CN106572914A - Compositions, devices, kits and methods for attaching stent-containing medical devices to tissue - Google Patents
Compositions, devices, kits and methods for attaching stent-containing medical devices to tissue Download PDFInfo
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- CN106572914A CN106572914A CN201580035084.5A CN201580035084A CN106572914A CN 106572914 A CN106572914 A CN 106572914A CN 201580035084 A CN201580035084 A CN 201580035084A CN 106572914 A CN106572914 A CN 106572914A
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- medical treatment
- treatment device
- jointing material
- jointing
- carriage assembly
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/94—Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present disclosure is directed to methods, compositions, devices and kits which pertain to the attachment of stent-containing medical devices to tissue.
Description
Cross-Reference to Related Applications
This application claims the rights and interests of the provisional application of the Serial No. 62/018,262 proposed on June 27th, 2014, its
Full content is incorporated herein by.
Technical field
The present invention relates to for compositionss, device, external member and program by tissue is attached to containing standoff medical treatment device.
Background technology
For example, support is for treating narrow or weak tube chamber (for example, tremulous pulse, vein, bile duct, esophagus, intestinal, lung etc.) to support
Disappear the little netted pipe shunk due to the tube chamber that various diseases and situation cause.Support can be by metal, polymer or other are suitable
Material is made.Support can be Biostatic or biological absorbable, medicament elution or non-drug eluting.Support is most normal
The purposes seen is used in coronary artery.The support of other common types in addition to coronary stent includes peripheral blood vessel
Support, ureter bracket (for example, to guarantee ureteral smoothness), biliary tract rack are (for example, in treat bile duct or ductus pancreaticus
Obstruction), Esophageal Stent (for example, to treat the blocking of esophaguses), intestinal stent (for example, to treat the blocking of small intestinal or colon) and
Airway stent (for example, to treat trachea or bronchial blocking) etc..
In some cases, support is capped.If the covering of coating lid support has hole, it is typically used for
In vascular system, then which is commonly known as stent graft.Stent graft is used for into what is treated abdominal aortic aneurysm and weaken
Peripheral arterial.In other purposes, other capped supports can be used to the pernicious or benign stricture for treating esophaguses and each
Plant the leakage and/or perforation in body cavity.In some cases, capped support is interim placement and is removable.
No matter support be cover, part covers or non-covered, in the placement of support, fixation is extremely important
, if this is because implant occurs migration, treatment may be damaged and further complication may occur.
Used as a specific example, placing capped self expandable metal or polymer support has become unresectable
The first choice for appeasing Sex therapy of the esophageal carcinoma.These supports are let out for benign (digestibility, postoperative, corrosivity) narrow, esophaguses
It is also highly effective for leakage, perforation and the process of fistula.In most of the cases, it is possible to achieve the quick of dysphagia is delayed
Solution and enough nutrient orals are taken in.If support is migrated to, in such as causing the stomach or small intestinal of obstruction, patient then may be used from esophaguses
Serious pain and heating can be subjected to, be which results in for removing the additional surgical of support.This be apply equally as well to other GI and
Airway stent.
As another instantiation, abdominal aortic aneurysm (AAA) stent graft is usually used to solve aneurysm, which is special
It is weak arterial wall to levy.As time goes on, blood pressure and other factors the weakness zone may be made raised as sacculus and
Which can finally expand and rupture.AAA stent grafts are designed to the tremulous pulse above and below aneurysm closely
It is sealed.Graft is more higher than the tremulous pulse for weakening and which allows blood by without occurring to push in projection.If
Stent graft will occur migration, and the sealing above aneurysm may then be damaged.This may cause blood to flow into aneurysmal sack
Make its growth and rupture may occur.May need to intervene again.
The content of the invention
According to certain aspects of the invention, there is provided containing standoff device, which includes associated jointing material, wherein
It is configured to while contacting with tube chamber containing standoff device containing standoff device, bonds when energy source is exposed to
To tube chamber.
In certain aspects, it is it is a feature of the present invention that medical treatment device, which includes (a) carriage assembly, (b) optional to cover
Material, and (c) and carriage assembly, optional covering material or jointing material that both is associated;Its medical device quilt
It is configured to be implanted in patient's body and neighbouring patient is bonded to when jointing material is exposed to the energy for coming from energy source
Tissue.
In some embodiments that can be used in combination with any of above aspect, jointing material includes tissue solders material, glues
Condensation material includes tissue solders and photosensitizing dye, or jointing material includes tissue solders and energy absorber.
In some embodiments that can be used in combination with any of above aspect and embodiment, jointing material includes poly- selected from shell
Sugar, albumin, collagen protein, elastin, Fibrinogen, nano peptide, aforesaid derivant and aforesaid two or more
The tissue solders of combination.
In some embodiments that can be used in combination with any of above aspect and embodiment, jointing material includes tissue solders
And photosensitizing dye, photosensitizing dye is selected from rose-bengal dyestuff, methylene blue dye, fluorescein(e) dye, indocyanine green, alkaline product
Red, phenol, xanthane dyestuff, riboflavin dyestuff, photopigment dyestuff, flavin, photoflavin dyestuff, reactive black 5 dye and aforementioned two
Plant the combination of the above.
In some embodiments that can be used in combination with any of above aspect and embodiment, jointing material includes tissue solders
And energy absorber, energy absorber is selected from chromophore, SPIO nano particle (SPIONs), gold nanorods, gold
Nanoshell, gold nanometer cage and aforementioned two or more combination.
In some embodiments that can be used in combination with any of above aspect and embodiment, jointing material includes tissue solders
And synthetic polymer, synthetic polymer selected from polylactic acid, polyglycolic acid, poly- (lactic-co-glycolic acid), polydioxanone, gather oneself
Lactone and aforementioned two or more combination.
In the further aspect that can be used in combination with any of above aspect and embodiment, jointing material (a) by
The coating of the jointing material on carriage assembly, optional covering material or at least a portion of both, (b) by bonding
Material is integrated in carriage assembly, optional covering material or at least a portion of both, or (c) is by aforesaid combination
It is associated with medical treatment device.
