CA2188185A1 - Slow-release matrix pellets and the production thereof - Google Patents

Slow-release matrix pellets and the production thereof

Info

Publication number
CA2188185A1
CA2188185A1 CA002188185A CA2188185A CA2188185A1 CA 2188185 A1 CA2188185 A1 CA 2188185A1 CA 002188185 A CA002188185 A CA 002188185A CA 2188185 A CA2188185 A CA 2188185A CA 2188185 A1 CA2188185 A1 CA 2188185A1
Authority
CA
Canada
Prior art keywords
release matrix
slow
matrix pellets
production
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002188185A
Other languages
French (fr)
Other versions
CA2188185C (en
Inventor
Sven Grabowski
Joerg Rosenberg
Axel Sanner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2188185A1 publication Critical patent/CA2188185A1/en
Application granted granted Critical
Publication of CA2188185C publication Critical patent/CA2188185C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

Disclosed are sustained-release matrix pellets of spherical to lenticular shape and uniform maximum diameter in the range of 0-5 to 4 mm, consisting of a) 0.1 to 87 wt % of at least one biologically active compound, b) 5 to 50 wt % of at least one water-insoluble polymer, c) 5-45 wt % of at least one lipophilic component as plasticizer for the b) polymer, d) 3 to 40 wt % of a natural or semisynthetic gelling agent, e) 0 to 50 wt% of one or more common formulation auxiliaries.
CA002188185A 1994-04-18 1995-04-05 Slow-release matrix pellets and the production thereof Expired - Lifetime CA2188185C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4413350.2 1994-04-18
DE4413350A DE4413350A1 (en) 1994-04-18 1994-04-18 Retard matrix pellets and process for their production
PCT/EP1995/001236 WO1995028147A1 (en) 1994-04-18 1995-04-05 Sustained-release matrix pellets and method for preparing them

Publications (2)

Publication Number Publication Date
CA2188185A1 true CA2188185A1 (en) 1995-10-26
CA2188185C CA2188185C (en) 2005-06-07

Family

ID=6515707

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002188185A Expired - Lifetime CA2188185C (en) 1994-04-18 1995-04-05 Slow-release matrix pellets and the production thereof

Country Status (23)

Country Link
US (1) US6290990B1 (en)
EP (1) EP0756480B1 (en)
JP (1) JP4099225B2 (en)
KR (1) KR100371885B1 (en)
CN (1) CN1131024C (en)
AT (1) ATE204747T1 (en)
AU (1) AU2256495A (en)
BR (1) BR9507328A (en)
CA (1) CA2188185C (en)
CZ (1) CZ301396A3 (en)
DE (2) DE4413350A1 (en)
DK (1) DK0756480T3 (en)
ES (1) ES2162635T3 (en)
FI (1) FI964175A (en)
HU (1) HU221981B1 (en)
IL (1) IL113316A (en)
MX (1) MXPA96004911A (en)
NO (1) NO313735B1 (en)
NZ (1) NZ284064A (en)
PL (1) PL317936A1 (en)
PT (1) PT756480E (en)
RU (1) RU2155031C2 (en)
WO (1) WO1995028147A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387401B2 (en) 1995-08-25 2002-05-14 Basf Aktiengesellschaft Use of lipids as adjuvents in the production of solid medicinal forms by the melt extrusion process
WO2002060384A2 (en) 2001-01-30 2002-08-08 Smithkline Beecham Plc. Pharmaceutical formulation
WO2005009380A2 (en) 2003-07-21 2005-02-03 Smith Kline Beecham P.L.C. Pharmaceutical formulations
WO2009087483A2 (en) 2007-11-08 2009-07-16 Glaxo Group Limited Pharmaceutical formulations

