DE69011198T2 - Verfahren zur Differenzierung von Leukozyten mit Hilfe eines Durchflusszellmessgerätes. - Google Patents

Verfahren zur Differenzierung von Leukozyten mit Hilfe eines Durchflusszellmessgerätes.

Info

Publication number
DE69011198T2
DE69011198T2 DE69011198T DE69011198T DE69011198T2 DE 69011198 T2 DE69011198 T2 DE 69011198T2 DE 69011198 T DE69011198 T DE 69011198T DE 69011198 T DE69011198 T DE 69011198T DE 69011198 T2 DE69011198 T2 DE 69011198T2
Authority
DE
Germany
Prior art keywords
leukocytes
differentiation
help
procedure
measuring device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69011198T
Other languages
English (en)
Other versions
DE69011198D1 (de
Inventor
Paul N Marshall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69011198D1 publication Critical patent/DE69011198D1/de
Application granted granted Critical
Publication of DE69011198T2 publication Critical patent/DE69011198T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666Particle count or volume standard or control [e.g., platelet count standards, etc.]
DE69011198T 1989-05-15 1990-05-15 Verfahren zur Differenzierung von Leukozyten mit Hilfe eines Durchflusszellmessgerätes. Expired - Fee Related DE69011198T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35210689A 1989-05-15 1989-05-15

Publications (2)

Publication Number Publication Date
DE69011198D1 DE69011198D1 (de) 1994-09-08
DE69011198T2 true DE69011198T2 (de) 1995-01-19

Family

ID=23383823

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69011198T Expired - Fee Related DE69011198T2 (de) 1989-05-15 1990-05-15 Verfahren zur Differenzierung von Leukozyten mit Hilfe eines Durchflusszellmessgerätes.

Country Status (8)