In the further aspect that can be used in combination with any of above aspect and embodiment, jointing material and medical treatment device
End, rather than be associated with the center of medical treatment device, or a series of band as the length along medical treatment device or island come
Jointing material is provided.
In the further aspect that can be used in combination with any of above aspect and embodiment, medical treatment device includes optionally
Covering material.Covering material can be with, for example, covers whole carriage assembly or only covers a part for carriage assembly.For example, at certain
In a little embodiments, only the end of carriage assembly can be covered by covering material, or covering material can be provided with multiple openings, the plurality of
The region that opening is not covered by covering material there is provided carriage assembly.In certain embodiments, covering material only covers support group
A part for part, and jointing material carriage assembly not by covering material cover region in be associated with carriage assembly.
In the further aspect that can be used in combination with any of above aspect and embodiment, medical treatment device includes optionally
Covering material, and covering material for the energy for coming from energy source be enough to it is transparent, with can be using the position relative to covering material
The jointing material outside tube chamber is located at relative to covering material in the activation of intraluminal energy source.
Method of the other aspects of the present invention there is provided tube chamber will be attached to containing standoff medical treatment device, wherein will come from
The energy of energy source applies to the jointing material being associated with containing standoff medical treatment device to activate jointing material and will contain
The device of support is attached to tube chamber.In certain embodiments, in the method using containing standoff medical treatment device, such as any
Those described in above-mentioned aspect and embodiment.
Other aspects of the present invention are characterised by the external member for including any two or more combination in any in following items:
(a) containing standoff medical treatment device, it include carriage assembly, optional covering and with carriage assembly, optional covering or
Both associated optional jointing material, (b) using solid form or the jointing material of fluid form, (c) surgical device,
, with or without associated energy source, the surgical device is configured to receive medical treatment device and be placed on experimenter for which
In vivo, (d) seal wire, which is with or without associated energy source, or (e) separate energy source.In certain embodiments, exist
Using containing standoff medical treatment device in the external member, as in terms of any of above and described in embodiment.
It is an advantage of the present invention to provide compositionss, device, external member and program, thus can be implanted into containing standoff in body cavity
Medical treatment device, and with the activation of jointing material, so as to farthest reduce after the implantation or anti-locking apparatus are endoceliac
Migration.
It is an advantage of the present invention to provide compositionss, device, external member and program, thus can be implanted into containing standoff in body cavity
Medical treatment device, the support for particularly covering, and with the activation of jointing material, device is sealed so as to be relevant to body cavity.
Description of the drawings
Fig. 1 is the schematic diagram of the support containing solder according to one embodiment of the present of invention;
Fig. 2 is the schematic diagram of the support containing solder according to an alternative embodiment of the invention;
Fig. 3 is the schematic diagram of the support containing solder according to an alternative embodiment of the invention;
Fig. 4 is the schematic diagram of the support containing solder according to an alternative embodiment of the invention;
Fig. 5 A are the schematic diagram of the support containing solder according to an alternative embodiment of the invention;
Fig. 5 B are the schematic diagram of the support containing solder according to an alternative embodiment of the invention;
Fig. 6 is the schematic diagram of the support containing solder according to an alternative embodiment of the invention;
Fig. 7 A, 7B and 7C are the schematic diagram of the method for the implantation support according to one embodiment of the present of invention;
Fig. 8 A, 8B and 8C are the schematic diagram of the method for the implantation support according to an alternative embodiment of the invention;
Fig. 9 is the schematic diagram of the method for the implantation support according to an alternative embodiment of the invention;
Figure 10 is the schematic diagram of the energy emitting device according to one embodiment of the present of invention;
Figure 11 is the schematic diagram of the energy emitting device according to an alternative embodiment of the invention;
Figure 12 is the schematic diagram of the energy emitting device according to an alternative embodiment of the invention.
Specific embodiment
The present invention relates to can be used in experimenter, usually vertebrate subject and more typically mammal is tested
It is implanted in the body cavity of person, such as human experimenter, house pet or domestic animal and fixed containing standoff medical treatment device, for example, bare bracket, medicine
The method of support that thing FirebirdTM, part cover and the support that is completely covered etc., compositionss, device and external member.The device can
In various tube chambers, for example, blood vessel (for example, tremulous pulse, vein etc.), gastrointestinal tube chamber (for example, esophaguses, Stomach duodenum,
Small intestinal, large intestine, colon, bile duct etc.), urogenital tube chamber (for example, ureter, urethra, fallopian tube etc.) or air flue chamber is (for example,
Trachea-bronchial epithelial cell etc.) etc. in be implanted into and fixed, such as to prevent in intraluminal migration and/or create and tube chamber
Sealing (for example, in the case of using support is covered).In various embodiments, provide following using containing standoff device
More than one in function:Support the smoothness of body cavity, strengthen body lumen wall, seal body lumen wall and prevent in tissue to body cavity to
Interior growth etc..
According on one side, the present invention relates to contain standoff device, which is configured to be implanted in body cavity, its bag
(a) carriage assembly is included, (b) optional covering material and (c) jointing material.Jointing material and containing standoff device at least one
Part it is associated (for example, with carriage assembly, optional covering or both be associated), so that containing standoff device energy
It is enough that adjacent patient tissue is bonded to when energy is exposed to.For example, jointing material can pass through one in following strategy etc. with
Above it is associated with device:A () can coat jointing material to all or part of carriage assembly, (b) can be by jointing material
It is integrated in all or part of carriage assembly, (c) jointing material can be coated to all or part of optional covering material
Upper or (d) can be integrated into jointing material in all or part of optional covering material.
Standoff device will be contained using suitable program and import body cavity, for example, blood vessel, gastrointestinal tube chamber, urinary system life
Grow in tube chamber or air flue chamber etc..Then, apply energy to jointing material to activate jointing material and standoff device will be contained
It is attached to bodily cavity tissue.