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US5965161A (en) † 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE19539362A1 (en) * 1995-10-23 1997-04-24 Basf Ag Process for the production of solid dosage forms
DE19539360A1 (en) * 1995-10-23 1997-04-24 Basf Ag Process for the production of solid dosage forms
FR2748209B1 (en) * 1996-05-06 1998-06-05 Adir PHARMACEUTICAL COMPOSITION BASED ON STABILIZED LIPOPHILIC MATRICES FOR THE CONTROLLED RELEASE OF ACTIVE INGREDIENTS
DE19637082A1 (en) 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Rapidly disintegrating pellets
US8828432B2 (en) * 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
FR2761605B1 (en) * 1997-04-07 2001-02-23 Prographarm Lab MULTIPARTICULAR PHARMACEUTICAL FORM, ITS CONSTITUENT PARTICLES, METHOD AND PLANT FOR THEIR MANUFACTURE
ATE438305T1 (en) * 1998-03-23 2009-08-15 Gen Mills Inc ENCAPSULATION OF COMPONENTS IN EDIBLE PRODUCTS
DE19842753A1 (en) 1998-09-18 2000-03-23 Bayer Ag Multiple-unit retard oral dosage formulation having controlled release independent of agitation and food effect, containing particles of combination of drug and hydroxypropyl cellulose
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DE10045904B4 (en) * 1999-10-01 2007-07-12 Degussa Gmbh alpha-lipoic acid (derivatives) containing sustained release form
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US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
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US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
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US7842308B2 (en) 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387401B2 (en) 1995-08-25 2002-05-14 Basf Aktiengesellschaft Use of lipids as adjuvents in the production of solid medicinal forms by the melt extrusion process
WO2002060384A2 (en) 2001-01-30 2002-08-08 Smithkline Beecham Plc. Pharmaceutical formulation
WO2002060385A2 (en) 2001-01-30 2002-08-08 Smithkline Beecham Plc. Pharmaceutical formulation
EP2366384A2 (en) 2001-01-30 2011-09-21 Pfizer Inc. Pharmaceutical formulation
EP2366383A2 (en) 2001-01-30 2011-09-21 Pfizer Inc. Pharmaceutical formulation
EP2366382A2 (en) 2001-01-30 2011-09-21 Pfizer Inc. Pharmaceutical formulation
WO2005009380A2 (en) 2003-07-21 2005-02-03 Smith Kline Beecham P.L.C. Pharmaceutical formulations
WO2009087483A2 (en) 2007-11-08 2009-07-16 Glaxo Group Limited Pharmaceutical formulations

Also Published As

Publication number Publication date
US6290990B1 (en) 2001-09-18
JP4099225B2 (en) 2008-06-11
RU2155031C2 (en) 2000-08-27
KR970702028A (en) 1997-05-13
NO964410L (en) 1996-12-17
NZ284064A (en) 1998-03-25
FI964175A0 (en) 1996-10-17
WO1995028147A1 (en) 1995-10-26
DK0756480T3 (en) 2001-10-08
PT756480E (en) 2002-02-28
DE4413350A1 (en) 1995-10-19
PL317936A1 (en) 1997-04-28
FI964175A (en) 1996-12-16
ES2162635T3 (en) 2002-01-01
IL113316A (en) 1999-12-31
MXPA96004911A (en) 2004-08-19
EP0756480B1 (en) 2001-08-29
CA2188185C (en) 2005-06-07
IL113316A0 (en) 1995-07-31
HU9602878D0 (en) 1996-12-30
BR9507328A (en) 1997-09-30
HUT75161A (en) 1997-04-28
NO313735B1 (en) 2002-11-25
KR100371885B1 (en) 2003-04-10
CN1147764A (en) 1997-04-16
EP0756480A1 (en) 1997-02-05
HU221981B1 (en) 2003-03-28
AU2256495A (en) 1995-11-10
NO964410D0 (en) 1996-10-17
ATE204747T1 (en) 2001-09-15
DE59509563D1 (en) 2001-10-04
CN1131024C (en) 2003-12-17
JPH09511992A (en) 1997-12-02
CZ301396A3 (en) 1997-03-12

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