Country Link
US (1) US5510267A (de)
EP (1) EP0398652B1 (de)
JP (1) JPH0726956B2 (de)
AT (1) ATE109568T1 (de)
AU (1) AU636607B2 (de)
CA (1) CA2016699C (de)
DE (1) DE69011198T2 (de)
ES (1) ES2060949T3 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0626067A4 (de) * 1992-02-07 1997-06-25 Abbott Lab Verfahren zur genauen zählung und empfindlichen qualifizierung heterogener zellpopulationen unter zytolytischen behandlungsbedingungen.
US6509192B1 (en) * 1992-02-24 2003-01-21 Coulter International Corp. Quality control method
EP0582736A1 (de) * 1992-08-11 1994-02-16 Abbott Laboratories Hüllflüssigkeitszusammensetzung für Durchflusszytometrie zur Eliminierung von Erythrocyten und Konservierung von nukleierten Zellen
DE69327775T2 (de) * 1992-11-19 2000-06-21 Sysmex Corp Verfahren zur Vorbehandlung für Blutanalyse
US6812032B1 (en) * 1993-01-21 2004-11-02 Cdc Technologies, Inc. Apparatus and method for making a plurality of reagent mixtures and analyzing particle distributions of the reagent mixtures
JP3355038B2 (ja) * 1994-08-03 2002-12-09 シスメックス株式会社 白血球分類方法
FR2733835B1 (fr) * 1995-05-03 1997-07-18 Hycel Groupe Lisabio Procede et dispositif de detection du point de lyse de globules rouges
US5639630A (en) * 1995-05-16 1997-06-17 Bayer Corporation Method and reagent composition for performing leukocyte differential counts on fresh and aged whole blood samples, based on intrinsic peroxidase activity of leukocytes
WO1997022870A1 (en) * 1995-12-18 1997-06-26 Center For Laboratory Technology, Inc. Multi-parameter hematology apparatus and method
US5817518A (en) * 1995-12-18 1998-10-06 Coulter International Corp. Reagent and method for differential determination of leukocytes in blood
US5817519A (en) * 1995-12-28 1998-10-06 Bayer Corporation Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples
US6025201A (en) * 1995-12-28 2000-02-15 Bayer Corporation Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples
US5917584A (en) * 1997-11-21 1999-06-29 Coulter International Corp. Method for differentiation of nucleated red blood cells
US5874310A (en) * 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of nucleated red blood cells
US6304328B1 (en) * 1998-08-14 2001-10-16 Research Foundation Of State University Of New York, The Office Of Technology Licensing, Suny Non-contact temperature and concentration measurement on liquid surfaces
US6067157A (en) * 1998-10-09 2000-05-23 University Of Washington Dual large angle light scattering detection
US6423505B1 (en) * 1998-12-03 2002-07-23 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
US6200766B1 (en) 1998-12-03 2001-03-13 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells
US6210969B1 (en) * 1999-04-28 2001-04-03 Coulter International Corp. Composition and method for differentiation of basophil and eosinophil subpopulations of leukocytes in blood
US6214625B1 (en) * 1999-04-28 2001-04-10 Coulter International Corp. Composition and method for differentiation of basophils and eosinophils in blood
US6232125B1 (en) 1999-08-09 2001-05-15 Coulter International Corp. Method and apparatus for differentiating and enumerating leukocytes
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US20060263888A1 (en) * 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US8071051B2 (en) 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US8329118B2 (en) 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US6784981B1 (en) 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
US7420659B1 (en) * 2000-06-02 2008-09-02 Honeywell Interantional Inc. Flow control system of a cartridge
US7471394B2 (en) * 2000-08-02 2008-12-30 Honeywell International Inc. Optical detection system with polarizing beamsplitter
US7242474B2 (en) * 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US7277166B2 (en) * 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US7061595B2 (en) * 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
JP4097597B2 (ja) 2001-06-01 2008-06-11 富士通株式会社 光磁気記録媒体装置
US6869798B2 (en) * 2003-04-17 2005-03-22 Clinical Diagnostics Solutions, Inc. Lytic reagent composition for leukocyte differential analysis
US8323564B2 (en) * 2004-05-14 2012-12-04 Honeywell International Inc. Portable sample analyzer system
US8828320B2 (en) * 2004-05-14 2014-09-09 Honeywell International Inc. Portable sample analyzer cartridge
US7630075B2 (en) * 2004-09-27 2009-12-08 Honeywell International Inc. Circular polarization illumination based analyzer system
US20060179731A1 (en) * 2004-11-02 2006-08-17 Purvis Harrison G Temporary railing for a building including access opening and associated methods
FR2883972B1 (fr) * 2005-03-31 2007-11-16 C2 Diagnostics Sa Procede pour l'analyse d'un echantillon de sang et appareil et reactif pour sa mise en oeuvre
JP4965561B2 (ja) 2005-04-29 2012-07-04 ハネウェル・インターナショナル・インコーポレーテッド サイトメータ細胞計数及びサイズ測定システム
US8273294B2 (en) * 2005-07-01 2012-09-25 Honeywell International Inc. Molded cartridge with 3-D hydrodynamic focusing
WO2007005973A2 (en) * 2005-07-01 2007-01-11 Honeywell International, Inc. A microfluidic card for rbc analysis
WO2007005974A2 (en) * 2005-07-01 2007-01-11 Honeywell International, Inc. A flow metered analyzer
US7843563B2 (en) * 2005-08-16 2010-11-30 Honeywell International Inc. Light scattering and imaging optical system
US7806604B2 (en) * 2005-10-20 2010-10-05 Honeywell International Inc. Face detection and tracking in a wide field of view
EP1963866B1 (de) * 2005-12-22 2018-05-16 Honeywell International Inc. Hematologischer analysator mit entfernbarer kartusche
WO2007076549A2 (en) * 2005-12-29 2007-07-05 Honeywell International Inc. Assay implementation in a microfluidic format
US7674622B2 (en) * 2006-12-22 2010-03-09 Abbott Laboratories, Inc. Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer
US7449337B2 (en) * 2007-01-24 2008-11-11 Idexx Laboratories, Inc. Lytic reagent and method for leukocytes differential in whole blood
US7816135B2 (en) 2007-07-05 2010-10-19 Becton, Dickinson And Company Method of analyzing lymphocytes