According to the mechanism for tissue adhesion for being adopted, device attachment can be carried out using different energy sources.Energy source
Can be, for example, thermal source or light source, such as laser instrument or light emitting diode (LED).Infrared and near-infrared laser source includes dioxy
Change carbon (CO2), thulium-holmium-chromium, holmium, thulium and neodymium rear-earth-doped garnet (respectively THC:YAG, Ho:YAG, Tm:YAG and Nd:
) and gallium aluminum arsenide diode (GaAlAs) laser instrument etc. YAG.It can be seen that source includes potassium titanium oxide phosphate (KTP) frequency multiplication Nd:YAG and
Argon laser etc..Other energy sources include radio frequency source (for example, microwave source), radiation source (for example, radiation, x-ray, gamma-radiation etc.)
Or the plasma that local produces.Argon plasma is currently used in the various medical applications including Argon beam blood coagulation device, its
Argon is made to be ionized to form argon plasma and be then used by plasma with the tissue near heat energy is delivered to.
In the present invention, Argon beam can be used as the thermal source of tissue adhesion.
In certain embodiments, the offer energy source energy source in separate unit.In other examples, energy source with
Another device combines.For example, energy source can be combined with conveyer device, such as seal wire or conduit.
In certain embodiments, energy energy source is connected to control unit, the energy that its control is launched from energy source.
Preferably, the amount of energy be enough to activate jointing material without significantly destroying tissue below.In certain embodiments, control
Unit is designed to be used and receives user input (for example, being carried out by physical button, touch screen etc.), so as to allow by medical treatment guarantor
Strong supplier arranges treatment parameter.
In certain embodiments, sensor is not being used (for example, based on surgical experience or based on suitable energy
Output algorithm) in the case of, control energy source.In other examples, carried using sensor with reference to energy source energy source
For the feedback of the amount of the energy with regard to being drawn towards bond site, and this feedback can be used to adjust the output of energy source energy source.
For example, in certain embodiments, sensor is temperature sensor, heat of its detection in bond site.In these embodiments,
Suitable software can be adopted based on the input of temperature sensor to adjust the output of energy source energy source.For example, can with energy
Sensor is provided in the identical device of source or in the device different from the device containing energy source.For example, can be for device
Conveying provides sensor in the medical treatment device (with or without energy source).
Various jointing materials can be used in conjunction with the invention.
In terms of this, laser tissue welding procedure in surgical technic be it is known, from there through by solder (typically
Biopolymer) apply to tissue to come adhesion organization, hereafter, solder is activated using laser and form bonding.It is not intended to be subject to
Theoretical constraint, it has been reported that the mechanism of laser tissue welding seems to include the protein denaturation-renaturation process of heating induction.Ginseng
See, for example, B.Forer etc., Laryngoscope 116:In June, 2006,1002-1006.
In the present invention, solder material is used as jointing material and is bonded to tissue, example will contain standoff device materials
Such as, by solder material and containing standoff device materials (for example, carriage assembly material or optional covering material) and group
Knit, tissue is bonded to so as to standoff device materials will be contained.
As described above, the beneficial energy source for applying heat includes light source (for example, laser instrument etc.), radio frequency source (for example, microwave source etc.)
With plasma source (for example, Argon beam etc.) etc..
Particularly advantageous solder material has relatively low activation temperature and is biological absorbable.For example, solder
Biological absorbable can be realized with the time, (for example, scope is from 4 days to 1 week to 2 weeks to 1 generally between about 4 days and 6 months
The moon was to 2 months to 3 months to 6 months) (that is, the scope between any two aforementioned value), this depends on used solder.
Non-bioresorbable speed can be adjusted with this range by adjusting the chemical property of solder, or than the scope faster or at this
Bio-absorbable is provided after scope.
The concrete solder material being used in conjunction with the invention includes the solder of biogenetic derivation and synthesis solder.The weldering of biogenetic derivation
The example of material includes those based on biopolymer, it may for example comprise the peptide and protein of nano peptide such as albumin, collagen egg
In vain, elastin, fibrin, Fibrinogen, thrombin, thrombinogen protein derivatives and the polysaccharide including shitosan
Deng.In certain embodiments, employ two kinds, three kinds, four kinds or the more kinds of solder materials of those described above.Specifically
Example includes the combination of the combination, collagen protein and shitosan of combination, albumin and the shitosan of albumin and collagen protein, and
The combination of albumin, collagen protein and shitosan, and many other possible combinations.
Other polymer that can add include:The polymer of water solublity or biological absorbable, the water solublity for for example synthesizing
Or the polymer of biological absorbable, such as polylactic acid, polyglycolic acid, polydioxanone, polycaprolactone, tyrosine-based polyester, cheese ammonia
Acidic group Merlon, polyesteramide, polyanhydride, polyhydroxyalkanoate, Polyethylene Glycol, poe, triblock copolymer
(pluronics) poly- (methyl) third that block copolymer such as ethylene glycol and Propylene Glycol, polyamide, polyvinyl alcohol, hydroxyl replace
Olefin(e) acid ester, (methyl) acrylate of Polyethylene Glycol replacement, (methacrylate-b- polyethers) or being total to from these monomer derived
Polymers etc..One or more of these water solublity or biologically absorbable polymer can with the solder of biogenetic derivation, as above
Those mix to change the characteristic of solder material.Used as an instantiation, PLGA can mix white to increase with albumin
The flexibility of albumen solder.
In certain embodiments, strengthened in solder material using at least one energy absorber in solder material
The efficiency of heating surface and/or heat distribution.Energy absorber includes chromophore, for example, light specific dye, such as indocyanine green
(ICG), fluorescein, basic fuchsin and phenol (fen), nano metal such as nanometer gold (for example, gold nanorods, gold nanoshell, Jenner
Rice cage etc.) and SPIONs (SPIO nano particle) etc..Instantiation includes the albumin of ICG doping, fluorescein
The albumin of dyestuff doping and the albumin of nanometer gold doping etc..Metal (for example, gold etc.) or semiconductor nanoparticle (include
Rod, nanoshell and other shapes) solder material can be included in and can be by under the plasma frequency of nano-particle
Excited and heated.For further information, Alexander O.Govorov etc. are see, e.g., " is received with metal
Rice grain produces heat, " Nano Today, volume Two, the 1st phase, 2 months, the 30-38 page 2007.
Photochemical tissue adhesion technique is known in surgical technic.Tissue of these technology utilizations in tight association
The photochemical reaction occurred on surface, tissue surface light-sensitive coloring agent are dyeed the (dyeing for example, being placed in contact with each other
Tissue surface).It is not intended to by theoretical constraint, it is believed that dyestuff absorbs the photon of visible radiation and promotes in the tissue being close to
The formation of the covalent bond between molecule on surface.For example, when dyestuff carries out photoactivation generation reactive species can with it is latent
Electron donor and the receptor such as aminoacid (for example, tryptophan, L-Tyrosine, cysteine etc.) in protein react.
In terms of this, have reported and crosslinking is formed in collagen Types I molecule using photochemical method.Referring to Barbara
P.Chan etc., Journal of Surgical Research, 108,77-84 (2002).
In certain aspects of the invention, tissue surface, example are bonded to so that standoff device will be contained using light-sensitive coloring agent
Such as, by by the light with suitable wavelength apply to (for example, mix with solder material containing standoff device and tissue surface
Or be applied to and contact and be set on the surface of solder material between them containing standoff device and tissue
Light-sensitive coloring agent) light-sensitive coloring agent that is closely associated and solder material (for example, biological solder material, including those described above etc.) and it is real
It is existing, tissue is bonded to so as to standoff device will be contained.Luminous energy source, such as low power laser or light emitting diode (LED)
Can be used for the purpose etc..
The instantiation of light-sensitive coloring agent includes xanthene dye such as rose-bengal, methylene blue and fluorescein, riboflavin dyestuff
(for example, riboflavin-5-phosphoric acid), photopigment dyestuff, photoflavin dyestuff, reactive black 5, thiazine dye, naphthalimide (example
Such as, 1,8-naphthalimide), erythrosine, N- pyridone -2- (1H)-thioketone (N-HTP), ooporphyrin to protoporphyrin IX,
Coproporphyrin, uroporphyrin, Mesoporphyrin, hemoporphyrin and thiophene furan quinoline, chlorophyll such as bacteriochlorophyll A, photofrin, synthesis two porphyrins
Replace with chlorine, the phthalocyanine with or without metal substituent, the chlorine aluminum phthalocyanine with or without different substituent groups, O
Four in tetraphenylporphyrin, 3,1-, (adjacent propionamido- phenyl) porphyrin, verdazulene, purpurin, the stannum of octaethyl alizarinopurpurin and zinc derives
(for example, ooporphyrin is to protoporphyrin IX, excrement for the serial porphine of bacterium of thing, first C.I. Natural Red 8, hydroxy-porphyrin, four (hydroxy phenyl) porphyrin
Porphyrin, uroporphyrin, Mesoporphyrin, hemoporphyrin and thiophene furan quinoline), chlorin, chlorin e 6, the list -1- Radix Asparagis of chlorin e 6
Aminoacyl derivative, two -1- aspartoyl radical derivatives of chlorin e 6, stannum (IV) chlorin e 6, m- tetrahydroxy phenyl
Chlorin, benzoporphyrin derivative, benzoporphyrin mono-acid derivant, the TCNE adduct of benzoporphyrin, benzo porphin
The 2-butyne dicarboxylic ester adduct of quinoline, Diels-Adler adducts, monoacid ring " a " derivant of benzoporphyrin, sulphur
Change aluminum PC, sulfonation AlPc, two sulfonation, the derivant of four sulfonation, the aluminum naphthalene phthalocyanine of sulfonation, with or without metal substituent and
Naphthalene phthalocyanine, chlorophyll with or without different substituent groups, bacteriochlorophyll A, amerantrone, anthracene pyrazoles, amino anthraquinones, fen
It is oxazine dye, phenothiazine derivative, Cha Lekegenpairuili mother's dyestuffs, cation selenium and tellurium pyran derivate, cyclosubstituted
Cation PC, pheophorbide derivatives, naturally occurring porphyrin, hemoporphyrin, the protoporphyrin IX of ALA- inductions, endogenous metabolism
Precursor, 5-ALA, benzo naphtho- porphyrazine, cationic imines salt, tetracycline, moral porphyrin lutecium, texaphyrin,
The stannum cyanine that just purpurin, porphin coffee sage, benzo phenothiazine, eosin, erythrosine, cyanine, M-540, selenium replace, flavin, core
Flavin, proflavine, quinone, anthraquinone, benzoquinone, naphthalimide, Victoria blue, toluidine blue, DIANTHRAQUINONE (for example, Radix Hyperici Monogyni (Herba Hyperici Monogyni)
Element), fullerene, rhodamine and its heliosensitivity derivant.
The advantage non-thermal using light is to make due to heat and risk that caused tissue (cell death) is damaged is less.Use
Light and it is non-thermal come realize device to another advantage for the bonding organized be can reduce or eliminate due to uneven heat distribution and
Caused complication.
In addition, as chromophoric wavelength specific absorbent use make it possible to containing chromophoric region and around
Difference absorption is realized between tissue.One advantage is the selective absorbing for carrying out to radiating by target, accurate without carrying out
Focusing.Further, since the absorption of the increase containing chromophore region, can use relatively low power level, which reduce tissue
Damage.
Include self expandable and balloon expandable device containing standoff device.Carriage assembly containing standoff device can be with
It is metal or polymer, Biostatic or biodegradable.In certain embodiments, carriage assembly is by selected from stainless
The metal of steel, Nitinol, titanium and Elgiloy (Elgiloy) (including the alloy of cobalt, chromium and nickel) etc. is made.
In some other embodiments, holder part by selected from polylactide, PGA, PLG, gather oneself
The biodegradable polymer of lactone and polydioxanone etc. is made.In some further embodiments, holder part is by can
Biodegradable metal, such as ferrum, ferroalloy, magnesium and magnesium alloy etc. are made.
Stent strut can be coated with coating, and the coating is not across the unit between (coating support) pillar.Stent strut
Can be covered by covering material, the covering material is across the unit between (covering support) stent strut.
As it was previously stated, being included bare bracket, medicament elution containing standoff device materials according to what the present invention used
Frame (which can have drug eluting coatings) and the support by covering material partly or completely all standing.Covering material includes non-porous covering
Material (for example, solid film) and there is hole covering material, including perforated film (for example, expanded PTFE or ePTFE) and be based on
The covering of fiber.In terms of this, the various constructing technologies based on fiber can be used for the support covering in the present invention
Come formed and including, such as braided support covering and non-woven support covering (for example it is, knitting, compile twist, it is winding, random
Parcel, spunbond etc.).
Covering material may be selected from various synthesis and natural polymer.For forming having for the covering containing standoff device
Beneficial polymer may be selected from it is following and other:(a) polysiloxanes (that is, silicone), including polydimethylsiloxane (PDMS) etc., (b)
Fluoropolymer, including the homopolymer and copolymer of C2-C8 alkene, one of hydrogen atom above are replaced by fluorine, for example, are gathered
Tetrafluoroethene (PTFE), polyvinylidene fluoride (PVDF), poly- (vinylidene fluoride -co- hexafluoropropene) (PVDF-HFP) etc., (c)
Polyamide, such as nylon etc., (d) polyester, including such as polyethylene terephthalate etc., the poly- ammonia of (e) polyurethane, such as polyether-based
Ester, polycarbonate-based polyurethane and polyolefin-based polyurethane (for example, Polyisobutylene-based polyurethanes) etc., (f) polyolefin homopolymer
And copolymer, including the homopolymer and copolymer of C2-C8 alkene, for example, polyethylene and polypropylene etc., (g) polyoxygenated alkene, bag
The copolymer for including the homopolymer (for example, poly- trioxane, also referred to as polyformaldehyde or acetal) and trioxane of trioxane (for example, three is disliked
The copolymer of alkane and dioxanes) and (h) styrol copolymer, such as alkene-styrol copolymer, including poly- with more than one
The block copolymer of styrene block and more than one polyolefin block, for example, poly- (styrene-b-isobutylene-b-styrene)
(SIBS) or poly- (styrene-b-ethylene/butylene-b- styrene) (SEBS) etc..
Fiber width (for example, the diameter of circular fiber) in fiber base support covering is with very big difference.
In some embodiments, the present invention's can be 1 μm to 500 μm with scope containing standoff device (for example, scope is 1 μm to 2.5
μm to 5 μm to 10 μm to 25 μm to 100 μm to 250 μm to 500 μm) (that is, scope is between any two aforementioned value) and its
The fiber width that he is worth.In certain embodiments, fiber can be provided with surface character, for example, with increase fiber surface area and from
And increase the contact area between fiber and jointing material coating.
Hole bracket covering of the invention can also have the aperture of wide scope.In various embodiments, the present invention
Can be 1 μm to 100 μm with scope containing standoff device (for example, scope is 1 μm to 2.5 μm to 5 μm to 10 μm to 25 μm
To 50 μm to 100 μm) region in (that is, scope is between any two aforementioned value) aperture.
Jointing material can variously be associated containing standoff device.For example, jointing material can be used as at naked
Coating on all or part of of frame component is applied, used as the whole in coating support (for example, bracket for eluting medicament)
Or the coating in a part is applied, or as the support in partly or completely all standing all or part of on coating enter
Row application.Used as another example, jointing material can be by being impregnated into carriage assembly material (particularly polymeric stent material)
Mode in all or part of is mixed, and is mixed in the way of being impregnated in all or part of of support coating material
Close, mixed in the way of being impregnated in all or part of of support covering material or using aforesaid combination.As another
One example, one layer of (for example, a piece of) jointing material can be laminated to carriage assembly material all or part of on, be laminated to
On all or part of of frame coating material, it is laminated on all or part of of support covering material or using aforesaid group
Close.Support covering material can coat, impregnate and/or be laminated viscous before or after support covering material is associated with carriage assembly
Condensation material.
Jointing material may be present in, for example, on the whole length containing standoff device or exist only in along containing
Some points of the length of the device of frame, for example, at the point being associated with the end containing standoff device.This is allowed containing support
The part of device be essentially free of jointing material, which reduce the consumption of jointing material and there are other advantages.
Jointing material can be impregnated into another material and/or is coated to another material using various technologies, it is described
Technology may be selected from, for example dipping technique, spraying technology, spin coating technique, net coating technique, electrostatic technique, wherein by jointing material
Optionally apply to the technology of some containing standoff device rather than other region, for example, can be by using suitable
Bringing device, such as aerosol apparatus, brush, roller, pen or printer (for example, silk-screen printing device, ink-jet printer etc.).
If jointing material is not adhered to support, for example, then the covering material of (optional) or both can be used, is bonded to
A the intermediate layer of () jointing material and (b) support, the covering material of (optional) or both are used as tack coat.In certain embodiments,
Intermediate layer can be transparent for the energy for being applied to jointing material.
As it was previously stated, various embodiments of the present invention are related to containing standoff device, wherein carriage assembly can be, example
Such as, it is metal or polymer, Biostatic or biological absorbable, self expandable or balloon expandable.
In certain embodiments, carriage assembly can be made up of jointing material completely.
In certain embodiments, carriage assembly can be partially or fully coated or be impregnated with jointing material.
In certain embodiments, jointing material can be biological absorbable, for example, except support below after integration
It (is for example, Biostatic in support or optional covering material that anything is not left outside component and/or optional covering material
Or in the case of biological absorbable).As described above, adjustable bioabsorption rate, for example, enter from a few days to a few weeks to some months
OK.
In certain embodiments, carriage assembly element (for example, scaffolding thread, stent strut etc.) can be coated in jointing material
In, this leaves open unit.A specific embodiment is figure 1 illustrates, support 100 is it illustrates, its structural detail is complete
Full coat is covered with jointing material 120, but the carrier unit 110c for wherein staying is open.
In other embodiments, jointing material can cover carrier unit.A specific embodiment is figure 2 illustrates, its
For the schematic diagram of support 100, its carrier unit is coated with jointing material 120.Jointing material can be for example, being only located at structural elements
On outer (outside tube chamber) surface of part 110, it is only located on interior (intraluminal) surface of structural detail 110 or can be entirely around knot
Constitutive element part 110.
In certain embodiments, holder part is coated or impregnated with jointing material.A tool is schematically shown in figure 3
Body embodiment, which illustrates support 100, wherein only applying jointing material 120 to structural detail 110 in the end of support.In Fig. 4
In schematically show another specific embodiment, wherein jointing material 120 is applied to knot along the length compartment of terrain of support 100
Constitutive element part 110.In the embodiment for illustrating in figures 3 and 4, jointing material 120 crosses at least part of carrier unit.Jointing material
120 can be with, for example, is only located on outer (outside tube chamber) surface of structural detail 110, is only located at the interior (tube chamber of structural detail 110
It is interior) on surface or can be entirely around structural detail 110.In other embodiments, structural detail is coated with jointing material, and this stays
The carrier unit of lower opening.
In certain embodiments, there is provided containing standoff device, wherein carriage assembly is partially or completely coated with covering material
Material.Elsewhere, carriage assembly can be metal or polymer, Biostatic or biological absorbable, self expandable or
Balloon expandable.Covering material can be Biostatic or biological absorbable, have hole or non-porous.Covering material can be
Braiding or non-woven fibrous structure.Covering material can completely or partially cover carriage assembly.
Partly or completely the support of all standing can transfer to be partially or fully coated jointing material.For example, partially or completely
The support of covering outside on (outside tube chamber) surface, rather than can be coated with jointing material on interior (in tube chamber) surface.Partially or completely
The support of covering can or be close to the end of support or be coated with jointing material in any other strategic area.Partly or completely
The support of all standing can be coated with jointing material on covering rather than on carriage assembly.
A specific embodiment is schematically shown in fig. 5, wherein the central area of only holder part is coated over and covers
In cover material 130.The end of the support in the uncovered region in covering material 130, jointing material 120 is applied
To structural detail 110.In an illustrated embodiment, jointing material 120 crosses over carrier unit, in this case jointing material
120 may be present in for example, only on outer (outside tube chamber) surface of structural detail 110, (the tube chamber only in the structural detail 110
It is interior) on surface or can be entirely around structural detail 110.In other embodiments, structural detail is coated with jointing material, and this stays
The carrier unit of lower opening.
Another specific embodiment is schematically shown in figure 5b, wherein whole support is coated in covering material 130,
And in the end of support, jointing material 120 is applied to covering material.In certain embodiments, covering material can be by institute
It is made up of transparent material for the adhesion energy of applying, (that is, is being propped up so that coming from and being located in tube chamber relative to covering material
In frame) the adhesion energy of energy source can reach the jointing material being positioned on outer (outside tube chamber) surface of material.If
Intermediate layer (not shown) is set between jointing material 120 and covering material 130, and intermediate materials then also can be by for being applied
It is made up of transparent material for adhesion energy.
In certain embodiments, for example, as shown in FIG. 6, covering material 130 can have various sizes of opening to permit
Perhaps energy passes through covering and activates jointing material 120.Jointing material 120 may span across hole, as illustrated, and in some embodiments
In, can be applied to covering material 130 all or part of.In certain embodiments, structural detail 110 is coated with bonding material
Material, but leave open carrier unit.
In certain embodiments, jointing material is applied to independently of the position containing standoff device, in such case
Under, can be associated with jointing material (see, e.g. Fig. 1-6) in conveying containing standoff device or can not contain in conveying
Jointing material.In these embodiments, jointing material can be applied to tissue, next conveying contains standoff device, or can
Next conveying then applies jointing material containing standoff device.After gatherer and jointing material, using suitable energy
Amount source irradiation unit and jointing material.
The jointing material that can independently apply by solid form, fluid form or combinations thereof application.Pressing solid form
In the case of carrying out independent deposition, jointing material can be adopted, and for example, be mounted to device (for example, the ball for being suitable to radial dilatation
Capsule) on paster form or the form of thin film or band, which can pass through extension fixture (for example, by balloon inflation) and extruded tube
Cavity wall.In the case where independent deposition is carried out by fluid form, jointing material can be adopted, for example, the shape of liquid, paste or gel
Formula (organic or waterborne liquid for example, including more solid material and/or light-sensitive coloring agent, paste or gel), which is using closing
Suitable device, such as conduit are deposited.For example, before arrangement is containing standoff device, material will can be bonded through conduit
Material applies to body cavity or after Jing conduits are arranged, and jointing material can be deposited to containing on standoff device.Then, Jing
Cross suitable energy source irradiation jointing material and containing standoff device, for example, conduit or another work are deposited using being integrated into
Energy source in tool is carried out.
In certain embodiments, in the case where not being implanted into containing standoff device, jointing material can be applied to body cavity.
In the case of being deposited by solid form, jointing material can be adopted, and for example, be mounted to and be suitable on the device of radial dilatation
Paster form or the form of thin film or band.Once extruding wall of the lumen, then can will bond material by being exposed to energy
Material is soldered to the wall.For example, this can be used to repairing and/or being sealed in the breach in tube chamber.In other embodiments, using fluid
The jointing material of form can be used to repairing and/or being sealed in the breach in tube chamber.
As it was previously stated, various energy sources can be adopted in the present invention.In certain embodiments, with reference to the independent dress of its own
Offer energy source is provided, but in other embodiments, energy source can be integrated in conveyer device.In various embodiments, energy
Source is suitable to radially guide energy from the side of device.In some cases, energy source be it is rotatable (for example, manually
Or mechanically carry out), this allows to guide energy in the way of wholecircle (that is, 360 ° irradiations).For example, also can be by from the whole of device
Guide energy (for example, via multiple LED, multiple optical fiber etc.) to realize wholecircle irradiation around individual circumference.In some embodiments
In, by transparent material, for example, transparent hollow conduit axle or transparent sacculus and other possible devices are from energy source
Guide energy.
In the embodiment that the self-contained unit with reference to its own provides energy source, energy source can be being for example integrated into seal wire
In upper or single track conduit, or for example, energy source can also pass through the inner chamber insertion in delivery conduit.In Fig. 10 shown one
In individual embodiment, light-emitting device 340 can be provided with multiple light-emitting component 340e, for example, multiple LED or fibre-optic terminuss, which is from device
Outwards radiated.
One example of the one embodiment being integrated into as energy source in conveyer device, energy source can be integrated into and lead
In silk 345, as shown in Figure 11, for example, realized by making seal wire be provided with emitting optical fiber core 345e.The light for coming from the core can
Radially disperseing from the point that light is sent using the core of suitable optical element.In some other embodiments, energy source quilt
It is integrated in delivery conduit.For example, delivery conduit can be provided with multiple LED or fibre-optic terminuss, and which outwards carries out spoke from delivery conduit
Penetrate.In certain embodiments, energy source is provided with reference to foley's tube, energy source 360e can be mounted to sacculus in this case
The distally of the sacculus 365 of conduit 360, as shown in Figure 12.Energy source may be alternatively located at the nearside of sacculus or be located in sacculus.Such as
Fruit be located at sacculus in, sacculus then by for irradiation energy for be made up of transparent material.Energy source is provided with sacculus
Advantage is that sacculus helps to maintain energy source positioned at the center of body cavity.Certainly, the mechanism in addition to sacculus, such as conveying shield
Set or support can be used to make energy source feel relieved.
One embodiment of program for transfer gantry of the invention will be described with reference to Fig. 7 A-7C now.Initially,
Seal wire 310 is positioned in body cavity 200, as shown in fig. 7.Then, the transfer gantry on seal wire 310.For example, can use
In support conveying technology, known conveyer device carrys out transfer gantry, and for example, its medium-height trestle is located at outer catheter sheath 330 and interior leads
The device of transfer position is transported between pipe component 320 and after sheath 330 is retracted, be this generates as shown in fig. 7b
The self expandable of support.However, different from program known to other, the support in the present embodiment is being propped up for wherein support element 110
The end coated of frame has the support of jointing material 120.In an illustrated embodiment, after transfer gantry, delivery conduit is fetched,
And device 340 of the importing with energy emitting element 340e on seal wire 310, this allows activation jointing material 120 and will prop up
Frame is fixed to the tissue of body cavity 200.In other embodiments, energy source can be included in delivery conduit.
Another embodiment of program for transfer gantry of the invention will be described with reference to Fig. 8 A-8C now.
In this embodiment, the first conduit 350 with the first sacculus 355 is located in body cavity 200, as shown in fig. 8 a, its stop
Can be such as blood vessel body cavity 200 in flowing.Then, support 100 is delivered to positioned on the first conduit 350
Position on second conduit 360 of propulsion, as shown in FIG. 8B.In an illustrated embodiment, the whole length of support 100
It is provided with jointing material.As seen in Fig. 8 C, the second conduit 360 has the second sacculus 365, and which makes support in inflation
100 expand in body cavity 200.After stent-expansion, the energy source in the sacculus 365 of the second conduit 360 can be used to activate
Jointing material in support 100, this allows support to be fixed to the tissue of body cavity 200.In other embodiments, Jing is individually filled
Put importing energy source.
Another embodiment of program for transfer gantry of the invention will be described with reference to Fig. 9 now.At this
In embodiment, will be with support using suitable conveying technology (for example, Jing has the conduit of recoverable sheath, foley's tube etc.)
The self expandable or balloon expandable stent of element 110 and support covering 130 is delivered to body cavity 200.Next, using conduit
Jointing material is delivered to support by 370.For example, as shown in FIG. 9, can be using liquid form from delivery conduit 370
More than one tube chamber 370l carries out the conveying of jointing material 120.After jointing material 120 is applied, the suitable energy source of ECDC
370e is illuminated to support and tissue, supplies energy source 370e in this embodiment on conduit 370, viscous so as to activate
Condensation material 120 is so that support to be bonded to the tissue of body cavity 200.In other embodiments, the single devices of Jing insert energy source.
In certain embodiments, it is of the invention to may include various extra reagents, including therapeutic agent containing standoff device
With preparation and other possible reagents.This reagent can be included in, for example, carriage assembly material whole or one
It is point upper or be incorporated in in coating therein, on all or part of of jointing material or it is incorporated in in coating therein
And/or as on all or part of of optional covering material or being incorporated in coating therein.
" therapeutic agent ", " medicine ", " bioactivator ", " medicament ", " pharmaceutically active agents " and other relational languages are herein
In can be with used interchangeably.Therapeutic agent includes anti-restenosis, resisting hypertension and anti-granulation tissue agent.Therapeutic agent can individually or combine make
With.
Also include preparation containing the extra reagent that standoff device is used with reference to of the invention, which includes that (a) combines x
The contrast agent that actinoscopy X is used, including metal, slaine and oxide (particularly bismuth salt and oxide) and iodinated compounds
(that is, the ultrasonic energy for reflecting is caused to increase Deng, (b) contrast agent used with reference to ultra sonic imaging, including organic and inorganic echo granule
Plus granule) or organic and inorganic echo transparent grain (that is, cause reflect ultrasonic energy reduce granule), and (c) knot
The contrast agent that nuclear magnetic resonance (MRI) is used is closed, including the contrast agent containing the element with relatively large magnetic moment, such as God
(III), MN (II), Fe (III) and the compound containing which (including chelate), as chelated with diethylene-triamine pentaacetic acid
Gadolinium ion.
In various embodiments, containing standoff device can containing less than 1wt% to 50wt% or more more than one
Aforementioned additional agents.
In another aspect of the present invention, there is provided can be used for the medical external member in the operation containing standoff device.
Medical external member may include to can be used for whole or its subset in all component for perform the operation.For example, medical external member may include
Any two kinds, three kinds, more than four kinds of combination in any in following items:A (), containing standoff device, which does not have or has phase
The jointing material of association, (b) jointing material, for example, using fluid form or solid form, (c) more than one medical treatment device
(for example, seal wire, stent conveying device and/or the device for applying jointing material), (d) energy source is (for example, in independent list
It is associated in unit or with surgical instrumenties), (e) suitable packaging material, and the printing material of (f) with more than one following items
Material:(1) storage information and (2) are implanted into instruction containing standoff device in subject with regard to how.
Although specifically describing and describing various embodiments herein, it is to be understood that without departing from the present invention
Spirit and preset range on the premise of, the present invention modification and modification covered and fallen in appended right by above-mentioned religious doctrine
Among the scope of requirement.
Claims (15)
1. a kind of medical treatment device, which includes (a) carriage assembly, (b) optional covering material, and (c) and the carriage assembly,
The associated jointing material of described optional covering material or both;Wherein described medical treatment device is configured to when the bonding material
Material is bonded to tissue when being exposed to energy source.
2. medical treatment device according to claim 1, wherein the jointing material includes tissue solders material, or wherein institute
Stating jointing material includes tissue solders and photosensitizing dye, or wherein described jointing material includes tissue solders and energy absorber.
3. the medical treatment device according to any one of claim 1-2, wherein the jointing material is included selected from shitosan, white
Albumen, collagen protein, elastin, Fibrinogen, nano peptide, aforesaid derivant and aforesaid two or more combination
Tissue solders.
4. the medical treatment device according to any one of claim 1-3, wherein the jointing material includes tissue solders and sense
Photoinitiator dye, the photosensitizing dye is selected from rose-bengal dyestuff, methylene blue dye, fluorescein(e) dye, indocyanine green, alkaline product
Red, phenol, xanthane dyestuff, riboflavin dyestuff, photopigment dyestuff, flavin, photoflavin dyestuff, reactive black 5 dye and aforementioned two
Plant the combination of the above.
5. the medical treatment device according to any one of claim 1-3, wherein the jointing material includes tissue solders and energy
Amount absorbent, the energy absorber are selected from chromophore, SPIO nano particle (SPIONs), gold nanorods, gold
Nanoshell, gold nanometer cage and aforementioned two or more combination.
6. medical treatment device according to claim 1, wherein the jointing material includes tissue solders and synthetic polymer, institute
Synthetic polymer is stated selected from polylactic acid, polyglycolic acid, poly- (lactic-co-glycolic acid), polydioxanone, polycaprolactone and front
State two or more combinations.
7. the medical treatment device according to any one of claim 1-6, wherein the jointing material (a) is by the support
The coating of the jointing material at least a portion of component, the optional covering material or both, (b) by by institute
State jointing material to be integrated at least a portion of the carriage assembly, the optional covering material or both, or (c) passes through
The combination of (a) and (b) and be associated with the medical treatment device.
8. medical treatment device according to claim 7, wherein the end of the jointing material and the medical treatment device, rather than
It is associated with the center of the medical treatment device, or a series of band wherein as the length along the medical treatment device or island is carrying
For the jointing material.
9. the medical treatment device according to any one of claim 1-8, wherein the medical treatment device includes the covering material.
10. medical treatment device according to claim 9, wherein the covering material only covers of the carriage assembly
Point, and wherein jointing material is related to the carriage assembly in the region that the carriage assembly is not covered by the covering material
Connection.
11. medical treatment devices according to claim 9 or 10, wherein the end of the carriage assembly is not by the covering material
Cover and/or wherein described covering material be provided with multiple openings, the plurality of opening provide the carriage assembly not by
The region that the covering material is covered.
12. medical treatment devices according to any one of claim 9-11, wherein the covering material is for the energy foot
It is transparently enough, can be activated relative to the covering material using intraluminal energy source is located at relative to the covering material
And it is located at the jointing material outside tube chamber.
13. medical treatment devices according to claim 12, which also includes being arranged on the jointing material and the covering material
Intermediate layer between material, wherein the intermediate layer material for the energy be enough to it is transparent, with can be using relative in described
Interlayer material and be located at the activation of intraluminal energy source and be located at the jointing material outside tube chamber relative to the intermediate layer material.
A kind of 14. external members, which includes any two or more combination in following items:A () medical treatment device, which includes support group
Part, optional covering and the optional jointing material being associated with the carriage assembly, the optional covering or both,
(b) using solid form or the jointing material of fluid form, (c) surgical device, its with or without associated energy source,
The surgical device is configured to receive the medical treatment device and be placed in subject, (d) seal wire, and which has or does not have
There are associated energy source, or (e) separate energy source.
15. external members according to claim 14, wherein the medical treatment device includes that what is be associated with the carriage assembly is glued
Condensation material.
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US201462018262P | 2014-06-27 | 2014-06-27 | |
US62/018,262 | 2014-06-27 | ||
PCT/US2015/038246 WO2015200906A1 (en) | 2014-06-27 | 2015-06-29 | Compositions, devices, kits and methods for attaching stent-containing medical devices to tissue |
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CN106572914A true CN106572914A (en) | 2017-04-19 |
CN106572914B CN106572914B (en) | 2020-09-11 |
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CN201580035084.5A Active CN106572914B (en) | 2014-06-27 | 2015-06-29 | Compositions, devices, kits and methods for attaching a medical device comprising a stent to tissue |
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US (3) | US10610386B2 (en) |
EP (2) | EP4268860A3 (en) |
JP (4) | JP2017519542A (en) |
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WO (1) | WO2015200906A1 (en) |
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JP6971274B2 (en) | 2021-11-24 |
EP3160525A1 (en) | 2017-05-03 |
US20220354672A1 (en) | 2022-11-10 |
WO2015200906A1 (en) | 2015-12-30 |
EP3160525B1 (en) | 2023-08-09 |
JP2023166524A (en) | 2023-11-21 |
US10610386B2 (en) | 2020-04-07 |
US11413170B2 (en) | 2022-08-16 |
JP2017519542A (en) | 2017-07-20 |
US20200206001A1 (en) | 2020-07-02 |
EP4268860A2 (en) | 2023-11-01 |
CN106572914B (en) | 2020-09-11 |
EP4268860A3 (en) | 2024-01-17 |
JP2022020729A (en) | 2022-02-01 |
JP2019195621A (en) | 2019-11-14 |
US20150374516A1 (en) | 2015-12-31 |
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