12 , characterized in that it is a tablet, a capsule or an injection.
14. A method of treatment selected from the group consisting of treating a patient in need of a diuretic; a patient suffering from
heart or heart tissue damages caused by metabolic or ionic abnormalities associated with ischemia; and
patient suffering from a treating a cenaitium selected from the group consisting of thrombosis, angina pectoris, asthma, hypertension, nephroedema, pulmonary edema, primary and secondary aldosteronism, Bartter's syndrome, tumors, glaucoma, decreasing of intraocular pressure, acute or chronic bronchitis, cerebral edema caused by trauma, ischemia, concussion of the brain, metastases or epileptic attacks, and nasal infections caused by allergens;
by administering to said patient an effecture amount of a polymorph V of torasemide characterized by the following data:
DSC: exothermic maximum at about 157.59° C. (onset at about 150.74° C.) with the heating rate of 10° C./min;
X-ray powder pattern (2Θ) : 5.610; 6.130; 7.480; 7.970; 9.310; 9.615; 10.835; 11.020; 12.340; 13.075; 13.460; 13.920; 14.200; 15.090; 16.080; 16.710; 17.445; 17.720; 18.460; 18.850; 19.825; 20.340; 20.990; 21.980; 22.075; 22.630; 22.935; 23.410; 23.845; 24.880; 25.560; 26.035; 27.285; 27.540; 28.170; 28.645; 29.350; 29.975; 30.575; 31.265; 32.300; 34.050; 35.650; 36.375; 37.100, and 38.145;
IR-characteristic absorption bands at 2671 to 3327 and at 1468 to 1705 cm−1.
15. Pharmaceutical form according to claim 12 wherein said pharmaceutically acceptable additives are selected from the group consisting of sugar, starch, starch derivatives, cellulose, cellulose derivatives, mould release agents, antiadhesive agents and agents for regulating flowability.
16. Pharmaceutical form according to claim 12 wherein said polymorph V of torasemide is chemically pure.
17. Pharmaceutical form according to claim 12 wherein said polymorph V of torasemide contains no water.
18. Pharmaceutical form according to claim 12 wherein said polymorph V of torasemide contains no solvent.
19. Pharmaceutical form according to claim 15 wherein said polymorph V of torasemide is chemically pure.
20. Pharmaceutical form according to claim 15 wherein said polymorph V of torasemide contains no water.
21 Pharmaceutical form according to claim 15 wherein said polymorph V of torasemide contains no solvent.
22. The method according to claim 14 wherein said polymorph V of torasemide contains no water.
23. The method according to claim 14 wherein said polymorph V of torasemide contains no solvent.
24. The method according to claim 14 polymorph V of torasemide is chemically pure.
Priority Applications (1)
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US11/763,156 US20070238759A1 (en) | 2000-05-19 | 2007-06-14 | Novel Polymorph V of Torasemide |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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HR20000328A HRP20000328A2 (en) | 2000-05-19 | 2000-05-19 | Novel polymorph v of torasemide |
HRP20000328A | 2000-05-19 | ||
PCT/HR2000/000033 WO2001087841A1 (en) | 2000-05-19 | 2000-09-25 | Novel polymorph v of torasemide |
US27688103A | 2003-06-11 | 2003-06-11 | |
US11/763,156 US20070238759A1 (en) | 2000-05-19 | 2007-06-14 | Novel Polymorph V of Torasemide |
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PCT/HR2000/000033 Division WO2001087841A1 (en) | 2000-05-19 | 2000-09-25 | Novel polymorph v of torasemide |
US27688103A Division | 2000-05-19 | 2003-06-11 |
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US10/276,881 Expired - Fee Related US7241782B1 (en) | 2000-05-19 | 2000-09-25 | Polymorph V of torasemide |
US11/763,156 Abandoned US20070238759A1 (en) | 2000-05-19 | 2007-06-14 | Novel Polymorph V of Torasemide |
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EP (1) | EP1283828B1 (en) |
JP (1) | JP2003533512A (en) |
KR (1) | KR20030016267A (en) |
CN (1) | CN1520403A (en) |
AP (1) | AP2002002679A0 (en) |
AR (1) | AR028840A1 (en) |
AT (1) | ATE342890T1 (en) |
AU (1) | AU2000274381A1 (en) |
BG (1) | BG107407A (en) |
BR (1) | BR0015877A (en) |
CA (1) | CA2409699A1 (en) |
CZ (1) | CZ20024104A3 (en) |
DE (1) | DE60031450T2 (en) |
DZ (1) | DZ3356A1 (en) |
EA (1) | EA005003B1 (en) |
EE (1) | EE200200637A (en) |
GE (1) | GEP20043321B (en) |
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MA (1) | MA25748A1 (en) |
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NO (1) | NO20025509D0 (en) |
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PL (1) | PL358257A1 (en) |
SK (1) | SK17712002A3 (en) |
TR (1) | TR200202544T2 (en) |
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Cited By (1)
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US20050158949A1 (en) * | 2003-09-04 | 2005-07-21 | Manning Homer M. | Semiconductor devices |
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AU781461C (en) * | 1999-08-11 | 2006-02-23 | Teva Pharmaceutical Industries Ltd. | Torsemide polymorphs |
IN192178B (en) | 2001-08-03 | 2004-03-06 | Ranbaxy Lab | |
CN1824647B (en) * | 2005-02-22 | 2011-04-20 | 田边三菱制药株式会社 | Crystal of (+-)2-(dimethylamino)-1-{[o-(m-methoxyphenethyl)phenoxy]methyl}ethyl hydrogen succinate hydrochloride |
CN100421662C (en) * | 2005-11-08 | 2008-10-01 | 周卓和 | Disperese torasemide tablet and its prepn and application |
CN104370805B (en) * | 2013-08-13 | 2016-09-07 | 天津汉瑞药业有限公司 | Torasemide compound |
CN105949115A (en) * | 2016-05-26 | 2016-09-21 | 南京正科医药股份有限公司 | Novel crystal form torasemide |
CN115417810B (en) * | 2022-09-22 | 2023-10-10 | 南京正科医药股份有限公司 | Refining method of torsemide crystal form I |
CN117486789A (en) * | 2023-12-29 | 2024-02-02 | 江西中医药大学 | Torase Mi Gongjing salt and preparation method and application thereof |
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2000
- 2000-05-19 HR HR20000328A patent/HRP20000328A2/en not_active Application Discontinuation
- 2000-06-26 AR ARP000103199A patent/AR028840A1/en unknown
- 2000-09-25 DZ DZ003356A patent/DZ3356A1/en active
- 2000-09-25 US US10/276,881 patent/US7241782B1/en not_active Expired - Fee Related
- 2000-09-25 WO PCT/HR2000/000033 patent/WO2001087841A1/en active IP Right Grant
- 2000-09-25 YU YU84202A patent/YU84202A/en unknown
- 2000-09-25 SK SK1771-2002A patent/SK17712002A3/en unknown
- 2000-09-25 EA EA200201236A patent/EA005003B1/en not_active IP Right Cessation
- 2000-09-25 CN CNA008196567A patent/CN1520403A/en active Pending
- 2000-09-25 KR KR1020027015607A patent/KR20030016267A/en not_active Application Discontinuation
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- 2000-09-25 NZ NZ522544A patent/NZ522544A/en unknown
- 2000-09-25 EE EEP200200637A patent/EE200200637A/en unknown
- 2000-09-25 PL PL00358257A patent/PL358257A1/en not_active Application Discontinuation
- 2000-09-25 BR BR0015877-1A patent/BR0015877A/en not_active IP Right Cessation
- 2000-09-25 GE GE4998A patent/GEP20043321B/en unknown
- 2000-09-25 AT AT00962739T patent/ATE342890T1/en not_active IP Right Cessation
- 2000-09-25 EP EP00962739A patent/EP1283828B1/en not_active Expired - Lifetime
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