CN101349644B (zh) * 2007-07-20 2012-06-27 深圳迈瑞生物医疗电子股份有限公司 一种白细胞分类试剂和其使用方法
US8102161B2 (en) * 2007-09-25 2012-01-24 Tdk Corporation Stable output in a switching power supply by smoothing the output of the secondary coil
JP2009083382A (ja) * 2007-10-01 2009-04-23 Brother Ind Ltd 画像形成装置および画像処理プログラム
CN101470108B (zh) 2007-12-24 2013-11-27 深圳迈瑞生物医疗电子股份有限公司 一种对白细胞进行分类的试剂和方法
CN101475754A (zh) * 2008-01-04 2009-07-08 深圳迈瑞生物医疗电子股份有限公司 不对称菁类荧光染料,组合物及在生物样品染色中的用途
EP2247746A4 (de) * 2008-01-31 2012-08-01 Amyris Inc Verfahren zur überwachung von stoffwechselwegen
JP2009236798A (ja) * 2008-03-28 2009-10-15 Sysmex Corp 好塩基球の分類計数方法
CN104965068B (zh) 2008-05-09 2017-12-08 希森美康株式会社 血液分析装置,血液分析方法及溶血剂
CN101602762B (zh) * 2008-06-10 2013-10-16 深圳迈瑞生物医疗电子股份有限公司 不对称菁类化合物、其制备方法及应用
US20100034704A1 (en) * 2008-08-06 2010-02-11 Honeywell International Inc. Microfluidic cartridge channel with reduced bubble formation
US8037354B2 (en) 2008-09-18 2011-10-11 Honeywell International Inc. Apparatus and method for operating a computing platform without a battery pack
CN101726579B (zh) * 2008-10-17 2014-06-18 深圳迈瑞生物医疗电子股份有限公司 血液检测试剂和方法
CN101750274B (zh) * 2008-12-17 2014-06-25 深圳迈瑞生物医疗电子股份有限公司 白细胞分类计数试剂、试剂盒以及白细胞分类计数的方法
CN101988082B (zh) * 2009-07-31 2015-04-08 深圳迈瑞生物医疗电子股份有限公司 白细胞分类计数试剂、试剂盒及其制备方法和白细胞分类计数的方法
JP4907705B2 (ja) * 2009-09-29 2012-04-04 シスメックス株式会社 尿中赤血球分析用試薬
US9091677B2 (en) 2010-08-09 2015-07-28 Beckman Coulter, Inc. Isotonic buffered composition and method that enables counting of cells
US8741235B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Two step sample loading of a fluid analysis cartridge
US8663583B2 (en) 2011-12-27 2014-03-04 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741233B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741234B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
JP6692743B2 (ja) * 2013-03-12 2020-05-13 アボット・ラボラトリーズAbbott Laboratories 白血球を分析するための試薬、システム、及び方法
WO2015073952A1 (en) * 2013-11-15 2015-05-21 University Of Maryland Integrated and standalone label and reagent-free microfluidic devices and microsystems for differential white blood cell counts
JP6976167B2 (ja) 2014-06-13 2021-12-08 キュー−リネア エービー 微生物の検出及び特徴付け方法
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
NO340218B1 (en) 2015-07-10 2017-03-20 Marine Harvest Norway As Device and method for removing parasites on fish
WO2017078672A1 (en) 2015-11-02 2017-05-11 Chiranjit Deka Light scatter based apparatus and methods for hematology analysis using only three detectors
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
EP3634528B1 (de) 2017-06-07 2023-06-07 Shifamed Holdings, LLC Intravaskuläre fluidbewegungsvorrichtungen, systeme und verwendungsverfahren
CN111556763B (zh) 2017-11-13 2023-09-01 施菲姆德控股有限责任公司 血管内流体运动装置、系统
JP7410034B2 (ja) 2018-02-01 2024-01-09 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに使用および製造の方法
US10914913B2 (en) 2018-03-30 2021-02-09 Idexx Laboratories, Inc. Flow cytometer, laser optics assembly thereof, and methods of assembling the same
WO2021016372A1 (en) 2019-07-22 2021-01-28 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
EP4034192A4 (de) 2019-09-25 2023-11-29 Shifamed Holdings, LLC Intravaskuläre blutpumpensysteme und verfahren zur verwendung und steuerung davon
AU2021293085A1 (en) 2020-06-17 2023-02-16 Idexx Laboratories Inc. Flow cytometer and laser optics assembly thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3874852A (en) * 1974-07-05 1975-04-01 Coulter Diagnostics Inc Reagent and method for determining leukocytes and hemoglobin in the blood
US3962125A (en) * 1975-01-13 1976-06-08 Coulter Diagnostics, Inc. Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type
US4185964A (en) * 1977-02-08 1980-01-29 Central Laboratories of Associated Maryland Pathologists, Ltd. Lysing reagent
US4099917A (en) * 1977-07-21 1978-07-11 Technicon Instruments Corporation Process for preparing a cell suspension from blood for discrimination of white blood cells and platelets from other blood particles
US4577964A (en) * 1978-09-06 1986-03-25 Ortho Diagnostics, Inc. Apparatus and method for detecting platelets in whole blood
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4286963A (en) * 1979-11-23 1981-09-01 Coulter Electronics, Inc. Differential lymphoid-myeloid determination of leukocytes in whole blood
US4465774A (en) * 1981-07-16 1984-08-14 Sherwood Medical Company Standard or control material for glysocylated or total hemoglobin determination
US4506018A (en) * 1982-12-30 1985-03-19 Becton, Dickinson And Company Blood diluent
US4485175A (en) * 1983-01-03 1984-11-27 Coulter Electronics, Inc. Method for three-volume differential determination of lymphocyte, monocyte and granulocyte populations of leukocytes
US4743678A (en) * 1983-04-27 1988-05-10 President And Fellows Of Harvard College Method and products for detection of human T cell leukemia virus
US4637986A (en) * 1983-08-22 1987-01-20 Ortho Diagnostic Systems, Inc. Flow cytometry lysing reagent with leukoprotective agent for producing a 3-part WBC count
JPS6073356A (ja) * 1983-09-29 1985-04-25 Toa Medical Electronics Co Ltd 血液分析用試薬
US4902613A (en) * 1984-05-14 1990-02-20 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
US4654312A (en) * 1984-05-14 1987-03-31 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
US4751179A (en) * 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4745071A (en) * 1985-09-05 1988-05-17 Sequoia-Turner Corporation Method for the volumetric differentiation of blood cells types
NL8601000A (nl) * 1986-04-21 1987-11-16 Jan Greve T H Twente Afdeling Het gebruik van gepolariseerd licht in stromingscytometrie.
JPH0635972B2 (ja) * 1986-11-27 1994-05-11 東亜医用電子株式会社 フロ−サイトメトリ−による白血球の分類方法
US5039613A (en) * 1986-11-27 1991-08-13 Toa Medical Electronics Co., Ltd. Reagents used in a method of classifying leukocytes by flow cytometry
JPH0782010B2 (ja) * 1987-10-16 1995-09-06 東亜医用電子株式会社 粒子分析装置用シース液

Also Published As

Publication number Publication date
EP0398652A1 (de) 1990-11-22
JPH0726956B2 (ja) 1995-03-29
DE69011198D1 (de) 1994-09-08
AU636607B2 (en) 1993-05-06
JPH034171A (ja) 1991-01-10
CA2016699C (en) 2003-11-18
AU5503790A (en) 1990-11-15
CA2016699A1 (en) 1990-11-15
US5510267A (en) 1996-04-23
ATE109568T1 (de) 1994-08-15
EP0398652B1 (de) 1994-08-03
ES2060949T3 (es) 1994-12-01

Similar Documents

Publication Publication Date Title
DE69011198D1 (de) Verfahren zur Differenzierung von Leukozyten mit Hilfe eines Durchflusszellmessgerätes.
DE69033796D1 (de) Verfahren und gerät zum nachweis und zur quantifizierung von glukose in körperflüssigkeiten
FI891078A (fi) Peptider och antikroppar, som inhiberar plateletadhesion.
ATE98773T1 (de) Verfahren zur optischen analyse.
IT1270130B (it) Strumento diagnostico automatizzato in particolare per l'analisi di campioni in pacchi di prova per un analita
DE69132513T2 (de) Vorrichtung und verfahren zur festphase-präzipitationsbestimmung von hdl-cholesterin
NO964982D0 (no) Detektering av reticulocytter
ES2147555T3 (es) Ensayo de proteinas de la matriz nuclear en fluidos.
ATE225841T1 (de) In der hämatologischen analyse von vollblutproben verwendetes universales reagenzspülmittel
DE3668243D1 (de) Verfahren und vorrichtung zum durchfuehren von klinischen analysen mittels trockenreagenzien.
KR960007789A (ko) 단백질 c/단백질 s시스템의 장해를 검출하기 위한 방법
HUT61491A (en) Process and reagent for diagnosing prothrombic state
ES2161228T3 (es) Procedimiento para controlar la contaminacion virica en muestras de sangre.
DK0724619T3 (da) Rengøringsopløsning for automatiske analyseapparater
CA2242693A1 (en) Additive formulation and method of use thereof
DE59108478D1 (de) Funktioneller Test zur Bestimmung der Protein S-Aktivität
ATE203824T1 (de) Vorrichtung und verfahren zur optischen, hämostatischen blutanalyse
EP0866654A4 (de) Methode für die behandlung einer hepatitisvirusinfektion
ATE313800T1 (de) Verfahren zur analyse der funktionellen aktivierung von leukocyten, plättchen und anderen zellen
Chen Review on Complexation
DE69128193T2 (de) Verfahren zur bestimmung von gesamtem kalzium unter verwendung eines verdünnungsmittels
Money et al. Exhaled breath analysis: A suitable technique for assessing occupational exposures to organic vapours?.
IT218277Z2 (it) Provetta o cuvetta ad uso apparecchio per l'analisi chimica, biomedica e per la sedimentazione.
RU94022739A (ru) Метод оценки содержания лейкоцитов в крови

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee